GMC08: Transepidermal water loss in 8 inbred founder strains of the Collaborative Cross (2020)

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14.   PubMed 32060626     FullText


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GMC08 downloads
• Download GMC08 project data set     animal data, as uploaded
• Download GMC08 animal data matrix     with factor-related expansion applied as necessary
• Download GMC08 strain means, SD, N, etc.     one row per strain/sex/measure
• GMC08 supplementary data
Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Aguilar-Pimentel A, Ollert M, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     coregmc@helmholtz-muenchen.de     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC08     MPD:557
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Transepidermal water loss (TEWL) is defined as the measurement of the quantity of water that passes from inside the body through the epidermal layer to the surrounding atmosphere via diffusion and evaporation processes. Measurements of TEWL are useful for identifying skin damage caused by pathological conditions such as eczema, chemical exposure, or physical insult, as rates of TEWL increase in proportion to the level of damage.

Experimental groups in this study:
• None     • None     • None     • None     • None    

Procedures conducted:
• transepidermal water loss test  Transepidermal water loss in condenser chamber.

Mice: inbred w/CC8   8 strains   ♀♂   age 11-12wks   5 experimental groups