|
liverwt_ctrl liver weight 24h after treatment
, control
19401
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
5 |
4 |
4 |
4 |
4 |
4 |
5 |
4 |
4 |
4 |
4 |
4 |
4 |
3 |
4 |
5 |
4 |
4 |
4 |
4 |
5 |
4 |
4 |
4 |
4 |
4 |
4 |
5 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
5 |
4 |
|
liverwt_Rx100_24h liver weight 24h after treatment
, dose: 100 mg/kg
19403
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
4 |
|
|
|
|
|
2 |
|
4 |
|
|
|
3 |
|
|
4 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
liver_necrosis_ctrl necrosis
, control
19404
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
3 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
|
liver_necrosis_Rx100 necrosis
, dose: 100 mg/kg
19405
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
4 |
|
|
|
|
|
2 |
|
4 |
|
|
|
|
|
|
4 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
ALT_ctrl alanine transaminase (serum ALT)
19406
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
3 |
2 |
2 |
4 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
2 |
|
ALT_Rx100_4h alanine transaminase (serum ALT), t=4h
19407
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
4 |
|
|
|
|
|
2 |
|
4 |
|
|
|
3 |
|
|
4 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
ALT_Rx100_12h alanine transaminase (serum ALT), t=12h
19408
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
4 |
|
|
|
|
|
2 |
|
4 |
|
|
|
3 |
|
|
4 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
ALT_Rx100_24h alanine transaminase (serum ALT), t=24h
19409
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
3 |
|
|
|
|
|
2 |
|
4 |
|
|
|
3 |
|
|
4 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
AST_ctrl aspartate transaminase (serum AST)
, control
19410
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
1 |
1 |
2 |
2 |
3 |
2 |
|
AST_Rx100 aspartate transaminase (serum AST)
, dose: 100 mg/kg
19411
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
3 |
|
|
|
|
|
2 |
|
4 |
|
|
|
3 |
|
|
4 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
BUN_ctrl blood urea nitrogen (serum BUN)
, control
19412
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
2 |
2 |
2 |
2 |
2 |
1 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
3 |
1 |
1 |
2 |
2 |
1 |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
|
1 |
2 |
2 |
2 |
2 |
|
BUN_Rx100 blood urea nitrogen (serum BUN)
, dose: 100 mg/kg
19413
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
3 |
|
|
|
|
|
2 |
|
4 |
|
|
|
3 |
|
|
4 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
GSH_ctrl reduced glutathione (GSH)
, control
19414
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
1 |
2 |
2 |
|
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
|
2 |
2 |
2 |
2 |
2 |
2 |
1 |
1 |
|
GSSG_ctrl oxidized glutathione (GSSG)
, control
19416
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
1 |
2 |
2 |
|
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
|
2 |
2 |
2 |
2 |
2 |
2 |
1 |
1 |
|
GSH_total_ctrl total glutathione (GSH plus GSSG)
, control
19418
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
1 |
2 |
2 |
|
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
|
2 |
2 |
2 |
2 |
2 |
2 |
1 |
1 |
|
GSHratio_ctrl ratio of reduced (GSH) to oxidized (GSSG) glutathione
, control
19420
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
1 |
2 |
2 |
|
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
|
2 |
2 |
2 |
2 |
2 |
2 |
1 |
1 |
|
liverwt_Rx200_24h liver weight 24h after treatment
, dose: 200 mg/kg
19433
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
3 |
4 |
|
|
|
|
|
4 |
|
4 |
|
|
|
3 |
|
|
3 |
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
liver_necrosis_Rx200 necrosis
, dose: 200 mg/kg
19435
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
4 |
|
|
|
|
|
4 |
|
4 |
|
|
|
|
|
|
4 |
|
|
|
|
|
|
|
|
|
|
4 |
|
|
|
AST_Rx200 aspartate transaminase (serum AST)
, dose: 200 mg/kg
19441
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
3 |
|
|
|
|
|
3 |
|
4 |
|
|
|
3 |
|
|
4 |
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
BUN_Rx200 blood urea nitrogen (serum BUN)
, dose: 200 mg/kg
19443
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
|
|
|
4 |
|
|
|
4 |
3 |
|
|
|
|
|
3 |
|
4 |
|
|
|
3 |
|
|
4 |
|
|
|
|
|
|
|
|
|
|
3 |
|
|
|
liverwt_Rx300_24h liver weight 24h after treatment
, dose: 300 mg/kg
19463
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
4 |
4 |
6 |
3 |
4 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
