MPD: Data set: GMC03

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14. PubMed 32060626 FullText

GMC03 downloads
• Download GMC03 project data set animal data, as uploaded
• Download GMC03 animal data matrix with factor-related expansion applied as necessary
• Download GMC03 strain means, SD, N, etc. one row per strain/sex/measure
• GMC03 supplementary data

Ontology terms mapped to GMC03 measures:

MA:0000007 limb
MA:0000008 tail
MA:0000020 back of trunk
MA:0000155 coat hair
MA:0000163 vibrissa
MA:0000259 auricle
MA:0000261 eye
MA:0000520 abdomen muscle
MP:0001259 abnormal body weight
MP:0001348 abnormal lacrimal gland physiology
MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0001406 abnormal gait
MP:0001504 abnormal posture
MP:0001510 abnormal coat appearance
MP:0001513 limb grasping
MP:0001529 abnormal vocalization
MP:0001761 abnormal urination pattern
MP:0002061 abnormal aggression-related behavior
MP:0002066 abnormal motor capabilities/coordination/movement
MP:0002098 abnormal vibrissa morphology
MP:0003492 abnormal involuntary movement
MP:0003671 abnormal eyelid aperture
MP:0005316 abnormal response to tactile stimuli
MP:0013189 abnormal exploration in a new environment
MP:0020147 abnormal defecation amount
VT:0000367 coat/hair morphology trait
VT:0001259 body mass
VT:0001280 vibrissa retention trait
VT:0001392 locomotor behavior trait
VT:0001529 vocalization trait
VT:0003492 involuntary movement trait
VT:0003620 urine output
VT:0005316 tactition trait
VT:0006276 autonomic nervous system physiology trait
VT:0010080 skeletal muscle physiology trait
VT:0010461 excretion behavior trait
VT:0010462 defecation behavior trait
VT:0010471 exploratory behavior trait
VT:0010716 anxiety-related behavior trait
VT:0010726 wildness behavior trait
VT:0015014 aggression-related behavior trait
VT:0015094 equilibrioception system trait
VT:1000000 body conformation trait

Institutional authorship	German Mouse Clinic and Department of Infection Genetics, HZI Lab web site
Investigators	GMC Management Team German Mouse Clinic, Neuherberg GERMANY
Participants	Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Becker L, Klopstock T, Hans W, Lengger C, Kollmus H, Schughart K
Contact	GMC Management Team coregmc@helmholtz-muenchen.de Lab web site
Affiliated Center	German Mouse Clinic (GMC)
Acknowledgements	Funding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type	Phenotype strain survey data set
MPD identifiers	GMC03 MPD:552
Data changelog	No updates/corrections. Initial release date: 02/2020.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

SHIRPA is a standardized set of procedures used to characterize the phenotype of laboratory mice. The procedures are designed as a first-pass phenotyping screen to test muscle function, cerebellar function, sensory function and neuropsychiatric function. The modified SHIRPA includes observations on morphology and dysmorphology. Dysmorphology assessments at 12 wks of age are available in a supplemental data file (see Downloads).

Experimental groups in this study:
• None • None • None • None • None

Procedures conducted:

• observation (SHIRPA)

Behavior, and neurosensory responses (SHIRPA protocol).

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
GMC03:1	GMC03	body weight	(none)	body weight [g] bw 55201	inbred w/CC8	8	both	8-10wks	N=17

GMC03:11	GMC03	observation (SHIRPA)	(none)	coat appearance (1=tidy, 2=irregular) [score] coat_app 55211	inbred w/CC8	8	both	8-10wks	N=17

GMC03:12	GMC03	observation (SHIRPA)	(none)	whiskers (0=present, 1=absent) [score] whiskers 55212	inbred w/CC8	8	both	8-10wks	N=17

GMC03:13	GMC03	observation (SHIRPA)	(none)	body position (0=inactive, 1=active, 2=excessively active) [score] body_pos 55213	inbred w/CC8	8	both	8-10wks	N=17

GMC03:14	GMC03	observation (SHIRPA)	(none)	pelvic elevation (0=less than 5, 1=5 or more, 2=no data) [score] pelvic_elev 55214	inbred w/CC8	8	both	8-10wks	N=17

