MPD: Phenotype measures mapped to MA:0000141, spleen

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Ankra-Badu1:10	Ankra-Badu1	organ weights	(none)	spleen weight [mg] SPLEEN 21210	QTL population		both	10wks	N=502	2009

Auwerx2:135	Auwerx2	organ weights	(none)	spleen weight [g] spleen_wt 114663 CD HFD	inbred w/CC8	9	both	21wks	N=4	2021

Benoist1:1	Benoist1	immune cell quantification	(none)	percentage of thymic CD4 Treg cells that are CD25^hi [%] Treg_thy_CD25 25801	inbred	33	m	5-6wks	N=3	2007

Benoist1:2	Benoist1	immune cell quantification	(none)	percentage of thymic CD4 Treg cells that are Foxp3+ [%] Treg_thy_Foxp3 25802	inbred	10	m	5-6wks	N=3	2007

Benoist1:3	Benoist1	immune cell quantification	(none)	percentage of splenic CD4 Treg cells that are CD25^hi [%] Treg_spl_CD25 25803	inbred	31	m	5-6wks	N=3	2007

Benoist1:4	Benoist1	immune cell quantification	(none)	percentage of splenic CD4 Treg cells that are Foxp3+ [%] Treg_spl_Foxp3 25804	inbred	10	m	5-6wks	N=3	2007

Bopp1:5	Bopp1	health assessment	Plasmodium berghei	percentage of parasites in spleen relative to all organs tested [%] luciferase_spleen 36405	inbred	28	both	8-12wks	N=2	2010

Brockmann1:11	Brockmann1	organ weights	(none)	weight of spleen [mg] Spleen 21311	QTL population		both	6wks	N=138	2009

Brockmann1:28	Brockmann1	organ weights	(none)	weight of spleen [mg] spleen 21508	QTL population		both	6wks	N=201	2009

Chen1:3	Chen1	immune cell quantification	(none)	percentage of total TCRβ+ cells that are invariant NK T cells, spleen [%] pct_iNKT_T_spleen 52303	inbred	38	m	8-10wks	N=4	2011

Chen1:4	Chen1	immune cell quantification	(none)	percentage of invariant NK T cells that express CD4, spleen [%] pct_iNKT_CD4_spleen 52304	inbred	35	m	8-10wks	N=4	2011

Chen1:5	Chen1	immune cell quantification	(none)	peripheral blood to spleen ratio of invariant NK T cells [ratio] iNKT_pb_spl_ratio 52305	inbred	38	m	8-10wks	N=4	2011

Chesler3:99	Chesler3	organ weights	(none)	spleen weight [g] spleen_wt 43599	CC pre w/par	263	both	7-15wks	N=2	2011

Cheverud1:21	Cheverud1	organ weights	high-fat diet	spleen weight as percentage of body weight [%] spleenwt_adj 17822 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8	2004

Farmer1:23	Farmer1	organ weights	(none)	spleen weight [g] SpleenWeight 11323	QTL population		both	6wks	N=206	2001

Farmer1:24	Farmer1	organ weights	(none)	spleen/body weight ratio [%] SplBW 11324	QTL population		both	6wks	N=206	2001

GMC21:5	GMC21	organ weights	(none)	spleen weight [g] spleen_wt 57005	inbred w/CC8	8	both	21wks	N=11	2018

Graham1:33	Graham1	immune cell quantification	West Nile virus	percentage of CD3+ T cells that are CD4+ in spleen, post infection [%] CD4_spleen 63333 day 7 day 12 day 21 day 28	CC RIX	2	m	8-10wks	N=3	2015

Graham1:41	Graham1	immune cell quantification	West Nile virus	percentage of CD4+ T cells that are Foxp3+ in the spleen, post infection [%] Treg_spleen 63341 day 7 day 12 day 21 day 28	CC RIX	2	m	8-10wks	N=3	2015

Graham1:49	Graham1	immune cell quantification	West Nile virus	percentage of CD3+ T cells that are CD8+ in spleen, post infection [%] CD8_spleen 63349 day 7 day 12 day 21 day 28	CC RIX	2	m	8-10wks	N=3	2015

Graham1:57	Graham1	immune cell quantification	West Nile virus	percentage of CD3+ T cells that are NS4b+ in spleen, post infection [%] NS4b_spleen 63357 day 7 day 12 day 21 day 28	CC RIX	2	m	8-10wks	N=3	2015

Graham1:72	Graham1	RNA expression profiling	West Nile virus	virus in spleen, fold change compared to matched control, post infection WNV_spleen 63372 day 2 day 4 day 7 day 12	CC RIX	5	m	8-10wks	N=1	2015

Graham1:83	Graham1	RNA expression profiling	West Nile virus	Ifnb1 gene expression in spleen, fold change compared to matched control, post infection Ifnb1_spleen 63383 day 2 day 4 day 7 day 12	CC RIX	5	m	8-10wks	N=1	2015

Graham1:94	Graham1	RNA expression profiling	West Nile virus	Ifit1 gene expression in spleen, fold change compared to matched control, post infection Ifit1_spleen 63394 day 2 day 4 day 7 day 12	CC RIX	5	m	8-10wks	N=1	2015

Graham3:9	Graham3	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD4+ T cells [%] CD4_pos_tot 113800	CC RIX	102	m	8-10wks	N=4	2021

Graham3:10	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are Foxp3+ (Treg) [%] Tregs 113801	CC RIX	102	m	8-10wks	N=4	2021

