MPD: Project measures / variables set: Threadgill2 GSH

Project measures / variables set: Threadgill2 GSH

ID, description, units	MPD:39605 GSH reduced glutathione (GSH) [µmol/mg] acetaminophen study
Measures	• control • post-Rx 300 mg/kg
Data set, strains	Threadgill2 inbred 5 strains sex: m age: 6-8wks
Procedure	metabolite quantification
Comparison	control group vs. treated group
Ontology mappings	VT:0000609 liver physiology trait VT:0010487 response to xenobiotic stimulus trait VT:0010516 blood glutathione amount MA:0000358 liver MP:0008872 abnormal physiological response to xenobiotic MP:0011601 abnormal glutathione peroxidase activity

Values Means Δ Means Z-scores

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Threadgill2 - reduced glutathione (GSH)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	68.1953	68.1953	7.0373	0.0126
strain	4	272.1027	68.0257	7.0198	0.0004
group:strain	4	85.5809	21.3952	2.2079	0.092
Residuals	30	290.715	9.6905

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill2	39605	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/mg] control GSH_ctr	inbred	5	m	6-8wks
Threadgill2	39629	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/mg] post-Rx 300 mg/kg GSH_Rx300	inbred	5	m	6-8wks