MPD: Data set: Naggert1

Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol. 2007 Jun;102(6):2369-78. Epub 2007 Feb 22. PubMed 17317875

Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genomics. 2008 Mar 14;33(1):26-32. Epub 2008 Jan 29. PubMed 18230669

Naggert1 downloads
• Download Naggert1 project data set animal data, as uploaded
• Download Naggert1 animal data matrix with factor-related expansion applied as necessary
• Download Naggert1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Naggert1 measures:

MA:0000009 adipose tissue
MA:0001459 bone
MA:0002501 plasma
MP:0000188 abnormal circulating glucose level
MP:0001259 abnormal body weight
MP:0001560 abnormal circulating insulin level
MP:0002089 abnormal postnatal growth/weight/body size
MP:0003959 abnormal lean body mass
MP:0005452 abnormal adipose tissue amount
MP:0005457 abnormal percent body fat/body weight
MP:0005667 abnormal circulating leptin level
MP:0010119 abnormal bone mineral density
MP:0010122 abnormal bone mineral content
MP:0012321 abnormal total tissue mass
VT:0000188 blood glucose amount
VT:0001259 body mass
VT:0001560 blood insulin amount
VT:0005007 bone mineral mass
VT:0005452 adipose amount
VT:0005667 blood leptin amount
VT:0010482 body fat mass
VT:0010483 body lean mass

Investigators	Jürgen Naggert The Jackson Laboratory, Bar Harbor, ME Karen L Svenson The Jackson Laboratory, Bar Harbor, ME Randy V Smith The Jackson Laboratory, Bar Harbor, ME Beverly Paigen The Jackson Laboratory, Bar Harbor, ME Luanne L Peters The Jackson Laboratory, Bar Harbor, ME
Contact	Jürgen Naggert jkn@jax.org
Affiliated Center	JAX Heart, Lung, and Blood Center (HLB)
Acknowledgements	Funding provided by NIH Program for Genomic Applications (PGA) HL66611. In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type	Phenotype strain survey data set
MPD identifiers	Naggert1 MPD:143
Data changelog	6 updates/corrections. Initial release date: 05/2003.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Procedures conducted:

• body weight		High-fat diet for 8wks.
• DXA		Body mass, fat mass, lean mass, bone mineral density and content after 8wks on high-fat diet.
• metabolic panel		Glucose (plasma). Baseline vs. high-fat diet (17wks). 4h fast.
• hormone quantification		Insulin and leptin after 18wks on high-fat diet. Multiple readings per animal were averaged.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Naggert1:2	Naggert1	metabolic panel	high-fat diet	glucose (plasma GLU, 4h fast) [mg/dL] GLU 14302 baseline after 17wks on diet Δchange	inbred w/CC7	43	both	7-9wks	N=10

Naggert1:5	Naggert1	hormone quantification	high-fat diet	insulin [ng/mL] INS_fat18 14305	inbred w/CC7	43	both	25-27wks	N=12

Naggert1:6	Naggert1	hormone quantification	high-fat diet	leptin [pg/mL] LEP_fat18 14306	inbred w/CC7	43	both	25-27wks	N=11

Naggert1:8	Naggert1	body weight	high-fat diet	body weight [g] bw_fat8 14308	inbred w/CC7	41	both	15-17wks	N=10

Naggert1:12	Naggert1	DXA	high-fat diet	bone mineral density (BMD) [g/cm²] BMD_fat8 14312	inbred w/CC7	41	both	15-17wks	N=10

Naggert1:14	Naggert1	DXA	high-fat diet	bone mineral content (BMC) [g] BMC_fat8 14314	inbred w/CC7	41	both	15-17wks	N=10

Naggert1:16	Naggert1	DXA	high-fat diet	total tissue mass, head excluded [g] tissuemass_fat8 14316	inbred w/CC7	41	both	15-17wks	N=10

Naggert1:17	Naggert1	DXA	high-fat diet	weight of fat portion of tissue mass, head excluded [g] fatwt_fat8 14317	inbred w/CC7	41	both	15-17wks	N=10

Naggert1:18	Naggert1	DXA	high-fat diet	weight of lean portion of tissue mass, head excluded [g] leanwt_fat8 14318	inbred w/CC7	41	both	15-17wks	N=10

Naggert1:19	Naggert1	DXA	high-fat diet	percentage of tissue mass that is fat, head excluded [%] pctfat_fat8 14319	inbred w/CC7	41	both	15-17wks	N=10

Naggert1: Diet effects on bone mineral density and content, body composition, and plasma glucose, leptin, and insulin levels in 43 inbred strains of mice on a high-fat atherogenic diet (2003)