Graham3:11	Graham3	immune cell quantification	(none)	percentage of splenic Treg cells that are CD29+ [%] Treg_CD29_pos 113802	CC RIX	102	m	8-10wks	N=4	2021

Graham3:12	Graham3	immune cell quantification	(none)	percentage of splenic Treg cells that are CD44hi [%] Treg_CD44_hi 113803	CC RIX	102	m	8-10wks	N=4	2021

Graham3:13	Graham3	immune cell quantification	(none)	percentage of splenic Treg cells that are CD73+ [%] Treg_CD73_pos 113804	CC RIX	102	m	8-10wks	N=4	2021

Graham3:14	Graham3	immune cell quantification	(none)	percentage of splenic Treg cells that are CTLA-4+ [%] Treg_CTLA4_pos 113805	CC RIX	102	m	8-10wks	N=4	2021

Graham3:15	Graham3	immune cell quantification	(none)	percentage of splenic Treg cells that are CXCR3+ [%] Treg_CXCR3_pos 113806	CC RIX	102	m	8-10wks	N=4	2021

Graham3:16	Graham3	immune cell quantification	(none)	percentage of splenic Treg cells that are ICOS+ (inducible costimulator) [%] Treg_ICOS_pos 113807	CC RIX	102	m	8-10wks	N=4	2021

Graham3:21	Graham3	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD3+ T cells (memory precursor panel) [%] mp_CD3_pos 113812	CC RIX	92	m	8-10wks	N=4	2021

Graham3:22	Graham3	immune cell quantification	(none)	percentage of splenic CD3+ T cells that are CD8+ (memory precursor panel) [%] mp_CD3_pos_CD8_pos 113813	CC RIX	92	m	8-10wks	N=4	2021

Graham3:23	Graham3	immune cell quantification	(none)	percentage of splenic CD8+ T cells that are CD44+ (memory precursor panel) [%] mp_CD8_pos_CD44_pos 113814	CC RIX	91	m	8-10wks	N=4	2021

Graham3:24	Graham3	immune cell quantification	(none)	percentage of splenic CD8+ T cells that are CD62L- (memory precursor panel) [%] mp_CD8_pos_CD62L_neg 113815	CC RIX	76	m	8-10wks	N=3	2021

Graham3:25	Graham3	immune cell quantification	(none)	percentage of splenic CD8+ T cells that are Ki67+ (memory precursor panel) [%] mp_CD8_pos_Ki67_pos 113816	CC RIX	92	m	8-10wks	N=4	2021

Graham3:26	Graham3	immune cell quantification	(none)	percentage of splenic CD3+ T cells that are CD4+ (memory precursor panel) [%] mp_CD3_pos_CD4_pos 113817	CC RIX	92	m	8-10wks	N=4	2021

Graham3:27	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are CD44+ (memory precursor panel) [%] mp_CD4_pos_CD44_pos 113818	CC RIX	91	m	8-10wks	N=4	2021

Graham3:28	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are CD62L- (memory precursor panel) [%] mp_CD4_pos_CD62L_neg 113819	CC RIX	73	m	8-10wks	N=3	2021

Graham3:29	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are Ki67+ (memory precursor panel) [%] mp_CD4_pos_Ki67_pos 113820	CC RIX	92	m	8-10wks	N=4	2021

Graham3:34	Graham3	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD3+ T cells (memory panel) [%] mem_CD3_pos 113825	CC RIX	68	m	8-10wks	N=3	2021

Graham3:35	Graham3	immune cell quantification	(none)	percentage of splenic CD3+ T cells that are CD8+ (memory panel) [%] mem_CD3_pos_CD8_pos 113826	CC RIX	68	m	8-10wks	N=3	2021

Graham3:36	Graham3	immune cell quantification	(none)	percentage of splenic CD8+ T cells that are CD44+ (memory panel) [%] mem_CD8_pos_CD44_pos 113827	CC RIX	73	m	8-10wks	N=3	2021

Graham3:37	Graham3	immune cell quantification	(none)	percentage of splenic CD8+ T cells that are CD62L- (memory panel) [%] mem_CD8_pos_CD62L_neg 113828	CC RIX	68	m	8-10wks	N=3	2021

Graham3:38	Graham3	immune cell quantification	(none)	percentage of splenic CD8+ T cells that are Ki67+ (memory panel) [%] mem_CD8_pos_Ki67_pos 113829	CC RIX	73	m	8-10wks	N=3	2021

Graham3:39	Graham3	immune cell quantification	(none)	percentage of splenic CD3+ T cells that are CD4+ (memory panel) [%] mem_CD3_pos_CD4_pos 113830	CC RIX	68	m	8-10wks	N=3	2021

Graham3:40	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are CD44+ (memory panel) [%] mem_CD4_pos_CD44_pos 113831	CC RIX	73	m	8-10wks	N=3	2021

Graham3:41	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are CD62L- (memory panel) [%] mem_CD4_pos_CD62L_neg 113832	CC RIX	68	m	8-10wks	N=3	2021

Graham3:42	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are Ki67+ (memory panel) [%] mem_CD4_pos_Ki67_pos 113833	CC RIX	73	m	8-10wks	N=3	2021

Graham3:47	Graham3	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD3+ T cells following stimulation with anti-CD3 and anti CD28 [%] ics_CD3_pos 113838	CC RIX	102	m	8-10wks	N=4	2021

