MPD: Data set: Paigen1

Paigen1 downloads
• Download Paigen1 project data set animal data, as uploaded
• Download Paigen1 animal data matrix with factor-related expansion applied as necessary
• Download Paigen1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Paigen1 measures:

MA:0000062 aorta
MA:0000356 gall bladder
MA:0000358 liver
MA:0002501 plasma
MA:0002513 bile
MP:0000180 abnormal circulating cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0000598 abnormal liver morphology
MP:0001259 abnormal body weight
MP:0001573 abnormal circulating alanine transaminase level
MP:0004773 abnormal bile composition
MP:0004774 abnormal bile salt level
MP:0004847 abnormal liver weight
MP:0005340 altered susceptibility to atherosclerosis
MP:0012776 abnormal liver cholesterol level
MP:0020098 abnormal susceptibility to diet-induced aortic fatty streak lesions
MP:0020131 abnormal gallbladder volume
MP:0020151 abnormal circulating non-HDL cholesterol level
VT:0000180 blood cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0000272 aorta morphology trait
VT:0000598 liver morphology trait
VT:0000609 liver physiology trait
VT:0001259 body mass
VT:0001547 lipid amount
VT:0001573 blood alanine transaminase amount
VT:0003402 liver mass
VT:0005084 gall bladder morphology trait
VT:0005086 bile amount
VT:0005675 gall bladder size trait
VT:0010474 blood non-HDL cholesterol amount
VT:0015078 blood homeostasis trait

Investigators	Beverly Paigen The Jackson Laboratory, Bar Harbor, ME Guylaine Bouchard Hopital Ste-Justine, Montreal, Quebec CANADA Martin C Carey Harvard Medical School, Boston, MA
Participants	Johnson D, Tovbina M, Silva A, Carver T, Tracy T, McFarland C, Archer J, Whitmore H
Contact	Beverly Paigen bev.paigen@jax.org
Affiliated Center	JAX Heart, Lung, and Blood Center (HLB)
Part of a series:	• Inbred strains (this project) Paigen1 • Obesity mutant strains see Paigen3
Acknowledgements	Funding provided by NIH DK51568, NHLBI PGA HL66611, DK36588, DK34854, DK52911; Medical Research Council of Canada Generous funds from Aventis Pharmaceuticals Inc. were used to defray the cost of mice through the Mouse Phenome Project.
Project type	Phenotype strain survey data set
MPD identifiers	Paigen1 MPD:29
Data changelog	8 updates/corrections. Initial release date: 02/2001.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

All animals were fed a high-fat (15% fat) diet for 8 wks. Blood chemistry and cholesterol were measured. After sac, a pathology review of livers and gallbladders was conducted. A collection of liver images is available as part of this project.

Procedures conducted:

• body weight		Baseline vs. high-fat diet for 8wks.
• lipid profile		Cholesterol, HDL, non-HDL. 4h fast, plasma. Hepatic lipids. 8wks on high-fat diet.
• metabolic panel		Alanine transaminase, bile salts (plasma) after 8wks on high-fat diet. 4h fast.
• histopathology		Gallstone, gallbladder, and atherosclerosis lesion histopathology after 8wks on high-fat diet.
• organ dimensions		Gallbladder volume after 8wks on high-fat diet.
• organ weights		Liver weight after 8wks on high-fat diet.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Paigen1:4	Paigen1	colony observation	(none)	age at start of diet (local parameter) [d] age 2904	inbred	41	both		N=10

Paigen1:5	Paigen1	body weight	high-fat diet	body weight [g] bw 2905 start after 8wks on diet fold change	inbred	43	both	7-11wks	N=12

Paigen1:7	Paigen1	organ weights	high-fat diet	liver weight at sacrifice [g] liverweight 2907	inbred	43	both	15-19wks	N=9

Paigen1:8	Paigen1	organ dimensions	high-fat diet	gallbladder volume [µL] gbvol 2908	inbred	43	both	15-19wks	N=8

Paigen1:9	Paigen1	histopathology	high-fat diet	gallbladder, mucin (score: 0-4) [score] mucin 2909	inbred	43	both	15-19wks	N=8

Paigen1:10	Paigen1	histopathology	high-fat diet	gallbladder, arc (score: 0-4) [score] arc 2910	inbred	43	both	15-19wks	N=8

