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Schoonjans1:
Changes in bile acid pool size and composition in plasma, feces and liver; body and organ weights; and blood glucose levels in male mice of 34 BXD recombinant inbred strains and two parental strains fed chow or high-fat diet (2022)
Li H, Perino A, Huang Q, Von Alvensleben GVG, Banaei-Esfahani A, Velazquez-Villegas LA, Gariani K, Korbelius M, Bou Sleiman M, Imbach J, Sun Y, Li X, Bachmann A, Goeminne LJE, Gallart-Ayala H, Williams EG, Ivanisevic J, Auwerx J, Schoonjans K. Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis.
Cell Metab. pii: S1550-4131(22)00358-8. doi: 10.1016/j.cmet.2022.08.015.
PubMed 36099916
École Polytechnique Fédérale de Lausanne; Kristian Gerhard Jebsen Foundation; European Research Council; Swiss National Science Foundation
Project type
Phenotype strain survey data set
MPD identifiers
Schoonjans1 MPD:1049
Data changelog
No updates/corrections.
Initial release date: 09/2022.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Male BXD mice were fed either a standard chow diet (CD) or a high-fat diet (HFD) from 8 to 29 weeks of age. The effects of diet on the accumulation of 27 different bile acids (BAs) in plasma, feces and liver were assessed by liquid chromatography - high-resolution mass spectrometry (LC-HRMS). The effects of HFD diet were measured for body weight at 8 wks, at 20 wks (at 9 am and immediately after the glucose kinetic test), and prior to sacrifice. Postprandial plasma glucose (following Ensure Plus oral gavage) and plasma BA levels were both determined at 0, 30, 60 min at 20 wks for CD and HFD fed mice. BAs in feces were measured at 24 wks, and in liver at 29 wks. Organs were weighed at sacrifice (29 wks).
Experimental groups in this study: • Chow diet (CD)• High fat diet (HFD)
Procedures conducted:
• body weight
At 8, 20 and 29 wks of age.
• glucose tolerance
Plasma glucose levels at 0, 30, 60 min post oral gavage of Ensure Plus, overday fast.
