MPD: Data set: Harrill1

Church RJ, Wu H, Mosedale M, Sumner SJ, Pathmasiri W, Kurtz CL, Pletcher MT, Eaddy JS, Pandher K, Singer M, Batheja A, Watkins PB(7), Adkins K, Harrill AH(8). A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis. Toxicol Sci. 2014 Aug 1;140(2):481-92. doi: 10.1093/toxsci/kfu094. Epub 2014 May 20. PubMed 24848797 FullText

Harrill1 downloads
• Download Harrill1 project data set animal data, as uploaded
• Download Harrill1 animal data matrix with factor-related expansion applied as necessary
• Download Harrill1 strain means, SD, N, etc. one row per strain/sex/measure
• Harrill1 supplementary data

Ontology terms mapped to Harrill1 measures:

MA:0000141 spleen
MA:0000358 liver
MA:0002502 serum
MP:0000598 abnormal liver morphology
MP:0000607 abnormal hepatocyte morphology
MP:0001259 abnormal body weight
MP:0001573 abnormal circulating alanine transaminase level
MP:0004847 abnormal liver weight
MP:0004951 abnormal spleen weight
MP:0008872 abnormal physiological response to xenobiotic
MP:0012776 abnormal liver cholesterol level
MP:0012778 abnormal liver triglyceride level
VT:0000598 liver morphology trait
VT:0000607 hepatocyte morphology trait
VT:0000609 liver physiology trait
VT:0000689 spleen morphology trait
VT:0001259 body mass
VT:0001547 lipid amount
VT:0001573 blood alanine transaminase amount
VT:0003402 liver mass
VT:0004951 spleen mass
VT:0010487 response to xenobiotic stimulus trait

Investigators	Alison Harrill University of Arkansas for Medical Sciences, Little Rock, AR
Contact	Alison Harrill AHHarrill@uams.edu Lab web site
Acknowledgements	Funding provided by Pfizer, Inc., AstraZeneca, and Lilly; International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI)
Project type	Phenotype strain survey data set
MPD identifiers	Harrill1 MPD:395
Data changelog	No updates/corrections. Initial release date: 06/2014.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

A treatment/control study of isoniazid. Treated group received Rx daily for 3 days. Control group received vehicle only for 3 days. See protocol timeline for details. All measurements taken on day 4 unless otherwise stated.

Procedures conducted:

• body weight		Body weight. Isoniazid-treated vs. control.
• organ weights		Body, liver, kidney weights. Isoniazid-treated vs. control.
• metabolic panel		Alanine transaminase. Isoniazid-treated vs. control.
• lipid profile		Cholesterol, triglycerides. Hepatic lipids. Isoniazid-treated vs. control.
• histopathology		Liver pathology scores. Isoniazid-treated vs. control.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Harrill1:1	Harrill1	body weight	(none)	body weight day 1 [g] bw_d1 39501 control group treatment group	inbred	34	f	8-10wks	N=4

Harrill1:3	Harrill1	body weight	isoniazid	body weight day 4 [g] bw_d4 39503 control isoniazid	inbred	33	f	8-10wks	N=4

Harrill1:5	Harrill1	organ weights	isoniazid	liver weight [g] liver 39505 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:7	Harrill1	organ weights	isoniazid	liver weight as percentage of body weight [%] pct_liver 39507 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:11	Harrill1	organ weights	isoniazid	spleen weight [g] spleen 39511 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:13	Harrill1	organ weights	isoniazid	spleen weight as percentage of body weight [%] pct_spleen 39513 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:21	Harrill1	metabolic panel	isoniazid	alanine transaminase (serum ALT) [IU/L] ALT 39521 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:26	Harrill1	lipid profile	isoniazid	hepatic cholesterol (CHOL) [mg/dL] liver_CHOL 39526 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:31	Harrill1	lipid profile	isoniazid	hepatic triglycerides (TG) [mg/dL] liver_TG 39531 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:41	Harrill1	histopathology	isoniazid	lymphohistiocytic, portal, multifocal infiltrate [score] lymphohistio_portal 39541 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:46	Harrill1	histopathology	isoniazid	hepatocytic cytoplasmic, microvesiculation, multifocal [score] microvesic_multi 39546 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:51	Harrill1	histopathology	isoniazid	hepatocytic cytoplasmic, microvesiculation, diffuse [score] microvesic_dif 39551 control isoniazid	inbred	34	f	8-10wks	N=4

Harrill1:56	Harrill1	histopathology	isoniazid	hepatocytic hypertrophy, panlobular, diffuse [score] hypertro_pan 39556 control isoniazid	inbred	34	f	8-10wks	N=4

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Harrill1: Drug study: Clinico-pathological survey of the liver and adverse reactions in response to isoniazid treatment in females of 34 inbred strains of mice (2011)

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Harrill1: Drug study: Clinico-pathological survey of the liver and adverse reactions in response to isoniazid treatment in females of 34 inbred strains of mice (2011)

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These results could be incomplete or invalid. Staff have been notified.