Graham3:48	Graham3	immune cell quantification	(none)	percentage of splenic CD3+ T cells that are CD8+ following stimulation with anti-CD3 and anti-CD28 [%] ics_CD3_pos_CD8_pos 113839	CC RIX	102	m	8-10wks	N=4	2021

Graham3:49	Graham3	immune cell quantification	(none)	percentage of splenic CD8+ T cells that are IL-17+ by intracellular cytokine staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD8_pos_IL17_pos 113840	CC RIX	102	m	8-10wks	N=4	2021

Graham3:50	Graham3	immune cell quantification	(none)	percentage of splenic CD8+ T cells that are IFNg+ by intracellular cytokine staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD8_pos_IGNg_pos 113841	CC RIX	102	m	8-10wks	N=4	2021

Graham3:51	Graham3	immune cell quantification	(none)	percentage of splenic CD3+ T cells that are CD4+ following stimulation with anti-CD3 and anti-CD28 [%] ics_CD3_pos_CD4_pos 113842	CC RIX	102	m	8-10wks	N=4	2021

Graham3:52	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are IL-17+ by intracellular cytokine staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD4_pos_IL17_pos 113843	CC RIX	102	m	8-10wks	N=4	2021

Graham3:53	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are IFNg+ by intracellular cytokine staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD4_pos_IFNg_pos 113844	CC RIX	102	m	8-10wks	N=4	2021

Graham3:54	Graham3	immune cell quantification	(none)	percentage of splenic CD4+ T cells that are Tbet+ (transcription factor) by intracellular staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD4_pos_Tbet_pos 113845	CC RIX	92	m	8-10wks	N=4	2021

Harrill1:11	Harrill1	organ weights	isoniazid	spleen weight [g] spleen 39511 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill1:13	Harrill1	organ weights	isoniazid	spleen weight as percentage of body weight [%] pct_spleen 39513 control isoniazid	inbred	34	f	8-10wks	N=4	2011

JaxKOMP-EAP:446	JaxKOMP-EAP	organ weights	(none)	spleen weight [g] spleen_weight 100707	KOMP	132	both	18wks	N=2	2016

Jaxpheno2:40	Jaxpheno2	organ weights	(none)	spleen weight [g] spleen 22740 age 8wks age 16wks	inbred	11	both		N=8	2006

Jaxpheno2:42	Jaxpheno2	organ weights	(none)	spleen weight, as percentage of body weight [%] pct_spleen 22742 age 8wks age 16wks	inbred	11	both		N=8	2006

Jaxpheno6:1	Jaxpheno6	immune cell quantification	(none)	splenic CD4 T cells (percentage of total viable cells) [%] pct_CD4 23101 8wks 16wks	inbred	11	both		N=9	2006

Jaxpheno6:3	Jaxpheno6	immune cell quantification	(none)	splenic CD8 T cells (percentage of total viable cells) [%] pct_CD8 23103 8wks 16wks	inbred	11	both		N=9	2006

Jaxpheno6:5	Jaxpheno6	immune cell quantification	(none)	splenic NK T cells (percentage of total viable cells) [%] pct_NKT 23105 8wks 16wks	inbred	11	both		N=9	2006

Jaxpheno6:7	Jaxpheno6	immune cell quantification	(none)	splenic NK cells (percentage of total viable cells) [%] pct_NK 23107 8wks 16wks	inbred	11	both		N=9	2006

Jaxpheno6:9	Jaxpheno6	immune cell quantification	(none)	splenic B cells (percentage of total viable cells) [%] pct_B 23109 8wks 16wks	inbred	11	both		N=9	2006

Jaxpheno6:20	Jaxpheno6	immune cell quantification	(none)	splenic granulocytes (percentage of total viable cells) [%] pct_Granu 23120 8wks 16wks	inbred	11	both		N=9	2006

Jaxpheno6:22	Jaxpheno6	immune cell quantification	(none)	splenic monocytes (percentage of total viable cells) [%] pct_Mono 23122 8wks 16wks	inbred	11	both		N=9	2006

Lesage1:1	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD3- [%] CD3_neg 63501	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:2	Lesage1	immune cell quantification	(none)	percentage of splenic CD3- lymphocytes that are NK cells (CD49+ CD19-) [%] NK_cells_of_CD3_neg 63502	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:3	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are NK cells (CD49+ CD19-) [%] NK_cells_of_tot 63503	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:4	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are CD27- CD11b- [%] CD27_neg_CD11b_neg 63504	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:5	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are CD27+ CD11b- [%] CD27_pos_CD11b_neg 63505	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:6	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are CD27+ CD11b+ [%] CD27_pos_CD11b_pos 63506	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:7	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are CD27- CD11b+ [%] CD27_neg_CD11b_pos 63507	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:8	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are pre-mNK (B220+ CD11c+) [%] pre_mNK_of_NK 63508	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:9	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are pre-mNK (B220+ CD11c+) [%] pre_mNK_of_tot 63509	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:10	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are NK T cells (TCRb+ CD1d+) [%] NKT_cells 63510	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:11	Lesage1	immune cell quantification	(none)	percentage of splenic NK T cells that are CD4+ CD8- [%] CD4_pos_CD8_neg_of_NKT 63511	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:12	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD4+ NK T cells [%] CD4_pos_CD8_neg_NKT_of_tot 63512	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:13	Lesage1	immune cell quantification	(none)	percentage of splenic NK T cells that are CD4- CD8- [%] CD4_neg_CD8_neg_of_NKT 63513	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:14	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD4- CD8- NK T cells [%] CD4_neg_CD8_neg_NKT_of_tot 63514	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:15	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are T cells [%] T_cells 63515	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:16	Lesage1	immune cell quantification	(none)	percentage of splenic T cells that are CD4+ CD8- [%] CD4_pos_CD8_neg_of_Tcells 63516	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:17	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD4+ T cells [%] CD4_pos_CD8_neg_of_tot 63517	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:18	Lesage1	immune cell quantification	(none)	percentage of splenic T cells that are CD4- CD8+ [%] CD4_neg_CD8_pos_of_Tcells 63518	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:19	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD8+ T cells [%] CD4_neg_CD8_pos_of_tot 63519	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:20	Lesage1	immune cell quantification	(none)	percentage of splenic T cells that are CD4- CD8- [%] CD4_neg_CD8_neg_of_Tcells 63520	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:21	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD4- CD8- T cells [%] CD4_neg_CD8_neg_of_tot 63521	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:22	Lesage1	immune cell quantification	(none)	ratio of splenic CD4+ to CD8+ T cells [ratio] CD4_CD8_ratio 63522	CC w/par	76	both	5-8wks	N=2	2018

