Project measure / variable:   Naggert1   LEP_fat18

ID, description, units MPD:14306   LEP_fat18   leptin   [pg/mL]  
high-fat diet study
Data set, strains Naggert1   inbred w/CC7   43 strains     sex: both     age: 25-27wks
Procedure hormone quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Naggert1 - leptin



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested42 strains43 strains
Mean of the strain means11302   pg/mL 12347   pg/mL
Median of the strain means8934   pg/mL 9854   pg/mL
SD of the strain means± 7463 ± 9727
Coefficient of variation (CV)0.660 0.788
Min–max range of strain means2323   –   31880   pg/mL 1371   –   45986   pg/mL
Mean sample size per strain12.0   mice 10.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 530294633.6615 530294633.6615 8.8497 0.003
strain 41 56562731324.9519 1379578812.8037 23.0228 < 0.0001
sex:strain 41 7005820442.9116 170873669.3393 2.8516 < 0.0001
Residuals 873 52312104793.2886 59922227.7128


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 11571.0 4849.0   14 1296.0 0.419 4813.0, 24362.0 0.04
129S1/SvImJ m 22211.0 9208.0   11 2776.0 0.415 7516.0, 36800.0 1.01
A/J f 6781.0 3051.0   14 815.0 0.45 2321.0, 13093.0 -0.61
A/J m 5564.0 2496.0   14 667.0 0.449 1232.0, 10847.0 -0.7
AKR/J f 17198.0 14444.0   9 4815.0 0.84 1015.0, 43885.0 0.79
AKR/J m 22734.0 10757.0   9 3586.0 0.473 773.0, 35880.0 1.07
BALB/cByJ f 5834.0 2664.0   12 769.0 0.457 3626.0, 11717.0 -0.73
BALB/cByJ m 2132.0 933.0   10 295.0 0.438 677.0, 3515.0 -1.05
BALB/cJ f 13548.0 6314.0   14 1688.0 0.466 5790.0, 25770.0 0.3
BALB/cJ m 2966.0 587.0   10 185.0 0.198 2223.0, 3874.0 -0.96
BTBR T+ Itpr3tf/J f 7184.0 2510.0   11 757.0 0.349 2228.0, 10963.0 -0.55
BTBR T+ Itpr3tf/J m 9413.0 5070.0   12 1464.0 0.539 2078.0, 20465.0 -0.3
BUB/BnJ f 5509.0 2257.0   9 752.0 0.41 1252.0, 8893.0 -0.78
BUB/BnJ m 6362.0 2866.0   10 906.0 0.45 2396.0, 11321.0 -0.62
C3H/HeJ f 4790.0 2468.0   10 780.0 0.515 1685.0, 9719.0 -0.87
C3H/HeJ m 8459.0 5404.0   10 1709.0 0.639 1584.0, 18882.0 -0.4
C57BL/10J f 6329.0 1725.0   14 461.0 0.273 2979.0, 10178.0 -0.67
C57BL/10J m 7127.0 3999.0   9 1333.0 0.561 2652.0, 13532.0 -0.54
C57BL/6J f 5054.0 1661.0   18 392.0 0.329 2396.0, 8160.0 -0.84
C57BL/6J m 3600.0 2067.0   16 517.0 0.574 1444.0, 10305.0 -0.9
C57BLKS/J f 5854.0 4655.0   17 1129.0 0.795 674.0, 15602.0 -0.73
C57BLKS/J m 7299.0 2286.0   11 689.0 0.313 4049.0, 11822.0 -0.52
C57BR/cdJ f 5142.0 2923.0   16 731.0 0.568 1244.0, 12503.0 -0.83
C57BR/cdJ m 16878.0 15936.0   10 5039.0 0.944 2780.0, 51814.0 0.47
C57L/J f 5952.0 3617.0   11 1090.0 0.608 1382.0, 13483.0 -0.72