GMC03:15	GMC03	observation (SHIRPA)	(none)	tail elevation (0=dragging, 1=horizontal, 2=elevated) [score] tail_elev 55215	inbred w/CC8	8	both	8-10wks	N=17

GMC03:16	GMC03	observation (SHIRPA)	(none)	transfer arousal (0=prolonged freeze, 1=brief freeze, 2=immediate movement) [score] transfer_arousal 55216	inbred w/CC8	8	both	8-10wks	N=17

GMC03:21	GMC03	observation (SHIRPA)	(none)	defecation (0=present, 1=absent) [score] defecation 55221	inbred w/CC8	8	both	8-10wks	N=17

GMC03:22	GMC03	observation (SHIRPA)	(none)	urination (0=present, 1=absent) [score] urinate 55222	inbred w/CC8	8	both	8-10wks	N=17

GMC03:23	GMC03	observation (SHIRPA)	(none)	tremor (0=absent, 1=present) [score] tremor 55223	inbred w/CC8	8	both	8-10wks	N=17

GMC03:24	GMC03	observation (SHIRPA)	(none)	total number of squares entered with all four paws in 30 s [n] loco_activity 55224	inbred w/CC8	8	both	8-10wks	N=17

GMC03:25	GMC03	observation (SHIRPA)	(none)	evidence of biting (0=not aggressive, 1=aggressive) [score] bite_evidence 55225	inbred w/CC8	8	both	8-10wks	N=17

GMC03:26	GMC03	observation (SHIRPA)	(none)	vocalization (0=no, 1=yes) [score] vocalization 55226	inbred w/CC8	8	both	8-10wks	N=17

GMC03:31	GMC03	observation (SHIRPA)	(none)	palebral closure (0=open, 1=closed) [score] palebral_closure 55231	inbred w/CC8	8	both	8-10wks	N=17

GMC03:32	GMC03	observation (SHIRPA)	(none)	lacrimation (0=absent, 1=present) [score] lacrimation 55232	inbred w/CC8	8	both	8-10wks	N=17

GMC03:33	GMC03	observation (SHIRPA)	(none)	startle response, click box (0=no reaction, 1=Preyer reflex, 2=jumping) [score] startle_response 55233	inbred w/CC8	8	both	8-10wks	N=17

GMC03:41	GMC03	observation (SHIRPA)	(none)	limb grasping (0=absent, 1=present) [score] limb_grasping 55241	inbred w/CC8	8	both	8-10wks	N=17

GMC03:42	GMC03	observation (SHIRPA)	(none)	trunk curl (0=absent, 1=present) [score] trunk_curl 55242	inbred w/CC8	8	both	8-10wks	N=17

GMC03:43	GMC03	observation (SHIRPA)	(none)	positional passivity (0=struggle, 3=no) [score] pos_pass 55243	inbred w/CC8	8	both	8-10wks	N=17

GMC03:44	GMC03	observation (SHIRPA)	(none)	gait (0=fluid, 1=abnormal) [score] gait 55244	inbred w/CC8	8	both	8-10wks	N=17

GMC03:51	GMC03	observation (SHIRPA)	(none)	touch escape (0=no response, 1=response to touch, 2=flees prior to touch) [score] touch_escape 55251	inbred w/CC8	8	both	8-10wks	N=17

GMC03:52	GMC03	observation (SHIRPA)	(none)	pinna reflex (0=present, 1=absent) [score] pinna_reflex 55252	inbred w/CC8	8	both	8-10wks	N=17

GMC03:53	GMC03	observation (SHIRPA)	(none)	corneal reflex (0=present, 1=absent) [score] cornea_reflex 55253	inbred w/CC8	8	both	8-10wks	N=17

GMC03:54	GMC03	observation (SHIRPA)	(none)	contact righting reflex (0=present, 1=absent) [score] righting_reflex 55254	inbred w/CC8	8	both	8-10wks	N=17

GMC03: Dysmorphology and SHIRPA behavioral and neuromuscular assessment in 8 inbred founder strains of the Collaborative Cross (2020)