MPD: Data set: Cheverud1

Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF. Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. Diabetes. 2004 Oct;53(10):2700-8. PubMed 15448104

Hrbek T, de Brito RA, Wang B, Pletscher LS, Cheverud JM. Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains. Mamm Genome. 2006 May;17(5):417-29. PubMed 16688532

Notes
Genotypic data (Mit markers) for QTL analysis are available in the supplemental file.

Static graphs are available for the glucose clearance tests.

Cheverud1 downloads
• Download Cheverud1 project data set animal data, as uploaded
• Download Cheverud1 animal data matrix with factor-related expansion applied as necessary
• Download Cheverud1 strain means, SD, N, etc. one row per strain/sex/measure
• Cheverud1 supplementary data

Ontology terms mapped to Cheverud1 measures:

MA:0000059 blood
MA:0000072 heart
MA:0000141 spleen
MA:0000358 liver
MA:0000368 kidney
MA:0000472 abdominal fat pad
MA:0002481 fat pad
MA:0002502 serum
MA:0002547 gonadal fat pad
MA:0002548 inguinal fat pad
MA:0002549 retroperitoneal fat pad
MP:0000180 abnormal circulating cholesterol level
MP:0000188 abnormal circulating glucose level
MP:0001259 abnormal body weight
MP:0001553 abnormal circulating free fatty acids level
MP:0001560 abnormal circulating insulin level
MP:0002089 abnormal postnatal growth/weight/body size
MP:0002707 abnormal kidney weight
MP:0004847 abnormal liver weight
MP:0004857 abnormal heart weight
MP:0004951 abnormal spleen weight
MP:0005291 abnormal glucose tolerance
MP:0005335 abnormal gonadal fat pad morphology
MP:0005336 abnormal inguinal fat pad morphology
MP:0005667 abnormal circulating leptin level
MP:0008902 abnormal renal fat pad morphology
MP:0008903 abnormal mesenteric fat pad morphology
MP:0011969 abnormal circulating triglyceride level
MP:0020130 abnormal total fat pad weight
VT:0000180 blood cholesterol amount
VT:0000188 blood glucose amount
VT:0000689 spleen morphology trait
VT:0001259 body mass
VT:0001553 blood free fatty acid amount
VT:0001560 blood insulin amount
VT:0001731 postnatal growth trait
VT:0002644 blood triglyceride amount
VT:0002707 kidney mass
VT:0003402 liver mass
VT:0004951 spleen mass
VT:0005335 gonadal fat pad morphology trait
VT:0005336 inguinal fat pad morphology trait
VT:0005452 adipose amount
VT:0005667 blood leptin amount
VT:0007028 heart mass
VT:0015004 mesenteric fat pad morphology trait
VT:0015006 renal fat pad morphology trait
VT:0015008 total fat pad mass
VT:0015088 glucose metabolism trait

Investigators	James M Cheverud Washington University School of Medicine, St. Louis, MO
Participants	Hrbek T, de Brito RA, Wang B, Pletscher LS, Ehrich TH, Kenney JP, Semenkovich CF
Contact	James M Cheverud cheverud@pcg.wustl.edu Lab web site
Acknowledgements	Funding provided by NIH DK55736, DK52514, HL58427, RR15116, DK56431, DK20579
Project type	Phenotype strain survey data set
MPD identifiers	Cheverud1 MPD:178
Data changelog	No updates/corrections. Initial release date: 11/2008.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

There were 2 cohorts: 1) controls on standard diet; and 2) mice fed a high fat diet (42% calories from fat).

Experimental groups in this study:
• None • None

Procedures conducted:

• body weight		Body weight and growth curve from age 1wk to 22wks (pre-wean, post-wean, adult). High-fat diet (17wks) vs. control.
• fat pad weights		High-fat diet (17wks) vs. control.
• glucose tolerance		High-fat diet (17wks) vs. control. 0 to 120 min after 10% glucose i.p. 4h fast.
• lipid profile		Cholesterol, triglycerides, free fatty acids. High-fat diet (17wks) vs. control. 4h fast, serum.
• organ weights		Heart, liver, kidney, spleen weights after high-fat diet (17wks) vs. control.
• hormone quantification		Insulin, leptin.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Cheverud1:1	Cheverud1	body weight	(none)	body weight on control diet [g] bw_ctrl 17801 age (wks): 4 5 6 7 9 11 15 19 23	LGXSM w/par	17	both	12-16wks	N=8

Cheverud1:10	Cheverud1	body weight	(none)	body weight at necropsy (local parameter) [g] bwnec_ctrl 17812	LGXSM w/par	16	both	20-30wks	N=8