C57L/J m 5250.0 3285.0   10 1039.0 0.626 1150.0, 11331.0 -0.73
C58/J f 4023.0 6111.0   18 1440.0 1.52 278.0, 25529.0 -0.98
C58/J m 2855.0 3060.0   14 818.0 1.07 104.0, 11394.0 -0.98
CAST/EiJ f 13507.0 15543.0   11 4687.0 1.15 5226.0, 49697.0 0.3
CAST/EiJ m 10216.0 4782.0   10 1512.0 0.468 2360.0, 17894.0 -0.22
CBA/J f 20483.0 8426.0   18 1986.0 0.411 4229.0, 36748.0 1.23
CBA/J m 19518.0 8602.0   12 2483.0 0.441 10221.0, 37699.0 0.74
CE/J f 24094.0 7316.0   8 2587.0 0.304 15245.0, 36913.0 1.71
CE/J m 19314.0 11087.0   18 2613.0 0.574 1773.0, 39872.0 0.72
CZECHII/EiJ f 2542.0 1425.0   12 411.0 0.56 913.0, 5152.0 -1.17
CZECHII/EiJ m 4993.0 3708.0   13 1029.0 0.743 795.0, 12436.0 -0.76
DBA/1J f 7805.0 4289.0   10 1356.0 0.55 2913.0, 15796.0 -0.47
DBA/1J m 10743.0 4490.0   15 1159.0 0.418 4753.0, 18408.0 -0.16
DBA/2J f 18158.0 9176.0   10 2902.0 0.505 7620.0, 38772.0 0.92
DBA/2J m 22127.0 13397.0   14 3581.0 0.605 4006.0, 41688.0 1.01
FVB/NJ f 9614.0 4267.0   10 1349.0 0.444 5185.0, 18631.0 -0.23
FVB/NJ m 3443.0 2466.0   6 1007.0 0.716 1035.0, 6700.0 -0.92
I/LnJ f 9955.0 6747.0   13 1871.0 0.678 1769.0, 21870.0 -0.18
I/LnJ m 12067.0 4880.0   9 1627.0 0.404 3392.0, 19254.0 -0.03
JF1/MsJ f 16879.0 5869.0   12 1694.0 0.348 6589.0, 23884.0 0.75
JF1/MsJ m 16601.0 9988.0   17 2422.0 0.602 2265.0, 45835.0 0.44
KK/HlJ f 31498.0 15457.0   10 4888.0 0.491 5742.0, 58072.0 2.71
KK/HlJ m 45986.0 10427.0   9 3476.0 0.227 25863.0, 59386.0 3.46
LP/J f 14145.0 9910.0   10 3134.0 0.701 1203.0, 34238.0 0.38
LP/J m 29629.0 17491.0   10 5531.0 0.59 6865.0, 47751.0 1.78
MA/MyJ m 5984.0 3710.0   10 1173.0 0.62 1411.0, 12613.0 -0.65
MOLF/EiJ f 2323.0 1822.0   10 576.0 0.785 329.0, 5206.0 -1.2
MOLF/EiJ m 1371.0 1356.0   9 452.0 0.988 74.3, 4593.0 -1.13
MSM/MsJ f 9574.0 7746.0   12 2236.0 0.809 2099.0, 30193.0 -0.23
MSM/MsJ m 9854.0 4932.0   8 1744.0 0.501 2929.0, 19312.0 -0.26
NOD/ShiLtJ f 6541.0 9593.0   13 2661.0 1.47 394.0, 37212.0 -0.64
NOD/ShiLtJ m 8797.0 10118.0   10 3200.0 1.15 2113.0, 36339.0 -0.36
NON/ShiLtJ f 8827.0 4058.0   13 1126.0 0.46 3250.0, 14371.0 -0.33
NON/ShiLtJ m 10813.0 7345.0   13 2037.0 0.679 3012.0, 27601.0 -0.16
NZB/BlNJ f 23739.0 16279.0   8 5755.0 0.686 4605.0, 53854.0 1.67
NZB/BlNJ m 16710.0 8892.0   6 3630.0 0.532 5566.0, 30518.0 0.45
NZW/LacJ f 20904.0 8728.0   11 2632.0 0.418 9634.0, 33697.0 1.29
NZW/LacJ m 20138.0 16017.0   11 4829.0 0.795 4315.0, 56169.0 0.8
PERA/EiJ f 19540.0 8414.0   12 2429.0 0.431 6332.0, 39109.0 1.1
PERA/EiJ m 7150.0 4677.0   7 1768.0 0.654 2233.0, 15405.0 -0.53