Lesage1:23	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are plasmacytoid dendritic cells [%] pDC 63523	CC w/par	74	both	5-8wks	N=2	2018

Lesage1:24	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are conventional dendritic cells [%] cDC 63524	CC w/par	74	both	5-8wks	N=2	2018

Lesage1:25	Lesage1	immune cell quantification	(none)	percentage of splenic conventional dendritic cells that are merocytic [%] mDC_of_cDC 63525	CC w/par	74	both	5-8wks	N=2	2018

Lesage1:26	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are merocytic dendritic cells [%] mDC_of_tot 63526	CC w/par	74	both	5-8wks	N=2	2018

Lesage1:27	Lesage1	immune cell quantification	(none)	percentage of splenic conventional dendritic cells that are cDC1 [%] cDC1_of_cDC 63527	CC w/par	74	both	5-8wks	N=2	2018

Lesage1:28	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are cDC1 conventional dendritic cells [%] cDC1_of_tot 63528	CC w/par	74	both	5-8wks	N=2	2018

Lesage1:29	Lesage1	immune cell quantification	(none)	percentage of splenic conventional dendritic cells that are cDC2 [%] cDC2_of_cDC 63529	CC w/par	74	both	5-8wks	N=2	2018

Lesage1:30	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are cDC2 conventional dendritic cells [%] cDC2_of_tot 63530	CC w/par	74	both	5-8wks	N=2	2018

Lesage2:9	Lesage2	immune cell quantification	(none)	total number of splenic lymphocytes (x 10⁶) [n] spleen_cells_tot 131924	CC w/par	76	both	5-8wks	N=2	2024

Lesage2:10	Lesage2	immune cell quantification	(none)	number of B cells in spleen (x 10⁶) [n] B_cells_tot 131925	CC w/par	76	both	5-8wks	N=2	2024

Lesage2:11	Lesage2	immune cell quantification	(none)	percentage of splenic lymphocytes that are B cells (CD3-CD49b-B220+CD19+) [%] B_cells_pct 131926	CC w/par	76	both	5-8wks	N=2	2024

Mahler1:1	Mahler1	organ weights	(none)	spleen to body weight ratio, first Principal Component [ratio] SplBW 12101	QTL population		both	6wks	N=102	2002

Mills1:5	Mills1	apoptosis assessment	(none)	early apoptotic splenocytes [%] early_apoptotic 25205 6mo 12mo 20mo	inbred	30	both		N=3	2008

Mills1:11	Mills1	apoptosis assessment	(none)	late apoptotic splenocytes [%] late_apoptotic 25211 6mo 12mo 20mo	inbred	30	both		N=3	2008

Mills1:17	Mills1	apoptosis assessment	(none)	all apoptotic splenocytes [%] all_apoptotic 25217 6mo 12mo 20mo	inbred	30	both		N=3	2008

Reed2:56	Reed2	organ weights	(none)	spleen weight [g] spleen_wt 53156	B6.129 and 129.B6 consomic w/par	9	both	26wks	N=17	2015

Rodriguez1:1	Rodriguez1	in vitro assay	(none)	spleen and liver murine cytomegalovirus genome levels (normalized to endogenous b-actin) [ratio] CMV_LEVELS 24101	QTL population		both	8-12wks	N=92	2009

Schoonjans1:222	Schoonjans1	organ weights	high-fat diet	spleen weight [g] spleen_wt 112857 CD HFD	BXD w/par	35	m	29wks	N=5	2021

Svenson7:329	Svenson7	body weight	(none)	spleen weight [g] spleen_wt 121575 chow hfhs	DO population		both	26-30wks	N=167	2020

Williams1:1	Williams1	immune cell quantification	(none)	CD4 Treg cells (CD25+ CD44^int; as percentage of lymphocytes) [%] Treg 42901	inbred	5	f	8wks	N=3	2012

Williams1:2	Williams1	immune cell quantification	(none)	CD4 Treg cells (CD25+ CD44^int; as percentage of CD4 T cells) [%] Treg_adj 42902	inbred	5	f	8wks	N=3	2012

Williams1:3	Williams1	immune cell quantification	(none)	memory-effector CD4 T cells (CD25^- CD44^hi; as percentage of lymphocytes) [%] memoryT 42903	inbred	5	f	8wks	N=3	2012

