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Project measures / variables set:   Threadgill2   APAP_Glc_50

ID, description, units MPD:39622   APAP_Glc_50   serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]  
acetaminophen study
Measures
• baseline    • 0.5h    • 1h    • 2h    • 3h    • 6h
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Comparisontimecourse, same cohort
Ontology mappings

  SIDE-BY-SIDE STRAIN CURVES
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  OVERLAPPING STRAIN CURVES
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen



  ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary          "within" = Within error     "between" = Between Error (Animal ID)

Factor DF Sum of squares Mean sum of squares F value p-value (Pr>F)
between   strain 3 3093.9052 1031.3017 4.8502 0.033
between   Residuals 8 1701.0324 212.6291
within   group 5 9661.9639 1932.3928 27.4293 < 0.0001
within   group:strain 15 5314.8579 354.3239 5.0294 < 0.0001
within   Residuals 40 2817.9947 70.4499

Q-Q normality assessment based on residuals

  


  INDIVIDUAL MEASURES
ProjectIDTreatmentMeasure / Variable Description PanelStrains
tested		SexAge
Threadgill2 39622 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]   baseline  APAP_Glc_50_0 inbred 5 m 6-8wks
Threadgill2 39623 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]   0.5h  APAP_Glc_50_0.5 inbred 5 m 6-8wks
Threadgill2 39624 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]   1h  APAP_Glc_50_1 inbred 5 m 6-8wks
Threadgill2 39625 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]   2h  APAP_Glc_50_2 inbred 5 m 6-8wks
Threadgill2 39626 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]   3h  APAP_Glc_50_3 inbred 5 m 6-8wks
Threadgill2 39627 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]   6h  APAP_Glc_50_6 inbred 5 m 6-8wks



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