MPD: Data set: Svenson7

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Svenson7: Effects of a high fat high sucrose diet on physiological traits in Diversity Outbred (DO) mice. (2020) [Pending]

Svenson KL, Gatti DM, Churchill GA With: Simecek P, Somes L, Jeffrey CT, Vincent MJ, Choi K, Chen X

Svenson7 downloads
• Download Svenson7 project data set animal data, as uploaded
• Download Svenson7 animal data matrix with factor-related expansion applied as necessary
• Download Svenson7 strain means, SD, N, etc. one row per strain/sex/measure
• Download Svenson7 supplementary file, svenson_hfd_DO_phenotype_description_2021.csv Phenotype descriptions
• Download Svenson7 supplementary file, Svenson_HFD_DO_RNA_counts.csv
• Download Svenson7 supplementary file, Svenson_HFD_DO_protein.csv

Ontology terms mapped to Svenson7 measures:

Investigators	Karen L Svenson The Jackson Laboratory, Bar Harbor, ME Daniel M Gatti The Jackson Laboratory, Bar Harbor, ME Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Simecek P, Somes L, Jeffrey CT, Vincent MJ, Choi K, Chen X
Contact	Karen L Svenson karen.svenson@jax.org Lab web site
Project type	Phenotype strain survey data set
MPD identifiers	Svenson7 MPD:1021
Data changelog	This project has not yet been released.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

The effects of diet and sex on DO mice were investigated. DO mice of both sexes were fed either a regular chow diet or a high fat, high sucrose (HFHS, 45% fat, 40% carbohydrate, and 15% protein) diet. Various physiological traits were measured throughout the study, such as effects on body/organ weight, blood glucose levels, urinalysis and clinical chemistry. Genotypes are available at DODB (search for Svenson).

Experimental groups in this study:
• Chow • High fat high sucrose diet (HFHS)

Procedures conducted:

• body weight		Body weight from 3-30 wks of age. Principal components.
• metabolic panel		Clinical chemistry at 8 and 19 wks of age. 4h fast. Clinical chemistry at 17 wks of age. No fast.
• lipid profile		Cholesterol, fatty acids, triglyceride at 8 and 19 wks of age. 4h fast.
• complete blood count		Hematology at 10 and 22 wks of age.
• urinalysis		Glucose, creatinine, microalbumin, albumin-creatinine ratio at 11 and 20 wks of age.
• body size and weight		Body length at 12 and 21 wks of age.
• DXA		Body mass, lean mass, fat mass, bone mineral density at 12 and 21 wks of age.
• ECG		Heart rate and wave intervals at 13 wks. Conscious.
• MRI		Lean and fat tissue mass, water mass at 16 wks of age.
• glucose tolerance		0-180 min after 20% glucose i.p. at 23-24 wks of age. 15h fast.
• organ weights		Heart, kidney, spleen at 26-30 wks.

Mice: DO population 99 strains ♀♂ age 3-30 wks 2 experimental groups

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Svenson7:39	Svenson7	body weight	(none)	body weight at 3 wks of age [g] bw_3wks 121284 chow hfhs	DO population	both	3wks	N=62

Svenson7:41	Svenson7	body weight	(none)	body weight at 4 wks of age [g] bw_4wks 121286 chow hfhs	DO population	both	4wks	N=191

Svenson7:43	Svenson7	body weight	(none)	body weight at 5 wks of age [g] bw_5wks 121288 chow hfhs	DO population	both	5wks	N=198

Svenson7:45	Svenson7	body weight	(none)	body weight at 6 wks of age [g] bw_6wks 121290 chow hfhs	DO population	both	6wks	N=198

Svenson7:47	Svenson7	body weight	(none)	body weight at 7 wks of age [g] bw_7wks 121292 chow hfhs	DO population	both	7wks	N=197

Svenson7:49	Svenson7	body weight	(none)	body weight at 8 wks of age [g] bw_8wks 121294 chow hfhs	DO population	both	8wks	N=197

Svenson7:51	Svenson7	body weight	(none)	body weight at 10 wks of age [g] bw_10wks 121296 chow hfhs	DO population	both	10wks	N=209

Svenson7:53	Svenson7	body weight	(none)	body weight at 14 wks of age [g] bw_14wks 121298 chow hfhs	DO population	both	14wks	N=208

Svenson7:55	Svenson7	body weight	(none)	body weight at 18 wks of age [g] bw_18wks 121300 chow hfhs	DO population	both	18wks	N=207

Svenson7:57	Svenson7	body weight	(none)	body weight at 22 wks of age [g] bw_22wks 121302 chow hfhs	DO population	both	22wks	N=194

Svenson7:59	Svenson7	body weight	(none)	body weight at 26 wks of age [g] bw_26wks 121304 chow hfhs	DO population	both	26wks	N=162

Svenson7:61	Svenson7	body weight	(none)	body weight at 30 wks of age [g] bw_30wks 121306 chow hfhs	DO population	both	30wks	N=24

Svenson7:63	Svenson7	body weight	(none)	body weight, principal component 1, at 10 to 20 wks of age [g] bw_pc1 121308 chow hfhs	DO population	both	10-20wks	N=208

Svenson7:65	Svenson7	body weight	(none)	body weight, principal component 2, at 10 to 20 wks of age [g] bw_pc2 121310 chow hfhs	DO population	both	10-20wks	N=208

Svenson7:67	Svenson7	metabolic panel	(none)	total bilirubin (plasma TBIL), 4h fast, at 8 wks of age [mg/dL] tbil_8wks 121312 chow hfhs	DO population	both	8wks	N=47

Svenson7:69	Svenson7	metabolic panel	(none)	total bilirubin (plasma TBIL), 4h fast, at 19 wks of age [mg/dL] tbil_19wks 121314 chow hfhs	DO population	both	19wks	N=36

Svenson7:71	Svenson7	metabolic panel	(none)	calcium (plasma Ca), 4h fast, at 8 wks of age [mg/dL] calcium_8wks 121316 chow hfhs	DO population	both	8wks	N=161

Svenson7:73	Svenson7	metabolic panel	(none)	calcium (plasma Ca), 4h fast, at 19 wks of age [mg/dL] calcium_19wks 121318 chow hfhs	DO population	both	19wks	N=192

Svenson7:75	Svenson7	metabolic panel	(none)	phosphorus (plasma P), 4h fast, at 8 wks of age [mg/dL] phosphorus_8wks 121320 chow hfhs	DO population	both	8wks	N=161

Svenson7:77	Svenson7	metabolic panel	(none)	phosphorus (plasma P), 4h fast, at 19 wks of age [mg/dL] phosphorus_19wks 121322 chow hfhs	DO population	both	19wks	N=192

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Svenson7: Effects of a high fat high sucrose diet on physiological traits in Diversity Outbred (DO) mice. (2020) [Pending]

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