Williams1:4	Williams1	immune cell quantification	(none)	memory-effector CD4 T cells (CD25^- CD44^hi; as percentage of CD4 T cells) [%] memoryT_adj 42904	inbred	5	f	8wks	N=3	2012

Williams1:5	Williams1	immune cell quantification	(none)	naive CD4 T cells (CD25^- CD44^lo; as percentage of lymphocytes) [%] naiveT 42905	inbred	5	f	8wks	N=3	2012

Williams1:6	Williams1	immune cell quantification	(none)	naive CD4 T cells (CD25^- CD44^lo; as percentage of CD4 T cells) [%] naiveT_adj 42906	inbred	5	f	8wks	N=3	2012

Wiltshire4:1	Wiltshire4	immune cell quantification	BEZ235	B cells, percent viability [%] Bcells_BEZ 52401 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	34	m	10wks	N=4	2015

Wiltshire4:7	Wiltshire4	immune cell quantification	BEZ235	T cells, percent viability [%] Tcells_BEZ 52407 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	34	m	10wks	N=4	2015

Wiltshire4:13	Wiltshire4	immune cell quantification	BEZ235	monocytes, percent viability [%] monocytes_BEZ 52413 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	34	m	10wks	N=4	2015

Wiltshire4:21	Wiltshire4	immune cell quantification	doxorubicin	B cells, percent viability [%] Bcells_Dox 52421 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	35	m	10wks	N=4	2015

Wiltshire4:27	Wiltshire4	immune cell quantification	doxorubicin	T cells, percent viability [%] Tcells_Dox 52427 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	35	m	10wks	N=4	2015

Wiltshire4:33	Wiltshire4	immune cell quantification	doxorubicin	monocytes, percent viability [%] monocytes_Dox 52433 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	35	m	10wks	N=4	2015

Wiltshire4:41	Wiltshire4	immune cell quantification	idarubicin	B cells, percent viability [%] Bcells_Ida 52441 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	35	m	10wks	N=4	2015

Wiltshire4:47	Wiltshire4	immune cell quantification	idarubicin	T cells, percent viability [%] Tcells_Ida 52447 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	35	m	10wks	N=4	2015

Wiltshire4:53	Wiltshire4	immune cell quantification	idarubicin	monocytes, percent viability [%] monocytes_Ida 52453 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	35	m	10wks	N=4	2015

Wiltshire4:61	Wiltshire4	immune cell quantification	selumetinib	B cells, percent viability [%] Bcells_Sel 52461 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	34	m	10wks	N=4	2015

Wiltshire4:67	Wiltshire4	immune cell quantification	selumetinib	T cells, percent viability [%] Tcells_Sel 52467 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	34	m	10wks	N=4	2015

Wiltshire4:73	Wiltshire4	immune cell quantification	selumetinib	monocytes, percent viability [%] monocytes_Sel 52473 dose [µM]: control 0.046 0.137 1.235 11.1 100	inbred w/CC7	34	m	10wks	N=4	2015

Ankra-Badu1

organ weights

(none)

spleen weight [mg] SPLEEN 21210

QTL population

both

10wks

N=502

2009

Auwerx2

organ weights

(none)

spleen weight [g] spleen_wt 114663 CD HFD

inbred w/CC8

9

both

21wks

N=4

2021

Benoist1

immune cell quantification

(none)

percentage of thymic CD4 Treg cells that are CD25^hi [%] Treg_thy_CD25 25801

inbred

33

m

5-6wks

N=3

2007

Benoist1

immune cell quantification

(none)

percentage of thymic CD4 Treg cells that are Foxp3+ [%] Treg_thy_Foxp3 25802

inbred

10

m

5-6wks

N=3

2007

Benoist1

immune cell quantification

(none)

percentage of splenic CD4 Treg cells that are CD25^hi [%] Treg_spl_CD25 25803

inbred

31

m

5-6wks

N=3

2007

Benoist1

immune cell quantification

(none)

percentage of splenic CD4 Treg cells that are Foxp3+ [%] Treg_spl_Foxp3 25804

inbred

10

m

5-6wks

N=3

2007

Bopp1

health assessment

Plasmodium berghei

percentage of parasites in spleen relative to all organs tested [%] luciferase_spleen 36405

inbred

28

both

8-12wks

N=2

2010

Brockmann1

organ weights

(none)

weight of spleen [mg] Spleen 21311

QTL population

both

6wks

N=138

2009

Brockmann1

organ weights

(none)

weight of spleen [mg] spleen 21508

QTL population

both

6wks

N=201

2009

Chen1

immune cell quantification

(none)

percentage of total TCRβ+ cells that are invariant NK T cells, spleen [%] pct_iNKT_T_spleen 52303

inbred

38

m

8-10wks

N=4

2011

Chen1

immune cell quantification

(none)

percentage of invariant NK T cells that express CD4, spleen [%] pct_iNKT_CD4_spleen 52304

inbred

35

m

8-10wks

N=4

2011

Chen1

immune cell quantification

(none)

peripheral blood to spleen ratio of invariant NK T cells [ratio] iNKT_pb_spl_ratio 52305

inbred

38

m

8-10wks

N=4

2011

Chesler3

organ weights

(none)

spleen weight [g] spleen_wt 43599

CC pre w/par

263

both

7-15wks

N=2

2011

Cheverud1

organ weights

high-fat diet

spleen weight as percentage of body weight [%] spleenwt_adj 17822 control diet high-fat diet

