MPD: Data set: GMC20

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14. PubMed 32060626 FullText

GMC20 downloads
• Download GMC20 project data set animal data, as uploaded
• Download GMC20 animal data matrix with factor-related expansion applied as necessary
• Download GMC20 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to GMC20 measures:

MA:0002501 plasma
MP:0001844 autoimmune response
MP:0020171 abnormal IgA level
MP:0020173 abnormal IgE level
MP:0020175 abnormal IgG1 level
MP:0020176 abnormal IgG2a level
MP:0020177 abnormal IgG2b level
MP:0020179 abnormal IgG3 level
MP:0020180 abnormal IgM level
VT:0001807 blood immunoglobulin A amount
VT:0002144 B cell development trait
VT:0002492 blood immunoglobulin E amount
VT:0003725 blood autoantibody amount
VT:0004762 blood anti-double stranded DNA antibody amount
VT:0008495 blood immunoglobulin G1 amount
VT:0008496 blood immunoglobulin G2a amount
VT:0008497 blood immunoglobulin G2b amount
VT:0008498 blood immunoglobulin G3 amount
VT:0010481 blood immunoglobulin M amount

Institutional authorship	German Mouse Clinic and Department of Infection Genetics, HZI Lab web site
Investigators	GMC Management Team German Mouse Clinic, Neuherberg GERMANY
Participants	Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Adler T, Treise I, Busch D, Aguilar-Pimentel A, Ollert M, Lengger C, Kollmus H, Schughart K
Contact	GMC Management Team coregmc@helmholtz-muenchen.de Lab web site
Affiliated Center	German Mouse Clinic (GMC)
Acknowledgements	Funding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type	Phenotype strain survey data set
MPD identifiers	GMC20 MPD:569
Data changelog	No updates/corrections. Initial release date: 02/2020.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Experimental groups in this study:
• None • None • None • None

Procedures conducted:

• immunoglobulin quantification		Immunoglobulins (plasma).
• autoantibody quantification		Anti-DNA autoantibodies, rheumatoid factor.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Sample Size (Avg)
GMC20:2	GMC20	immunoglobulin quantification	(none)	immunoglobulin M (plasma IgM) [µg/mL] IgM 56902 age 16-17wks 20-21wks	inbred w/CC8	8	both	N=6

GMC20:4	GMC20	immunoglobulin quantification	(none)	immunoglobulin A (plasma IgA) [µg/mL] IgA 56904 age 16-17wks 20-21wks	inbred w/CC8	8	both	N=5

GMC20:6	GMC20	immunoglobulin quantification	(none)	immunoglobulin G1 (plasma IgG1) [µg/mL] IgG1 56906 age 16-17wks 20-21wks	inbred w/CC8	8	both	N=4

GMC20:8	GMC20	immunoglobulin quantification	(none)	immunoglobulin G2a (plasma IgG2a) [µg/mL] IgG2a 56908 age 16-17wks 20-21wks	inbred w/CC8	8	both	N=6

GMC20:10	GMC20	immunoglobulin quantification	(none)	immunoglobulin G2b (plasma IgG2b) [µg/mL] IgG2b 56910 age 16-17wks 20-21wks	inbred w/CC8	8	both	N=4

GMC20:12	GMC20	immunoglobulin quantification	(none)	immunoglobulin G3 (plasma IgG3) [µg/mL] IgG3 56912 age 16-17wks 20-21wks	inbred w/CC8	8	both	N=6

GMC20:14	GMC20	immunoglobulin quantification	(none)	immunoglobulin E (plasma IgE) [ng/mL] IgE 56914 age 16-17wks 20-21wks	inbred w/CC8	8	both	N=6

GMC20:16	GMC20	autoantibody quantification	(none)	anti-DNA autoantibodies (plasma) aDNA 56916 age 16-17wks 20-21wks	inbred w/CC8	8	both	N=7

GMC20:18	GMC20	autoantibody quantification	(none)	rheumatoid factor (plasma RF) RF 56918 age 16-17wks 20-21wks	inbred w/CC8	8	both	N=7

GMC20: Circulating immunoglobulins, rheumatoid factor, and anti-DNA antibodies in 8 inbred founder strains of the Collaborative Cross (2020)