PL/J f 6020.0 2981.0   9 994.0 0.495 2635.0, 12712.0 -0.71
PL/J m 16348.0 6319.0   10 1998.0 0.387 3860.0, 22595.0 0.41
PWK/PhJ f 15330.0 3059.0   12 883.0 0.2 10850.0, 22457.0 0.54
PWK/PhJ m 13939.0 9547.0   11 2878.0 0.685 5609.0, 37793.0 0.16
RF/J f 31880.0 16975.0   10 5368.0 0.532 11982.0, 55466.0 2.76
RF/J m 40970.0 14176.0   8 5012.0 0.346 12551.0, 58964.0 2.94
RIIIS/J f 7603.0 3093.0   9 1031.0 0.407 3810.0, 12210.0 -0.5
RIIIS/J m 10231.0 4711.0   9 1570.0 0.461 4183.0, 17607.0 -0.22
SEA/GnJ f 11016.0 4496.0   19 1031.0 0.408 3476.0, 24729.0 -0.04
SEA/GnJ m 11060.0 4432.0   11 1336.0 0.401 4024.0, 19091.0 -0.13
SJL/J f 9040.0 6151.0   10 1945.0 0.68 1581.0, 20567.0 -0.3
SJL/J m 5009.0 3460.0   11 1043.0 0.691 316.0, 9968.0 -0.75
SM/J f 5643.0 1708.0   8 604.0 0.303 2670.0, 8228.0 -0.76
SM/J m 6632.0 4193.0   8 1483.0 0.632 1348.0, 14257.0 -0.59
SPRET/EiJ f 14166.0 8017.0   4 4009.0 0.566 6711.0, 22918.0 0.38
SPRET/EiJ m 19219.0 23630.0   7 8931.0 1.23 3001.0, 67491.0 0.71
SWR/J f 5510.0 2562.0   14 685.0 0.465 2998.0, 11279.0 -0.78
SWR/J m 6790.0 11263.0   14 3010.0 1.66 426.0, 44476.0 -0.57
WSB/EiJ f 3581.0 2511.0   17 609.0 0.701 959.0, 9401.0 -1.03
WSB/EiJ m 2404.0 1591.0   13 441.0 0.662 182.0, 4866.0 -1.02


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 11570.7857 2068.8545 15631.2956 7510.2758
129S1/SvImJ m 22211.2727 2333.9827 26792.1457 17630.3997
A/J f 6781.2857 2068.8545 10841.7956 2720.7758
A/J m 5564.0 2068.8545 9624.5099 1503.4901
AKR/J f 17198.2222 2580.315 22262.5679 12133.8766
AKR/J m 22733.8889 2580.315 27798.2345 17669.5432
BALB/cByJ f 5834.0 2234.6183 10219.852 1448.148
BALB/cByJ m 2131.6 2447.9017 6936.0601 0.0
BALB/cJ f 13547.6429 2068.8545 17608.1528 9487.1329
BALB/cJ m 2966.1 2447.9017 7770.5601 0.0
BTBR T+ Itpr3tf/J f 7183.8182 2333.9827 11764.6912 2602.9452
BTBR T+ Itpr3tf/J m 9412.8333 2234.6183 13798.6853 5026.9813
BUB/BnJ f 5508.8889 2580.315 10573.2345 444.5432
BUB/BnJ m 6362.0 2447.9017 11166.4601 1557.5399
C3H/HeJ f 4789.5 2447.9017 9593.9601 0.0
C3H/HeJ m 8458.8 2447.9017 13263.2601 3654.3399
C57BL/10J f 6329.0 2068.8545 10389.5099 2268.4901
C57BL/10J m 7127.4444 2580.315 12191.7901 2063.0988
C57BL/6J f 5054.1111 1824.5582 8635.1443 1473.078
C57BL/6J m 3600.125 1935.2362 7398.3842 0.0
C57BLKS/J f 5853.9412 1877.4549 9538.7939 2169.0885
C57BLKS/J m 7298.9091 2333.9827 11879.7821 2718.0361
C57BR/cdJ f 5142.3125 1935.2362 8940.5717 1344.0533
C57BR/cdJ m 16877.5 2447.9017 21681.9601 12073.0399
C57L/J f 5951.7273 2333.9827 10532.6003 1370.8543
C57L/J m 5250.0 2447.9017 10054.4601 445.5399