LGXSM w/par

17

both

20-30wks

N=8

2004

Farmer1

organ weights

(none)

spleen weight [g] SpleenWeight 11323

QTL population

both

6wks

N=206

2001

Farmer1

organ weights

(none)

spleen/body weight ratio [%] SplBW 11324

QTL population

both

6wks

N=206

2001

GMC21

organ weights

(none)

spleen weight [g] spleen_wt 57005

inbred w/CC8

8

both

21wks

N=11

2018

Graham1

immune cell quantification

West Nile virus

percentage of CD3+ T cells that are CD4+ in spleen, post infection [%] CD4_spleen 63333 day 7 day 12 day 21 day 28

CC RIX

2

m

8-10wks

N=3

2015

Graham1

immune cell quantification

West Nile virus

percentage of CD4+ T cells that are Foxp3+ in the spleen, post infection [%] Treg_spleen 63341 day 7 day 12 day 21 day 28

CC RIX

2

m

8-10wks

N=3

2015

Graham1

immune cell quantification

West Nile virus

percentage of CD3+ T cells that are CD8+ in spleen, post infection [%] CD8_spleen 63349 day 7 day 12 day 21 day 28

CC RIX

2

m

8-10wks

N=3

2015

Graham1

immune cell quantification

West Nile virus

percentage of CD3+ T cells that are NS4b+ in spleen, post infection [%] NS4b_spleen 63357 day 7 day 12 day 21 day 28

CC RIX

2

m

8-10wks

N=3

2015

Graham1

RNA expression profiling

West Nile virus

virus in spleen, fold change compared to matched control, post infection WNV_spleen 63372 day 2 day 4 day 7 day 12

CC RIX

5

m

8-10wks

N=1

2015

Graham1

RNA expression profiling

West Nile virus

Ifnb1 gene expression in spleen, fold change compared to matched control, post infection Ifnb1_spleen 63383 day 2 day 4 day 7 day 12

CC RIX

5

m

8-10wks

N=1

2015

Graham1

RNA expression profiling

West Nile virus

Ifit1 gene expression in spleen, fold change compared to matched control, post infection Ifit1_spleen 63394 day 2 day 4 day 7 day 12

CC RIX

5

m

8-10wks

N=1

2015

Graham3

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD4+ T cells [%] CD4_pos_tot 113800

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are Foxp3+ (Treg) [%] Tregs 113801

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic Treg cells that are CD29+ [%] Treg_CD29_pos 113802

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic Treg cells that are CD44hi [%] Treg_CD44_hi 113803

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic Treg cells that are CD73+ [%] Treg_CD73_pos 113804

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic Treg cells that are CTLA-4+ [%] Treg_CTLA4_pos 113805

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic Treg cells that are CXCR3+ [%] Treg_CXCR3_pos 113806

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic Treg cells that are ICOS+ (inducible costimulator) [%] Treg_ICOS_pos 113807

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD3+ T cells (memory precursor panel) [%] mp_CD3_pos 113812

CC RIX

92

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD3+ T cells that are CD8+ (memory precursor panel) [%] mp_CD3_pos_CD8_pos 113813

CC RIX

92

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD8+ T cells that are CD44+ (memory precursor panel) [%] mp_CD8_pos_CD44_pos 113814

CC RIX

91

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD8+ T cells that are CD62L- (memory precursor panel) [%] mp_CD8_pos_CD62L_neg 113815

CC RIX

76

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD8+ T cells that are Ki67+ (memory precursor panel) [%] mp_CD8_pos_Ki67_pos 113816

CC RIX

92

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD3+ T cells that are CD4+ (memory precursor panel) [%] mp_CD3_pos_CD4_pos 113817

CC RIX

92

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are CD44+ (memory precursor panel) [%] mp_CD4_pos_CD44_pos 113818

CC RIX

91

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are CD62L- (memory precursor panel) [%] mp_CD4_pos_CD62L_neg 113819

CC RIX

73

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are Ki67+ (memory precursor panel) [%] mp_CD4_pos_Ki67_pos 113820

CC RIX

92

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD3+ T cells (memory panel) [%] mem_CD3_pos 113825

CC RIX

68

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD3+ T cells that are CD8+ (memory panel) [%] mem_CD3_pos_CD8_pos 113826

CC RIX

68

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD8+ T cells that are CD44+ (memory panel) [%] mem_CD8_pos_CD44_pos 113827

CC RIX

73

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD8+ T cells that are CD62L- (memory panel) [%] mem_CD8_pos_CD62L_neg 113828

CC RIX

68

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD8+ T cells that are Ki67+ (memory panel) [%] mem_CD8_pos_Ki67_pos 113829

CC RIX

73

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD3+ T cells that are CD4+ (memory panel) [%] mem_CD3_pos_CD4_pos 113830

CC RIX

68

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are CD44+ (memory panel) [%] mem_CD4_pos_CD44_pos 113831

CC RIX

73

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are CD62L- (memory panel) [%] mem_CD4_pos_CD62L_neg 113832

CC RIX

68

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are Ki67+ (memory panel) [%] mem_CD4_pos_Ki67_pos 113833

CC RIX

73

m

8-10wks

N=3

2021

Graham3

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD3+ T cells following stimulation with anti-CD3 and anti CD28 [%] ics_CD3_pos 113838