Paigen1:11	Paigen1	histopathology	high-fat diet	gallbladder, filaments (score: 0-4) [score] filaments 2911	inbred	43	both	15-19wks	N=8

Paigen1:12	Paigen1	histopathology	high-fat diet	gallbladder, small liquid crystals (score: 0-4) [score] smallLC 2912	inbred	43	both	15-19wks	N=8

Paigen1:13	Paigen1	histopathology	high-fat diet	gallbladder, aggregated liquid crystals (score: 0-4) [score] agLC 2913	inbred	43	both	15-19wks	N=8

Paigen1:14	Paigen1	histopathology	high-fat diet	gallbladder, fused liquid crystals (score: 0-4) [score] fusedLC 2914	inbred	43	both	15-19wks	N=8

Paigen1:15	Paigen1	histopathology	high-fat diet	gallbladder, cholesterol monohydrate crystals (score: 0-4) [score] ChMC 2915	inbred	43	both	15-19wks	N=8

Paigen1:16	Paigen1	histopathology	high-fat diet	gallbladder, number of sandy stones [n] sandysto 2916	inbred	43	both	15-19wks	N=8

Paigen1:17	Paigen1	histopathology	high-fat diet	gallbladder, number of true gallstones [n] gs 2917	inbred	43	both	15-19wks	N=8

Paigen1:18	Paigen1	histopathology	high-fat diet	gallbladder, number of sandy plus true stones [n] nstones 2918	inbred	43	both	15-19wks	N=8

Paigen1:19	Paigen1	histopathology	high-fat diet	gallbladder, presence of stones (score: 1=present, 0=absent) [score] st_pres 2919	inbred	43	both	15-19wks	N=9

Paigen1:20	Paigen1	lipid profile	high-fat diet	total cholesterol (plasma) [mg/dL] totalCh 2920	inbred	43	both	15-19wks	N=9

Paigen1:21	Paigen1	lipid profile	high-fat diet	HDL cholesterol (plasma) [mg/dL] HDL_Ch 2921	inbred	43	both	15-19wks	N=9

Paigen1:22	Paigen1	lipid profile	high-fat diet	plasma cholesterol not in the HDL fraction [mg/dL] nonHDL_Ch 2922	inbred	43	both	15-19wks	N=8

Paigen1:23	Paigen1	lipid profile	high-fat diet	percentage of total plasma cholesterol in HDL fraction [%] pctHDL_TCH 2923	inbred	43	both	15-19wks	N=8

Paigen1:24	Paigen1	metabolic panel	high-fat diet	alanine transaminase (plasma ALT) [IU/L] ALT 2924	inbred	43	both	15-19wks	N=8

Paigen1:25	Paigen1	metabolic panel	high-fat diet	bile salts (plasma) [µmol/L] bilesalts 2925	inbred	43	both	15-19wks	N=8

Paigen1:26	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (free per g liver) [mg] freeHCC 2926	inbred	43	both	15-19wks	N=6

Paigen1:27	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (esterified per g liver) [mg] estHCC 2927	inbred	43	both	15-19wks	N=6

Paigen1:28	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (total per g liver) [mg] totHCC 2928	inbred	43	both	15-19wks	N=8

Paigen1:29	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (free to esterified ratio) [ratio] free_to_est 2929	inbred	43	both	15-19wks	N=6

Paigen1:30	Paigen1	histopathology	high-fat diet	liver microvacuoles (score: 0-4) [score] microvacs 2930	inbred	43	both	15-19wks	N=3

Paigen1:31	Paigen1	histopathology	high-fat diet	liver macrovacuoles (score: 0-4) [score] macrovacs 2931	inbred	43	both	15-19wks	N=3

Paigen1:32	Paigen1	histopathology	high-fat diet	liver inflammation (score: 0-4) [score] inflammation 2932	inbred	43	both	15-19wks	N=3

Paigen1:36	Paigen1	histopathology	high-fat diet	fatty streak aortic lesion size [µm²] aortic_lesion 2936	inbred	44	both	15-19wks	N=8

Paigen1: Diet effects on gallstone formation and the assessment of liver morphology, plasma lipids, and atherosclerosis in 44 inbred strains of mice on high-fat atherogenic diet (not under pathogen-free conditions) (2000)

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