MPD: Project measures / variables set: Threadgill2 ALT

Project measures / variables set: Threadgill2 ALT

ID, description, units	MPD:39602 ALT alanine transaminase (serum ALT) [IU/L] acetaminophen study
Measures	• 50 mg/kg • 300 mg/kg
Data set, strains	Threadgill2 inbred 5 strains sex: m age: 6-8wks
Procedure	metabolic panel
Comparison	multiple dosage cohorts but no control group
Ontology mappings	VT:0010487 response to xenobiotic stimulus trait VT:0001573 blood alanine transaminase amount MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0001573 abnormal circulating alanine transaminase level

Values Means Δ Means Z-scores

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Threadgill2 - alanine transaminase (serum ALT)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	1	104896680.3478	104896680.3478	120.8467	< 0.0001
strain	4	803819.893	200954.9732	0.2315	0.9189
dose:strain	4	762715.8787	190678.9697	0.2197	0.9257
Residuals	36	31248520.75	868014.4653

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill2	39602	metabolic panel	acetaminophen	alanine transaminase (serum ALT) [IU/L] dose: 50 mg/kg ALT_Rx50	inbred	5	m	6-8wks
Threadgill2	39628	metabolic panel	acetaminophen	alanine transaminase (serum ALT) [IU/L] dose: 300 mg/kg ALT_Rx300	inbred	5	m	6-8wks