Project measure / variable:   Threadgill1   liver_necrosis_Rx200

ID, description, units MPD:19435   liver_necrosis_Rx200   necrosis   [%]  dose: 200 mg/kg  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   7 strains     sex: m     age: 8-17wks
Procedure histopathology
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  STRAIN COMPARISON PLOT
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Threadgill1 - necrosis dose: 200 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested7 strains
Mean of the strain means45.5   %
Median of the strain means45.5   %
SD of the strain means± 33.2
Coefficient of variation (CV)0.730
Min–max range of strain means0   –   96.2   %
Mean sample size per strain4.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 6 26530.0 4421.6667 10.6988 < 0.0001
Residuals 21 8679.0 413.2857


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6C3F1/J m 41.8 34.6   4 17.3 0.828 -0.11
C3H/HeJ m 0.0 0.0   4 0.0 0.0 -1.37
C57BL/10J m 63.8 14.7   4 7.33 0.23 48.0, 81.0 0.55
CBA/J m 96.2 7.5   4 3.75 0.0779 85.0, 100.0 1.53
DBA/2J m 45.5 11.4   4 5.69 0.25 31.0, 56.0 0.0
NOD/ShiLtJ m 8.75 12.7   4 6.37 1.46 -1.11
SM/J m 62.5 33.7   4 16.8 0.539 21.0, 100.0 0.51


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6C3F1/J m 41.75 10.1647 62.8887 20.6113
C3H/HeJ m 0.0 10.1647 21.1387 -21.1387
C57BL/10J m 63.75 10.1647 84.8887 42.6113
CBA/J m 96.25 10.1647 117.3887 75.1113
DBA/2J m 45.5 10.1647 66.6387 24.3613
NOD/ShiLtJ m 8.75 10.1647 29.8887 -12.3887
SM/J m 62.5 10.1647 83.6387 41.3613




  GWAS USING LINEAR MIXED MODELS