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD3+ T cells that are CD8+ following stimulation with anti-CD3 and anti-CD28 [%] ics_CD3_pos_CD8_pos 113839

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD8+ T cells that are IL-17+ by intracellular cytokine staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD8_pos_IL17_pos 113840

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD8+ T cells that are IFNg+ by intracellular cytokine staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD8_pos_IGNg_pos 113841

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD3+ T cells that are CD4+ following stimulation with anti-CD3 and anti-CD28 [%] ics_CD3_pos_CD4_pos 113842

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are IL-17+ by intracellular cytokine staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD4_pos_IL17_pos 113843

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are IFNg+ by intracellular cytokine staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD4_pos_IFNg_pos 113844

CC RIX

102

m

8-10wks

N=4

2021

Graham3

immune cell quantification

(none)

percentage of splenic CD4+ T cells that are Tbet+ (transcription factor) by intracellular staining following stimulation with anti-CD3 and anti-CD28 [%] ics_CD4_pos_Tbet_pos 113845

CC RIX

92

m

8-10wks

N=4

2021

Harrill1

organ weights

isoniazid

spleen weight [g] spleen 39511 control isoniazid

inbred

34

f

8-10wks

N=4

2011

Harrill1

organ weights

isoniazid

spleen weight as percentage of body weight [%] pct_spleen 39513 control isoniazid

inbred

34

f

8-10wks

N=4

2011

JaxKOMP-EAP

organ weights

(none)

spleen weight [g] spleen_weight 100707

KOMP

132

both

18wks

N=2

2016

Jaxpheno2

organ weights

(none)

spleen weight [g] spleen 22740 age 8wks age 16wks

inbred

11

both

N=8

2006

Jaxpheno2

organ weights

(none)

spleen weight, as percentage of body weight [%] pct_spleen 22742 age 8wks age 16wks

inbred

11

both

N=8

2006

Jaxpheno6

immune cell quantification

(none)

splenic CD4 T cells (percentage of total viable cells) [%] pct_CD4 23101 8wks 16wks

inbred

11

both

N=9

2006

Jaxpheno6

immune cell quantification

(none)

splenic CD8 T cells (percentage of total viable cells) [%] pct_CD8 23103 8wks 16wks

inbred

11

both

N=9

2006

Jaxpheno6

immune cell quantification

(none)

splenic NK T cells (percentage of total viable cells) [%] pct_NKT 23105 8wks 16wks

inbred

11

both

N=9

2006

Jaxpheno6

immune cell quantification

(none)

splenic NK cells (percentage of total viable cells) [%] pct_NK 23107 8wks 16wks

inbred

11

both

N=9

2006

Jaxpheno6

immune cell quantification

(none)

splenic B cells (percentage of total viable cells) [%] pct_B 23109 8wks 16wks

inbred

11

both

N=9

2006

Jaxpheno6

immune cell quantification

(none)

splenic granulocytes (percentage of total viable cells) [%] pct_Granu 23120 8wks 16wks

inbred

11

both

N=9

2006

Jaxpheno6

immune cell quantification

(none)

splenic monocytes (percentage of total viable cells) [%] pct_Mono 23122 8wks 16wks

inbred

11

both

N=9

2006

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD3- [%] CD3_neg 63501

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic CD3- lymphocytes that are NK cells (CD49+ CD19-) [%] NK_cells_of_CD3_neg 63502

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are NK cells (CD49+ CD19-) [%] NK_cells_of_tot 63503

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic NK cells that are CD27- CD11b- [%] CD27_neg_CD11b_neg 63504

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic NK cells that are CD27+ CD11b- [%] CD27_pos_CD11b_neg 63505

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic NK cells that are CD27+ CD11b+ [%] CD27_pos_CD11b_pos 63506

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic NK cells that are CD27- CD11b+ [%] CD27_neg_CD11b_pos 63507

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic NK cells that are pre-mNK (B220+ CD11c+) [%] pre_mNK_of_NK 63508

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are pre-mNK (B220+ CD11c+) [%] pre_mNK_of_tot 63509

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are NK T cells (TCRb+ CD1d+) [%] NKT_cells 63510

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic NK T cells that are CD4+ CD8- [%] CD4_pos_CD8_neg_of_NKT 63511

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD4+ NK T cells [%] CD4_pos_CD8_neg_NKT_of_tot 63512

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic NK T cells that are CD4- CD8- [%] CD4_neg_CD8_neg_of_NKT 63513

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD4- CD8- NK T cells [%] CD4_neg_CD8_neg_NKT_of_tot 63514

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are T cells [%] T_cells 63515

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic T cells that are CD4+ CD8- [%] CD4_pos_CD8_neg_of_Tcells 63516

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD4+ T cells [%] CD4_pos_CD8_neg_of_tot 63517

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic T cells that are CD4- CD8+ [%] CD4_neg_CD8_pos_of_Tcells 63518

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD8+ T cells [%] CD4_neg_CD8_pos_of_tot 63519

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic T cells that are CD4- CD8- [%] CD4_neg_CD8_neg_of_Tcells 63520

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic lymphocytes that are CD4- CD8- T cells [%] CD4_neg_CD8_neg_of_tot 63521

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

ratio of splenic CD4+ to CD8+ T cells [ratio] CD4_CD8_ratio 63522

CC w/par

76

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic leukocytes that are plasmacytoid dendritic cells [%] pDC 63523

