MPD: List measures where strain BTBR T<+> Itpr3<tf>/J is an outlier

List measures where BTBR T⁺ Itpr3^tf/J is an outlier

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Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Ackert1:6	Ackert1	body size and weight	(none)	body weight [g] BW 25006 6mo 12mo 20mo	inbred	32	both		N=7	2008

Ackert1:41	Ackert1	DXA	(none)	total tissue mass, head excluded [g] TTM 25041 6mo 12mo 20mo	inbred	32	both		N=7	2008

Ackert1:46	Ackert1	DXA	(none)	weight of lean tissue mass, head excluded [g] LTM 25046 6mo 12mo 20mo	inbred	32	both		N=7	2008

Berndt2:1	Berndt2	plethysmography	methacholine	minute ventilation [mL/min] min_vent 35101 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:8	Berndt2	plethysmography	methacholine	breath frequency [n/min] breath_freq 35108 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:14	Berndt2	plethysmography	methacholine	inspiratory phase [s] inspiratory 35114 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:21	Berndt2	plethysmography	methacholine	expiratory phase [s] expiratory 35121 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:28	Berndt2	plethysmography	methacholine	respiratory cycle [s] tot_respi 35128 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:34	Berndt2	plethysmography	methacholine	duty cycle [ratio] duty_cycle 35134 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:41	Berndt2	plethysmography	methacholine	inspiratory flow rate [mL/kg/s] insp_flow 35141 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:48	Berndt2	plethysmography	methacholine	expiratory flow rate [mL/kg/s] exp_flow 35148 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:54	Berndt2	plethysmography	methacholine	respiratory flow rate [mL/kg/s] resp_flow 35154 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:61	Berndt2	plethysmography	methacholine	enhanced pause penh 35161 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:68	Berndt2	plethysmography	methacholine	tidal volume [mL] tidal_vol 35168 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt4:2	Berndt4	histopathology	(none)	lung adenoma severity score [score] adenoma_score 48302	inbred	28	both	90wks	N=10	2011

Bolivar4:1	Bolivar4	open field test	(none)	distance traveled on day 1, 15 min test [cm] dist_5min_d1 64701 first 5 min second 5 min third 5 min	inbred	14	m	8-12wks	N=18	2009

CGDpheno1:2	CGDpheno1	complete blood count	(none)	red blood cell count (RBC; per volume x 10⁶) [n/µL] RBC 31802	inbred w/CC8	72	both	11wks	N=7	2009

CGDpheno1:25	CGDpheno1	complete blood count	(none)	hematocrit (HCT) [%] HCT 31825	inbred w/CC8	72	both	11wks	N=7	2009

CGDpheno1:61	CGDpheno1	metabolic panel	(none)	dissolved-ionized carbon dioxide (CO₂) [mmol/L] carbon_dioxide 31861	inbred w/CC8	72	both	12wks	N=8	2009

Cowell1:1	Cowell1	hormone quantification	Staphylococcus aureus	fold-change in serum IL-6 levels 24h post-infection compared to controls [ratio] IL6 49001	inbred	13	f	8wks	N=3	2012

Crabbe1:2	Crabbe1	body weight	(none)	body weight [g] bw 15402	inbred	8	both	8-16wks	N=34	2003

Crabbe3:1	Crabbe3	body weight	(none)	body weight on test day (local parameter) [g] bw 15801	inbred	9	both	9-17wks	N=17	2003

Crabbe3:31	Crabbe3	rotarod	(none)	accelerating rotarod (ARR1) acquisition trial average of last 3 trials minus average of first 3 trials (20 rpm/min) [s] ARR1_improvement 15831	inbred	8	both	9-17wks	N=6	2003

Crabbe3:40	Crabbe3	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1) [s] ARR1_20rpm 15840 baseline ethanol difference	inbred	8	both	9-17wks	N=6	2003

Crabbe3:45	Crabbe3	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 2 30 rpm/min (ARR1) [s] ARR1_30rpm 15845 baseline ethanol difference	inbred	8	both	9-17wks	N=6	2003

Crabbe4:6	Crabbe4	grip strength	ethanol	grip strength test: peak force applied [g] grip 19106 baseline 30min after ethanol	inbred	21	both	7-12wks	N=6	2003

Donahue1:2	Donahue1	DXA	(none)	whole body bone mineral content (BMC) [g] body_BMC 11508	inbred w/CC7	30	both	15-16wks	N=10	2002

Donahue1:18	Donahue1	hormone quantification	(none)	insulin-like growth factor 1 (adjusted serum IGF-1) [ng/mL] IGF_1 11532	inbred w/CC7	30	both	15-16wks	N=9	2002

Evsikova1:1	Evsikova1	body weight	(none)	body weight [g] bw 24701 test start test end change	inbred	14	both	26wks	N=7	2009