C58/J f 4023.3889 1824.5582 7604.422 442.3557
C58/J m 2854.9286 2068.8545 6915.4385 0.0
CAST/EiJ f 13507.0909 2333.9827 18087.9639 8926.2179
CAST/EiJ m 10216.0 2447.9017 15020.4601 5411.5399
CBA/J f 20482.6667 1824.5582 24063.6998 16901.6335
CBA/J m 19518.25 2234.6183 23904.102 15132.398
CE/J f 24093.5 2736.8373 29465.0497 18721.9503
CE/J m 19314.1667 1824.5582 22895.1998 15733.1335
CZECHII/EiJ f 2542.3333 2234.6183 6928.1853 0.0
CZECHII/EiJ m 4992.6154 2146.9518 9206.4057 778.8251
DBA/1J f 7804.9 2447.9017 12609.3601 3000.4399
DBA/1J m 10743.2667 1998.7034 14666.0919 6820.4414
DBA/2J f 18157.7 2447.9017 22962.1601 13353.2399
DBA/2J m 22126.8571 2068.8545 26187.3671 18066.3472
FVB/NJ f 9614.4 2447.9017 14418.8601 4809.9399
FVB/NJ m 3443.3333 3160.2275 9645.8647 0.0
I/LnJ f 9955.2308 2146.9518 14169.0211 5741.4405
I/LnJ m 12067.2222 2580.315 17131.5679 7002.8766
JF1/MsJ f 16878.5833 2234.6183 21264.4353 12492.7313
JF1/MsJ m 16600.8824 1877.4549 20285.7351 12916.0296
KK/HlJ f 31497.6 2447.9017 36302.0601 26693.1399
KK/HlJ m 45986.0 2580.315 51050.3457 40921.6543
LP/J f 14145.0 2447.9017 18949.4601 9340.5399
LP/J m 29629.3 2447.9017 34433.7601 24824.8399
MOLF/EiJ f 2322.7 2447.9017 7127.1601 0.0
MOLF/EiJ m 1371.3667 2580.315 6435.7123 0.0
MSM/MsJ f 9574.3333 2234.6183 13960.1853 5188.4813
MSM/MsJ m 9853.625 2736.8373 15225.1747 4482.0753
NOD/ShiLtJ f 6541.1538 2146.9518 10754.9441 2327.3636
NOD/ShiLtJ m 8797.0 2447.9017 13601.4601 3992.5399
NON/ShiLtJ f 8827.1538 2146.9518 13040.9441 4613.3636
NON/ShiLtJ m 10813.3077 2146.9518 15027.098 6599.5174
NZB/BlNJ f 23739.125 2736.8373 29110.6747 18367.5753
NZB/BlNJ m 16710.3333 3160.2275 22912.8647 10507.802
NZW/LacJ f 20904.0 2333.9827 25484.873 16323.127
NZW/LacJ m 20137.8182 2333.9827 24718.6912 15556.9452
PERA/EiJ f 19539.6667 2234.6183 23925.5187 15153.8147
PERA/EiJ m 7150.4286 2925.8022 12892.8568 1408.0004
PL/J f 6019.8889 2580.315 11084.2345 955.5432
PL/J m 16348.3 2447.9017 21152.7601 11543.8399
PWK/PhJ f 15330.4167 2234.6183 19716.2687 10944.5647
PWK/PhJ m 13939.2727 2333.9827 18520.1457 9358.3997
RF/J f 31879.8 2447.9017 36684.2601 27075.3399
RF/J m 40970.25 2736.8373 46341.7997 35598.7003
RIIIS/J f 7603.0 2580.315 12667.3457 2538.6543
RIIIS/J m 10230.7778 2580.315 15295.1234 5166.4321
SEA/GnJ f 11015.5263 1775.8946 14501.048 7530.0046
SEA/GnJ m 11060.4545 2333.9827 15641.3275 6479.5815
SJL/J f 9039.9 2447.9017 13844.3601 4235.4399
SJL/J m 5009.4545 2333.9827 9590.3275 428.5815
SM/J f 5643.375 2736.8373 11014.9247 271.8253
SM/J m 6632.125 2736.8373 12003.6747 1260.5753
SPRET/EiJ f 14165.5 3870.4724 21762.0185 6568.9815
