Project measure / variable:   Threadgill1   BUN_Rx300

ID, description, units MPD:19473   BUN_Rx300   blood urea nitrogen (serum BUN)   [mg/dL]  dose: 300 mg/kg  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   37 strains     sex: m     age: 8-17wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Threadgill1 - blood urea nitrogen (serum BUN) dose: 300 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested37 strains
Mean of the strain means24.6   mg/dL
Median of the strain means20.3   mg/dL
SD of the strain means± 13.5
Coefficient of variation (CV)0.548
Min–max range of strain means12.0   –   75.3   mg/dL
Mean sample size per strain3.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 21825.8929 623.5969 1.7931 0.0147
Residuals 89 30952.1071 347.7765


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 33.2 23.0   4 11.5 0.691 9.0, 61.0 0.64
A/J m 14.0 7.94   3 4.58 0.567 8.0, 23.0 -0.79
AKR/J m 29.9 22.7   7 8.59 0.761 13.0, 67.0 0.4
B6C3F1/J m 48.3 37.1   3 21.4 0.767 19.0, 90.0 1.76
BALB/cByJ m 25.5 2.52   4 1.26 0.0987 23.0, 29.0 0.07
BTBR T+ Itpr3tf/J m 17.8 3.86   4 1.93 0.218 14.0, 23.0 -0.5
BUB/BnJ m 14.3 3.51   3 2.03 0.245 11.0, 18.0 -0.76
C3H/HeJ m 75.3 52.2   3 30.1 0.693 19.0, 122.0 3.77
C57BL/10J m 27.8 16.9   4 8.44 0.608 18.0, 53.0 0.24
C57BL/6J m 18.0 2.58   4 1.29 0.143 15.0, 21.0 -0.49
C57BLKS/J m 14.8 4.27   4 2.14 0.29 12.0, 21.0 -0.73
C57BR/cdJ m 31.5 27.7   4 13.9 0.881 15.0, 73.0 0.51
C57L/J m 16.3 4.04   3 2.33 0.247 14.0, 21.0 -0.61
CAST/EiJ m 17.0 0.0   1   0.0 0.0 17.0, 17.0 -0.56
CBA/J m 67.5 38.3   4 19.2 0.568 12.0, 100.0 3.19
CZECHII/EiJ m 14.0 0.0   2   0.0 0.0 14.0, 14.0 -0.79
DBA/2J m 34.0 42.8   6 17.5 1.26 11.0, 121.0 0.7
FVB/NJ m 26.5 2.12   2   1.5 0.08 25.0, 28.0 0.14
JF1/MsJ m 22.0 4.32   4 2.16 0.196 16.0, 26.0 -0.19
KK/HlJ m 25.7 7.51   3 4.33 0.292 18.0, 33.0 0.08
LP/J m 17.7 3.79   3 2.19 0.214 15.0, 22.0 -0.51
MA/MyJ m 18.8 3.86   4 1.93 0.206 15.0, 24.0 -0.43
MSM/MsJ m 21.0 1.41   2   1.0 0.0673 20.0, 22.0 -0.27
NOD/ShiLtJ m 13.8 1.71   4 0.854 0.124 12.0, 16.0 -0.8
NON/ShiLtJ m 19.8 1.71   4 0.854 0.0865 18.0, 22.0 -0.35
NZO/HlLtJ m 17.5 4.04   4 2.02 0.231 14.0, 23.0 -0.53
NZW/LacJ m 21.3 3.51   3 2.03 0.165 18.0, 25.0 -0.24
PERA/EiJ m 21.0 6.08   3 3.51 0.29 17.0, 28.0 -0.27
P/J m 19.8 7.14   4 3.57 0.361 14.0, 30.0 -0.35
PL/J m 17.0 2.83   2   2.0 0.166 15.0, 19.0 -0.56
PWD/PhJ m 27.0 1.41   2   1.0 0.0524 26.0, 28.0 0.18
RIIIS/J m 20.3 6.66   3 3.84 0.327 16.0, 28.0 -0.32
SEA/GnJ m 21.7 5.51   3 3.18 0.254 18.0, 28.0 -0.21
SJL/J m 20.0 3.46   3 2.0 0.173 16.0, 22.0 -0.34
SM/J m 28.2 8.1   4 4.05 0.287 19.0, 36.0 0.27
SWR/J m 12.0 5.66   2   4.0 0.471 8.0, 16.0 -0.93
WSB/EiJ m 19.0 4.62   4 2.31 0.243 15.0, 23.0 -0.41


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 33.25 9.3244 51.7774 14.7226
A/J m 14.0 10.7669 35.3935 0.0
AKR/J m 29.8571 7.0486 43.8625 15.8518
B6C3F1/J m 48.3333 10.7669 69.7269 26.9398
BALB/cByJ m 25.5 9.3244 44.0274 6.9726
BTBR T+ Itpr3tf/J m 17.75 9.3244 36.2774 0.0
BUB/BnJ m 14.3333 10.7669 35.7269 0.0
C3H/HeJ m 75.3333 10.7669 96.7269 53.9398
C57BL/10J m 27.75 9.3244 46.2774 9.2226
C57BL/6J m 18.0 9.3244 36.5274 0.0
C57BLKS/J m 14.75 9.3244 33.2774 0.0
C57BR/cdJ m 31.5 9.3244 50.0274 12.9726
C57L/J m 16.3333 10.7669 37.7269 0.0
CBA/J m 67.5 9.3244 86.0274 48.9726
CZECHII/EiJ m 14.0 13.1867 40.2016 0.0
DBA/2J m 34.0 7.6133 49.1275 18.8725
FVB/NJ m 26.5 13.1867 52.7016 0.2984
JF1/MsJ m 22.0 9.3244 40.5274 3.4726
KK/HlJ m 25.6667 10.7669 47.0602 4.2731
LP/J m 17.6667 10.7669 39.0602 0.0
MA/MyJ m 18.75 9.3244 37.2774 0.2226
MSM/MsJ m 21.0 13.1867 47.2016 0.0
NOD/ShiLtJ m 13.75 9.3244 32.2774 0.0
NON/ShiLtJ m 19.75 9.3244 38.2774 1.2226
NZO/HlLtJ m 17.5 9.3244 36.0274 0.0
NZW/LacJ m 21.3333 10.7669 42.7269 0.0
PERA/EiJ m 21.0 10.7669 42.3935 0.0
P/J m 19.75 9.3244 38.2774 1.2226
PL/J m 17.0 13.1867 43.2016 0.0
PWD/PhJ m 27.0 13.1867 53.2016 0.7984
RIIIS/J m 20.3333 10.7669 41.7269 0.0
SEA/GnJ m 21.6667 10.7669 43.0602 0.2731
SJL/J m 20.0 10.7669 41.3935 0.0
SM/J m 28.25 9.3244 46.7774 9.7226
SWR/J m 12.0 13.1867 38.2016 0.0
WSB/EiJ m 19.0 9.3244 37.5274 0.4726




  GWAS USING LINEAR MIXED MODELS