Evsikova1:26	Evsikova1	monitoring system	(none)	rearing activity (beam break triplets during 24h) [n] vert 24726 daily light dark	inbred	14	both	26wks	N=7	2009

Harrill2:41	Harrill2	organ weights	DB289	kidney (left) weight [g] Lt_kidney 44141 control DB289	inbred	34	f	6-8wks	N=5	2012

Harrill2:44	Harrill2	organ weights	DB289	kidney (right) weight [g] Rt_kidney 44144 control DB289	inbred	34	f	6-8wks	N=5	2012

Harrill2:48	Harrill2	organ weights	DB289	kidney (both) weight [g] both_kidney 44148 control DB289	inbred	34	f	6-8wks	N=5	2012

HMDPpheno1:1	HMDPpheno1	DXA	(none)	whole body bone mineral density (BMD; skull, lumbar spine, left femur excluded) [g/cm²] BMD_body 44601	HMDP w/par	96	m	16wks	N=9	2011

HMDPpheno1:3	HMDPpheno1	DXA	(none)	bone mineral density (BMD) of lumbar spine [g/cm²] BMD_spine 44603	HMDP w/par	96	m	16wks	N=9	2011

Justice2:4	Justice2	complete blood count	(none)	white blood cell count (WBC; per volume x 10³) [n/µL] WBC 13204	inbred	16	both	12-16wks	N=12	2002

Kumar3:21	Kumar3	open field test	(none)	time spent grooming first 55 min [s] GrTime55m 112929	inbred w/CC8	62	both	8-14wks	N=20	2021

Kumar3:28	Kumar3	open field test	(none)	duration of grooming events first 20 min (s per event) [s/n] GrBoutLength20m 112936	inbred w/CC8	62	both	8-14wks	N=19	2021

Kumar3:29	Kumar3	open field test	(none)	duration of grooming events first 55 min (s per event) [s/n] GrBoutLength55m 112937	inbred w/CC8	62	both	8-14wks	N=20	2021

Kumar4:14	Kumar4	gait analysis	(none)	lateral displacement of nose keypoint, mean nose_lateral_displacement_mean 114444	inbred w/CC8	62	both	10-20wks	N=19	2021

Kumar4:15	Kumar4	gait analysis	(none)	lateral displacement of nose keypoint, median nose_lateral_displacement_median 114445	inbred w/CC8	62	both	10-20wks	N=19	2021

Maurer1:9	Maurer1	tail cuff	atenolol, isoproterenol	systolic blood pressure [mmHg] BP 33209 control atenolol 10mg isoprot 1mg isoprot 10mg	inbred	23	m	7-13wks	N=10	2009

Maurer1:17	Maurer1	ECG	atenolol, isoproterenol	amplitude of Q-wave [mV] Q_amp 33217 control atenolol 10mg isoprot 1mg isoprot 10mg	inbred	23	m	7-13wks	N=9	2009

Maurer1:21	Maurer1	ECG	atenolol, isoproterenol	amplitude of R-wave [mV] R_amp 33221 control atenolol 10mg isoprot 1mg isoprot 10mg	inbred	23	m	7-13wks	N=9	2009

Maurer1:29	Maurer1	ECG	atenolol, isoproterenol	duration P-wave [ms] P_dur 33229 control atenolol 10mg isoprot 1mg isoprot 10mg	inbred	23	m	7-13wks	N=10	2009

Maurer1:41	Maurer1	ECG	atenolol, isoproterenol	interval QRS [ms] QRS 33241 control atenolol 10mg isoprot 1mg isoprot 10mg	inbred	23	m	7-13wks	N=10	2009

Maurer1:45	Maurer1	ECG	atenolol, isoproterenol	interval QT [ms] QT 33245 control atenolol 10mg isoprot 1mg isoprot 10mg	inbred	23	m	7-13wks	N=10	2009

Maurer1:65	Maurer1	body weight	(none)	body weight at start of testing, all cohorts combined [g] bw_start 33265	inbred	23	m	7-13wks	N=40	2009

Maurer1:70	Maurer1	organ weights	atenolol, isoproterenol	heart weight [mg] heart_wt 33270 control atenolol 10mg isoprot 1mg isoprot 10mg	inbred	23	m	7-13wks	N=11	2009

Maurer1:78	Maurer1	organ weights	atenolol, isoproterenol	atria weight [mg] atria_wt 33278 control atenolol 10mg isoprot 1mg isoprot 10mg	inbred	23	m	7-13wks	N=10	2009

Maurer1:86	Maurer1	organ weights	atenolol, isoproterenol	ventricle (both) weight [mg] ventr_wt 33286 control atenolol 10mg isoprot 1mg isoprot 10mg	inbred	23	m	7-13wks	N=11	2009

