MPD: Phenotype measures mapped to VT:0010487, response to xenobiotic stimulus trait

Phenotype measures in Threadgill2 associated with ontology term
VT:0010487 'response to xenobiotic stimulus trait'

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Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Threadgill2:2	Threadgill2	metabolic panel	acetaminophen	alanine transaminase (serum ALT) [IU/L] ALT 39602 50 mg/kg 300 mg/kg	inbred	5	m	6-8wks	N=5	2005

Threadgill2:3	Threadgill2	histopathology	acetaminophen	liver necrosis score [%] liver_necrosis 39603	inbred	5	m	6-8wks	N=5	2005

Threadgill2:4	Threadgill2	histopathology	acetaminophen	percent nitrotyrosine staining (marker of hepatocyte injury) [%] pct_nitrotyrosine 39604	inbred	5	m	6-8wks	N=5	2005

Threadgill2:5	Threadgill2	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/mg] GSH 39605 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:6	Threadgill2	metabolite quantification	acetaminophen	percent reduced glutathione [%] GSH_pct 39606 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:7	Threadgill2	metabolite quantification	acetaminophen	total glutathione [µmol/mg] GSH_total 39607 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:9	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] APAP50 39609 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:16	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_50 39616 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:22	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen [µg/mL] APAP_Glc_50 39622 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=4	2005

Threadgill2:32	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] APAP300 39632 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:38	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_300 39638 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:39	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen [µg/mL] APAP_Glc_300 39639 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

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