SPRET/EiJ m 19218.8571 2925.8022 24961.2853 13476.4289
SWR/J f 5510.0714 2068.8545 9570.5814 1449.5615
SWR/J m 6789.7143 2068.8545 10850.2242 2729.2044
WSB/EiJ f 3580.6471 1877.4549 7265.4998 0.0
WSB/EiJ m 2404.3846 2146.9518 6618.1749 0.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 16891.0292 1559.4578 19951.7537 13830.3047
A/J both 6172.6429 1462.9011 9043.857 3301.4288
AKR/J both 19966.0556 1824.5582 23547.0887 16385.0224
BALB/cByJ both 3982.8 1657.2373 7235.4349 730.1651
BALB/cJ both 8256.8714 1602.5278 11402.1289 5111.614
BTBR T+ Itpr3tf/J both 8298.3258 1615.6264 11469.2915 5127.36
BUB/BnJ both 5935.4444 1778.3594 9425.8038 2445.0851
C3H/HeJ both 6624.15 1730.9279 10021.4163 3226.8837
C57BL/10J both 6728.2222 1653.6463 9973.8091 3482.6353
C57BL/6J both 4327.1181 1329.8639 6937.2221 1717.014
C57BLKS/J both 6576.4251 1497.6909 9515.9207 3636.9296
C57BR/cdJ both 11009.9063 1560.2373 14072.1607 7947.6518
C57L/J both 5600.8636 1691.1311 8920.0215 2281.7058
C58/J both 3439.1587 1379.2364 6146.1653 732.1521
CAST/EiJ both 11861.5455 1691.1311 15180.7033 8542.3876
CBA/J both 20000.4583 1442.4399 22831.5136 17169.403
CE/J both 21703.8333 1644.6345 24931.733 18475.9337
CZECHII/EiJ both 3767.4744 1549.429 6808.5156 726.4332
DBA/1J both 9274.0833 1580.1138 12375.349 6172.8177
DBA/2J both 20142.2786 1602.5278 23287.536 16997.0211
FVB/NJ both 6528.8667 1998.7034 10451.6919 2606.0414
I/LnJ both 11011.2265 1678.3494 14305.2979 7717.1551
JF1/MsJ both 16739.7328 1459.3111 19603.901 13875.5647
KK/HlJ both 38741.8 1778.3594 42232.1594 35251.4406
LP/J both 21887.15 1730.9279 25284.4163 18489.8837
MOLF/EiJ both 1847.0333 1778.3594 5337.3927 0.0
MSM/MsJ both 9713.9792 1766.6209 13181.2996 6246.6587
NOD/ShiLtJ both 7669.0769 1628.0068 10864.3416 4473.8122
NON/ShiLtJ both 9820.2308 1518.1242 12799.8305 6840.6311
NZB/BlNJ both 20224.7292 2090.294 24327.318 16122.1403
NZW/LacJ both 20520.9091 1650.375 23760.0755 17281.7427
PERA/EiJ both 13345.0476 1840.7768 16957.9128 9732.1824
PL/J both 11184.0944 1778.3594 14674.4538 7693.7351
PWK/PhJ both 14634.8447 1615.6264 17805.8104 11463.8789
RF/J both 36425.025 1835.9263 40028.3701 32821.6799
RIIIS/J both 8916.8889 1824.5582 12497.922 5335.8557
SEA/GnJ both 11037.9904 1466.3967 13916.0653 8159.9156
SJL/J both 7024.6773 1691.1311 10343.8351 3705.5194
SM/J both 6137.75 1935.2362 9936.0092 2339.4908
SPRET/EiJ both 16692.1786 2425.947 21453.5485 11930.8086
SWR/J both 6149.8929 1462.9011 9021.107 3278.6788
WSB/EiJ both 2992.5158 1426.0294 5791.3624 193.6693




  GWAS USING LINEAR MIXED MODELS