MPD: Data set: GMC14

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14. PubMed 32060626 FullText

GMC14 downloads
• Download GMC14 project data set animal data, as uploaded
• Download GMC14 animal data matrix with factor-related expansion applied as necessary
• Download GMC14 strain means, SD, N, etc. one row per strain/sex/measure
• GMC14 supplementary data

Ontology terms mapped to GMC14 measures:

MA:0000261 eye
MP:0001256 abnormal body length
MP:0001259 abnormal body weight
MP:0001303 abnormal lens morphology
MP:0001325 abnormal retina morphology
MP:0002090 abnormal vision
MP:0002697 abnormal eye size
MP:0002864 abnormal ocular fundus morphology
VT:0001256 body length
VT:0001259 body mass
VT:0001303 lens morphology trait
VT:0001325 retina morphology trait
VT:0002090 vision trait
VT:0002697 eye size trait
VT:0002864 ocular fundus morphology trait

Institutional authorship	German Mouse Clinic and Department of Infection Genetics, HZI Lab web site
Investigators	GMC Management Team German Mouse Clinic, Neuherberg GERMANY
Participants	Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Amarie O-V, Graw J, Lengger C, Kollmus H, Schughart K
Contact	GMC Management Team coregmc@helmholtz-muenchen.de Lab web site
Affiliated Center	German Mouse Clinic (GMC)
Acknowledgements	Funding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type	Phenotype strain survey data set
MPD identifiers	GMC14 MPD:563
Data changelog	No updates/corrections. Initial release date: 02/2020.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Experimental groups in this study:
• None • None • None • None

Procedures conducted:

• organ dimensions		Axial length of eye.
• Scheimpflug imaging		Eye lens density.
• computed tomography		Retinal thickness and fundus vessels.
• virtual optomotor		Threshold of spatial frequency.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
GMC14:1	GMC14	body size and weight	(none)	body weight [g] bw 56301	inbred w/CC8	8	both	14-16wks	N=13

GMC14:2	GMC14	body size and weight	(none)	body length [mm] body_length 56302	inbred w/CC8	8	both	14-16wks	N=13

GMC14:21	GMC14	organ dimensions	(none)	eye axial length [mm] eye_length 56321 left eye right eye	inbred w/CC8	8	both	15-16wks	N=13

GMC14:31	GMC14	Scheimpflug imaging	(none)	minimal density value of lens, Scheimpflug imaging [%] lens_min_density 56331 left eye right eye	inbred w/CC8	8	both	15-16wks	N=13

GMC14:33	GMC14	Scheimpflug imaging	(none)	maximal density value of lens, Scheimpflug imaging [%] lens_max_density 56333 left eye right eye	inbred w/CC8	8	both	15-16wks	N=13

GMC14:35	GMC14	Scheimpflug imaging	(none)	mean density value of lens, Scheimpflug imaging [%] lens_mean_density 56335 left eye right eye	inbred w/CC8	8	both	15-16wks	N=13

GMC14:41	GMC14	computed tomography	(none)	number of main vessels in fundus [n] fundus_vessels 56341 left eye right eye	inbred w/CC8	8	both	15-17wks	N=12

GMC14:51	GMC14	computed tomography	(none)	retinal thickness, optical coherence tomography [µm] retinal_thickness 56351 left eye right eye	inbred w/CC8	8	both	15-17wks	N=13

GMC14:61	GMC14	virtual optomotor	(none)	threshold of spatial frequency (number of cycles that fall within one degree of visual angle), virtual drum [n/deg] spatial_freq 56361	inbred w/CC8	3	both	14-16wks	N=16

GMC14: Eye morphology and vision assessment in 8 inbred founder strains of the Collaborative Cross (2020)