Cheverud1:11	Cheverud1	body weight	(none)	pre-weaning (1-3 wks) growth rate [g/wk] gr_neonatal 17814 control group high-fat diet group	LGXSM w/par	18	both	1-3wks	N=9

Cheverud1:13	Cheverud1	body weight	high-fat diet	growth rate, age 4 to 10wks [g/wk] gr_juvenile 17815 control diet high-fat diet	LGXSM w/par	18	both	12-16wks	N=8

Cheverud1:15	Cheverud1	body weight	high-fat diet	growth rate, age 11 to 20 wks [g/wk] gr_adult 17816 control diet high-fat diet	LGXSM w/par	17	both	12-16wks	N=8

Cheverud1:17	Cheverud1	organ weights	high-fat diet	kidney weight (both) as percentage of body weight [%] kidneywt_adj 17820 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:19	Cheverud1	organ weights	high-fat diet	heart weight as percentage of body weight [%] heartwt_adj 17821 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:21	Cheverud1	organ weights	high-fat diet	spleen weight as percentage of body weight [%] spleenwt_adj 17822 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:23	Cheverud1	organ weights	high-fat diet	liver weight as percentage of body weight [%] liverwt_adj 17823 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:25	Cheverud1	fat pad weights	high-fat diet	gonadal fat pad weight [g] gonadal_fatwt 17824 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:27	Cheverud1	fat pad weights	high-fat diet	perirenal fat pad weight [g] perirenal_fatwt 17825 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:29	Cheverud1	fat pad weights	high-fat diet	mesenteric fat pad weight [g] mesenteric_fatwt 17826 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:31	Cheverud1	fat pad weights	high-fat diet	inguinal fat pad weight [g] inguinal_fatwt 17827 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:33	Cheverud1	fat pad weights	high-fat diet	total fat pad weight [g] total_fatwt 17828 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:35	Cheverud1	fat pad weights	high-fat diet	gonadal fat pad weight as percentage of body weight [%] gonadal_pctfat 17829 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:37	Cheverud1	fat pad weights	high-fat diet	perirenal fat pad weight as percentage of body weight [%] perirenal_pctfat 17830 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:39	Cheverud1	fat pad weights	high-fat diet	mesenteric fat pad weight as percentage of body weight [%] mesenteric_pctfat 17831 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:41	Cheverud1	fat pad weights	high-fat diet	inguinal fat pad weight as percentage of body weight [%] inguinal_pctfat 17832 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:43	Cheverud1	fat pad weights	high-fat diet	total fat pad weight as percentage of body weight [%] total_pctfat 17833 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:45	Cheverud1	hormone quantification	high-fat diet	insulin (serum) [ng/mL] insulin 17840 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:47	Cheverud1	hormone quantification	high-fat diet	leptin (serum) [pg/mL] leptin 17841 control diet high-fat diet	LGXSM w/par	10	both	20-30wks	N=6

Cheverud1:49	Cheverud1	lipid profile	high-fat diet	total cholesterol (serum CHOL) [mg/dL] CHOL 17842 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:51	Cheverud1	lipid profile	high-fat diet	free fatty acid (serum FFA) [mg/dL] FFA 17843 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:53	Cheverud1	lipid profile	high-fat diet	triglycerides (serum TG, 4h fast) [mg/dL] TG 17844 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:55	Cheverud1	glucose tolerance	high-fat diet	glucose levels, area under curve, glucose tolerance test (serum GLU, 10% glucose i.p., 4h fast) [AUC] GLU_clear10 17845 control diet high-fat diet	LGXSM w/par	18	both	10wks	N=8

Cheverud1:57	Cheverud1	glucose tolerance	high-fat diet	glucose levels, area under curve, glucose tolerance test (serum GLU, 10% glucose i.p., 4h fast) [AUC] GLU_clear20 17846 control diet high-fat diet	LGXSM w/par	17	both	20wks	N=8

Cheverud1:59	Cheverud1	body weight	high-fat diet	body weight on high-fat diet [g] bw_hifat 17851 age (wks): 4 5 6 7 9 11 15 19 23	LGXSM w/par	18	both	12-16wks	N=8

Cheverud1:68	Cheverud1	body weight	(none)	body weight at necropsy (local parameter) [g] bwnec_hifat 17862	LGXSM w/par	17	both	20-30wks	N=8

Cheverud1:69	Cheverud1	colony observation	(none)	age at necropsy (local parameter) [wks] nec_age 17899	LGXSM w/par	17	both		N=16

Cheverud1: Diet-induced obesity and diabetes in 19 LGXSM recombinant inbred strains of mice (2004)

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