Maurer1:99	Maurer1	colony observation	(none)	age at testing (local parameter) [wks] age 33299	inbred	23	m		N=42	2009

Metten1:1	Metten1	open field test	ethanol	line crossings, 2.75 g/kg i.p. [n] line_doseA 16501 pre-injection 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten2:1	Metten2	body weight	(none)	body weight [g] bw 19501 start fold change after testing	inbred	15	m	8-15wks	N=20	2005

Paigen1:14	Paigen1	histopathology	high-fat diet	gallbladder, fused liquid crystals (score: 0-4) [score] fusedLC 2914	inbred	43	both	15-19wks	N=8	2000

Peters1:15	Peters1	complete blood count	(none)	large unstained cell differential (percent of total WBC) [%] LUC 6215	inbred w/CC7	43	both	10wks	N=12	2001

Peters4:5	Peters4	complete blood count	(none)	red blood cell count (RBC; per volume x 10⁶) [n/µL] RBC 24305 6mo 12mo 18mo 24mo	inbred	30	both		N=7	2007

Peters4:29	Peters4	complete blood count	(none)	large unstained cells count (LUC; units per volume x 10³) [n/µL] LUC 24329 6mo 12mo 18mo 24mo	inbred	30	both		N=7	2007

Peters4:53	Peters4	complete blood count	(none)	large unstained cells differential (LUC; percentage of total WBC) [%] pctLUC 24353 6mo 12mo 18mo 24mo	inbred	30	both		N=7	2007

Peters4:57	Peters4	complete blood count	(none)	hematocrit (HCT) [%] pctHCT 24357 6mo 12mo 18mo 24mo	inbred	30	both		N=7	2007

Peters4:61	Peters4	complete blood count	(none)	hemoglobin (HGB) [g/dL] HGB 24361 6mo 12mo 18mo 24mo	inbred	30	both		N=7	2007

Peters4:77	Peters4	complete blood count	(none)	reticulocyte count (Retic) [n/L] Retic 24377 6mo 12mo 18mo 24mo	inbred	30	both		N=7	2007

Peters4:81	Peters4	complete blood count	(none)	reticulocyte differential [%] pctRetic 24381 6mo 12mo 18mo 24mo	inbred	30	both		N=7	2007

Peters4:93	Peters4	complete blood count	(none)	platelet count (PLT; units per volume x 10³) [n/µL] Plt 24393 6mo 12mo 18mo 24mo	inbred	30	both		N=7	2007

Rusyn2:67	Rusyn2	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] DCA_tce 36167 time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn5:5	Rusyn5	alcohol quantification	high-fat diet and ethanol	blood alcohol concentration (BAC) [mg/dL] BAC 43005 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:33	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver S-adenosylhomocysteine (SAH) [nmol/mg] liver_SAH 43033 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn6:14	Rusyn6	histopathology	trichloroethylene	BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group [%] BrdU_liver_tce 51214	inbred	7	m	6-7wks	N=3	2014

Schwartz2:2	Schwartz2	bronchoalveolar lavage assessment	ovalbumin	alveolar eosinophils (percentage of total lavage cells), 24h post-challenge [%] pctEOS24 9802 24h post: control OVA-sensitized	inbred	8	m	6-8wks	N=5	2001

Schwartz2:42	Schwartz2	bronchoalveolar lavage assessment	ovalbumin	alveolar neutrophils (percentage of total lavage cells), 24h post-challenge [%] pctNEUT24 9842 24h post: control OVA-sensitized	inbred	8	m	6-8wks	N=5	2001

Seburn1:4	Seburn1	colony observation	(none)	animal age at test (local parameter) [d] age 9204	inbred	16	both		N=8	2001

Seburn2:1	Seburn2	grip strength	(none)	grip strength, peak tension over 3 trials [g] grip_strength 24801 6mo 12mo 18mo 24mo	inbred	32	both		N=8	2008

Tordoff3:8	Tordoff3	bottle choice test	(none)	preference for CaCl2 (calcium chloride) solutions [%] CaCl2_pref 10308 concentration (mM): 7.5 25 75	inbred w/CC7	40	both	9-11wks	N=10	2002

Tordoff3:11	Tordoff3	bottle choice test	(none)	preference for CaLa (calcium lactate) solutions [%] CaLa_pref 10311 concentration (mM): 7.5 25 75	inbred w/CC7	40	both	10-12wks	N=10	2002

Tordoff3:21	Tordoff3	metabolic panel	(none)	blood ionized calcium [mg/dL] ionized_Ca 10321	inbred w/CC7	40	both	13-15wks	N=10	2002