CC w/par

74

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic leukocytes that are conventional dendritic cells [%] cDC 63524

CC w/par

74

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic conventional dendritic cells that are merocytic [%] mDC_of_cDC 63525

CC w/par

74

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic leukocytes that are merocytic dendritic cells [%] mDC_of_tot 63526

CC w/par

74

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic conventional dendritic cells that are cDC1 [%] cDC1_of_cDC 63527

CC w/par

74

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic leukocytes that are cDC1 conventional dendritic cells [%] cDC1_of_tot 63528

CC w/par

74

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic conventional dendritic cells that are cDC2 [%] cDC2_of_cDC 63529

CC w/par

74

both

5-8wks

N=2

2018

Lesage1

immune cell quantification

(none)

percentage of splenic leukocytes that are cDC2 conventional dendritic cells [%] cDC2_of_tot 63530

CC w/par

74

both

5-8wks

N=2

2018

Lesage2

immune cell quantification

(none)

total number of splenic lymphocytes (x 10⁶) [n] spleen_cells_tot 131924

CC w/par

76

both

5-8wks

N=2

2024

Lesage2

immune cell quantification

(none)

number of B cells in spleen (x 10⁶) [n] B_cells_tot 131925

CC w/par

76

both

5-8wks

N=2

2024

Lesage2

immune cell quantification

(none)

percentage of splenic lymphocytes that are B cells (CD3-CD49b-B220+CD19+) [%] B_cells_pct 131926

CC w/par

76

both

5-8wks

N=2

2024

Mahler1

organ weights

(none)

spleen to body weight ratio, first Principal Component [ratio] SplBW 12101

QTL population

both

6wks

N=102

2002

Mills1

apoptosis assessment

(none)

early apoptotic splenocytes [%] early_apoptotic 25205 6mo 12mo 20mo

inbred

30

both

N=3

2008

Mills1

apoptosis assessment

(none)

late apoptotic splenocytes [%] late_apoptotic 25211 6mo 12mo 20mo

inbred

30

both

N=3

2008

Mills1

apoptosis assessment

(none)

all apoptotic splenocytes [%] all_apoptotic 25217 6mo 12mo 20mo

inbred

30

both

N=3

2008

Reed2

organ weights

(none)

spleen weight [g] spleen_wt 53156

B6.129 and 129.B6 consomic w/par

9

both

26wks

N=17

2015

Rodriguez1

in vitro assay

(none)

spleen and liver murine cytomegalovirus genome levels (normalized to endogenous b-actin) [ratio] CMV_LEVELS 24101

QTL population

both

8-12wks

N=92

2009

Schoonjans1

organ weights

high-fat diet

spleen weight [g] spleen_wt 112857 CD HFD

BXD w/par

35

m

29wks

N=5

2021

Svenson7

body weight

(none)

spleen weight [g] spleen_wt 121575 chow hfhs

DO population

both

26-30wks

N=167

2020

Williams1

immune cell quantification

(none)

CD4 Treg cells (CD25+ CD44^int; as percentage of lymphocytes) [%] Treg 42901

inbred

5

f

8wks

N=3

2012

Williams1

immune cell quantification

(none)

CD4 Treg cells (CD25+ CD44^int; as percentage of CD4 T cells) [%] Treg_adj 42902

inbred

5

f

8wks

N=3

2012

Williams1

immune cell quantification

(none)

memory-effector CD4 T cells (CD25^- CD44^hi; as percentage of lymphocytes) [%] memoryT 42903

inbred

5

f

8wks

N=3

2012

Williams1

immune cell quantification

(none)

memory-effector CD4 T cells (CD25^- CD44^hi; as percentage of CD4 T cells) [%] memoryT_adj 42904

inbred

5

f

8wks

N=3

2012

Williams1

immune cell quantification

(none)

naive CD4 T cells (CD25^- CD44^lo; as percentage of lymphocytes) [%] naiveT 42905

inbred

5

f

8wks

N=3

2012

Williams1

immune cell quantification

(none)

naive CD4 T cells (CD25^- CD44^lo; as percentage of CD4 T cells) [%] naiveT_adj 42906

inbred

5

f

8wks

N=3

2012

Wiltshire4

immune cell quantification

BEZ235

B cells, percent viability [%] Bcells_BEZ 52401 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

34

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

BEZ235

T cells, percent viability [%] Tcells_BEZ 52407 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

34

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

BEZ235

monocytes, percent viability [%] monocytes_BEZ 52413 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

34

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

doxorubicin

B cells, percent viability [%] Bcells_Dox 52421 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

35

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

doxorubicin

T cells, percent viability [%] Tcells_Dox 52427 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

35

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

doxorubicin

monocytes, percent viability [%] monocytes_Dox 52433 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

35

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

idarubicin

B cells, percent viability [%] Bcells_Ida 52441 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

35

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

idarubicin

T cells, percent viability [%] Tcells_Ida 52447 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

35

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

idarubicin

monocytes, percent viability [%] monocytes_Ida 52453 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

35

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

selumetinib

B cells, percent viability [%] Bcells_Sel 52461 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

34

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

selumetinib

T cells, percent viability [%] Tcells_Sel 52467 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

34

m

10wks

N=4

2015

Wiltshire4

immune cell quantification

selumetinib

monocytes, percent viability [%] monocytes_Sel 52473 dose [µM]: control 0.046 0.137 1.235 11.1 100

inbred w/CC7

34

m

10wks

N=4

2015

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