3 |
4 |
4 |
3 |
6 |
4 |
4 |
4 |
3 |
4 |
3 |
4 |
4 |
4 |
4 |
3 |
3 |
4 |
4 |
4 |
4 |
4 |
4 |
3 |
4 |
|
liver_necrosis_Rx300 necrosis
, dose: 300 mg/kg
19465
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
4 |
4 |
7 |
3 |
4 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
2 |
4 |
4 |
3 |
6 |
4 |
4 |
4 |
3 |
4 |
3 |
3 |
4 |
4 |
4 |
3 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
3 |
3 |
|
AST_Rx300 aspartate transaminase (serum AST)
, dose: 300 mg/kg
19471
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
4 |
4 |
7 |
3 |
4 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
3 |
2 |
4 |
3 |
6 |
3 |
4 |
3 |
3 |
4 |
3 |
4 |
4 |
4 |
4 |
3 |
4 |
3 |
3 |
4 |
3 |
4 |
4 |
3 |
4 |
|
BUN_Rx300 blood urea nitrogen (serum BUN)
, dose: 300 mg/kg
19473
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
4 |
3 |
7 |
3 |
4 |
4 |
3 |
3 |
4 |
4 |
4 |
4 |
3 |
1 |
4 |
2 |
6 |
2 |
4 |
3 |
3 |
4 |
2 |
4 |
4 |
4 |
3 |
3 |
4 |
2 |
2 |
3 |
3 |
3 |
4 |
2 |
4 |
|
GSH_Rx300 reduced glutathione (GSH)
, post-Rx 300mg/kg
19475
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
5 |
4 |
4 |
4 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
3 |
4 |
3 |
4 |
4 |
3 |
3 |
4 |
3 |
4 |
4 |
4 |
5 |
5 |
4 |
|
4 |
4 |
4 |
3 |
4 |
3 |
4 |
1 |
|
GSSG_Rx300 oxidized glutathione (GSSG)
, post-Rx 300mg/kg
19477
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
5 |
4 |
4 |
4 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
3 |
4 |
3 |
4 |
4 |
3 |
3 |
4 |
3 |
4 |
4 |
4 |
5 |
5 |
4 |
|
4 |
4 |
4 |
3 |
4 |
3 |
4 |
1 |
|
GSH_total_Rx300 total glutathione (GSH plus GSSG)
, post-Rx 300 mg/kg
19479
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
5 |
4 |
4 |
4 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
3 |
4 |
3 |
4 |
4 |
3 |
3 |
4 |
3 |
4 |
4 |
4 |
5 |
5 |
4 |
|
4 |
4 |
4 |
3 |
4 |
3 |
4 |
1 |
|
GSHratio_Rx300 ratio of reduced (GSH) to oxidized (GSSG) glutathione
, post-Rx 300mg/kg
19481
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
5 |
4 |
4 |
4 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
4 |
3 |
3 |
4 |
3 |
4 |
4 |
3 |
3 |
4 |
3 |
4 |
4 |
4 |
5 |
5 |
4 |
|
4 |
4 |
4 |
3 |
4 |
3 |
4 |
1 |
|
catalase_ctrl catalase
, control
19482
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
3 |
2 |
1 |
2 |
2 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
3 |
2 |
|
CYP1A2_ctrl cytochrome P450 1A2 isoform
, control
19483
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
2 |
2 |
2 |
|
2 |
1 |
2 |
1 |
2 |
2 |
3 |
2 |
2 |
2 |
1 |
2 |
2 |
3 |
2 |
1 |
2 |
1 |
2 |
2 |
1 |
3 |
2 |
|
CYP2E1_ctrl cytochrome P450 2E1 isoform
, control
19484
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
2 |
2 |
2 |
1 |
2 |
2 |
1 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
1 |
2 |
2 |
3 |
1 |
2 |
2 |
1 |
2 |
2 |
3 |
2 |
2 |
2 |
1 |
2 |
2 |
1 |
3 |
2 |
|
GSTpi_ctrl glutathione transferase
, control
19486
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
3 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
2 |
1 |
2 |
2 |
3 |
2 |
2 |
1 |
1 |
2 |
2 |
2 |
3 |
2 |
|
catalase_Rx300 catalase
, post-Rx 300 mg/kg
19487
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
3 |
4 |
7 |
2 |
4 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
3 |
4 |
4 |
3 |
6 |
4 |
4 |
4 |
3 |
4 |
3 |
4 |
4 |
4 |
4 |
3 |
3 |
4 |
3 |
4 |
4 |
4 |
4 |
3 |
3 |
|
CYP1A2_Rx300 cytochrome P450 1A2 isoform
, post-Rx 300 mg/kg
19488
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
3 |
3 |
7 |
2 |
3 |
4 |
3 |
2 |
3 |
4 |
4 |
3 |
3 |
4 |
3 |
3 |
6 |
4 |
3 |
4 |
3 |
4 |
3 |
4 |
3 |
4 |
3 |
2 |
2 |
4 |
3 |
4 |
3 |
4 |
2 |
3 |
3 |
|
CYP2E1_Rx300 cytochrome P450 2E1 isoform
, post-Rx 300 mg/kg
19489
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
3 |
3 |
7 |
2 |
3 |
4 |
3 |
3 |
1 |
2 |
4 |
4 |
3 |
4 |
4 |
3 |
4 |
4 |
3 |
4 |
3 |
4 |
3 |
4 |
4 |
4 |
3 |
2 |
2 |
4 |
3 |
4 |
2 |
4 |
1 |
3 |
3 |
|
GSTpi_Rx300 glutathione transferase
, post-Rx 300 mg/kg
19491
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
3 |
3 |
7 |
2 |
4 |
4 |
3 |
4 |
4 |
4 |
4 |
4 |
3 |
4 |
4 |
3 |
6 |
4 |
1 |
4 |
3 |
4 |
3 |
4 |
4 |
4 |
4 |
3 |
2 |
4 |
3 |
4 |
4 |
4 |
4 |
3 |
3 |
|
age age at testing (local parameter)
19498
|
(F) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(M) |
14 |
12 |
27 |
26 |
12 |
12 |
12 |
26 |
24 |
12 |
15 |
12 |
12 |
29 |
26 |
12 |
31 |
18 |
12 |
15 |
33 |
12 |
12 |
24 |
12 |
13 |
15 |
12 |
12 |
12 |
12 |
12 |
12 |
15 |
24 |
15 |
12 |
|