Vinyard1:1	Vinyard1	bone dimensions	(none)	distance between upper and lower incisor tips at maximum passive jaw opening (maximum gape) [mm] max_gape 30401	inbred	21	both	9-12wks	N=10	2009

Vinyard1:3	Vinyard1	bone dimensions	(none)	distance from the incisor alveolus to the caudal surface of the mandibular condyle (jaw length) [mm] jaw_length 30403	inbred	21	both	9-12wks	N=10	2009

Vinyard1:8	Vinyard1	body weight	(none)	body weight [g] bw 30408	inbred	21	both	9-12wks	N=10	2009

Wahlsten1:3	Wahlsten1	body weight	(none)	body weight, end of testing (local parameter) [g] bw 10803	inbred	21	both	12wks	N=10	2003

Wahlsten1:6	Wahlsten1	histopathology	(none)	length of corpus callosum at mid-sagittal plane [mm] cc_length 10806	inbred	21	both	12wks	N=10	2003

Wahlsten1:7	Wahlsten1	histopathology	(none)	length of hippocampal commissure at mid-sagittal plane [mm] hc_length 10807	inbred	21	both	12wks	N=10	2003

Wahlsten1:9	Wahlsten1	histopathology	(none)	cross-sectional area of corpus callosum at midplane [mm²] cc_area 10809	inbred	21	both	12wks	N=10	2003

Wahlsten1:10	Wahlsten1	histopathology	(none)	cross-sectional area of hippocampal commissure at midplane [mm²] hc_area 10810	inbred	21	both	12wks	N=10	2003

Wahlsten1:12	Wahlsten1	histopathology	(none)	corpus callosum index (0=absent, 1=normal, <0.65 is abnormal) [score] cc_index 10812	inbred	21	both	12wks	N=10	2003

Wahlsten1:13	Wahlsten1	histopathology	(none)	hippocampal commissure index (0=absent, 1=normal, <0.5 is abnormal) [score] hc_index 10813	inbred	21	both	12wks	N=10	2003

Wahlsten1:40	Wahlsten1	elevated plus maze	(none)	distance traveled in 1 min [cm] dist_EPM 10840 1 2 3 4 5	inbred	21	both	9wks	N=9	2003

Wahlsten1:45	Wahlsten1	elevated plus maze	(none)	percentage of time spent moving; average of 5 min [%] pct_move 10845	inbred	21	both	9wks	N=9	2003

Wahlsten1:46	Wahlsten1	elevated plus maze	(none)	speed when moving; average over 5 min [cm/sec] speed_ave_EPM 10846	inbred	21	both	9wks	N=9	2003

Wahlsten1:52	Wahlsten1	elevated plus maze	(none)	percentage of time spent in open arms vs closed [%] pct_open 10852	inbred	21	both	9wks	N=9	2003

Wahlsten1:53	Wahlsten1	elevated plus maze	(none)	average distance traveled in 1 min [cm] dist_ave_EPM 10853	inbred	21	both	9wks	N=9	2003

Wahlsten1:55	Wahlsten1	elevated plus maze	(none)	time spent in two open arms [s] open 10855	inbred	21	both	9wks	N=9	2003

Willott1:1	Willott1	body weight	(none)	body weight [g] bw 9101	inbred w/CC7	40	both	5-6wks	N=8	2002

Wiltshire3:46	Wiltshire3	biomarker quantification	fluoxetine	cerebral cortex GSK3B, relative fluorescence intensity GSK3B 38146 control fluoxetine change index	inbred	30	m	10-11wks	N=3	2011

Wiltshire3:55	Wiltshire3	biomarker quantification	fluoxetine	cerebral cortex NGF, relative fluorescence intensity NGF 38155 control fluoxetine change index	inbred	30	m	10-11wks	N=3	2011

Wiltshire4:61	Wiltshire4	immune cell quantification	selumetinib	B cells, percent viability [%] Bcells_Sel 52461 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	34	m	10wks	N=4	2015

Wiltshire4:73	Wiltshire4	immune cell quantification	selumetinib	monocytes, percent viability [%] monocytes_Sel 52473 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	34	m	10wks	N=4	2015

Xing1:26	Xing1	ECG	(none)	interval QRS [ms] QRS 24926 6mo 12mo 20mo	inbred	29	both		N=7	2008

Yuan1:1	Yuan1	hormone quantification	(none)	insulin-like growth factor 1 (serum IGF-1) [ng/mL] IGF1 27001 6mo 12mo 18mo	inbred	33	both		N=7	2007

Zimmermann1:5	Zimmermann1	intake monitoring	(none)	food consumption, second day [g] food_intake 112168 during light during dark	inbred	30	both	7-15wks	N=11	2020

List measures where BTBR T+ Itpr3tf/J is an outlier

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List measures where BTBR T⁺ Itpr3^tf/J is an outlier