MPD: Data set: Schonfeld1

Lin X, Yue P, Chen Z, Schonfeld G. Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1179-89. Epub 2004 Dec 9. PubMed 15591160

Schonfeld1 downloads
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• Download Schonfeld1 animal data matrix with factor-related expansion applied as necessary
• Download Schonfeld1 strain means, SD, N, etc. one row per strain/sex/measure
• Schonfeld1 supplementary data

Ontology terms mapped to Schonfeld1 measures:

MA:0000009 adipose tissue
MA:0000059 blood
MA:0000358 liver
MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000188 abnormal circulating glucose level
MP:0001259 abnormal body weight
MP:0001553 abnormal circulating free fatty acids level
MP:0001560 abnormal circulating insulin level
MP:0003457 abnormal circulating ketone body level
MP:0004847 abnormal liver weight
MP:0005291 abnormal glucose tolerance
MP:0005457 abnormal percent body fat/body weight
MP:0006084 abnormal circulating phospholipid level
MP:0011969 abnormal circulating triglyceride level
MP:0012778 abnormal liver triglyceride level
VT:0000180 blood cholesterol amount
VT:0000187 triglyceride amount
VT:0000188 blood glucose amount
VT:0000609 liver physiology trait
VT:0001259 body mass
VT:0001553 blood free fatty acid amount
VT:0001560 blood insulin amount
VT:0002644 blood triglyceride amount
VT:0003402 liver mass
VT:0003457 blood ketone body amount
VT:0005452 adipose amount
VT:0006084 blood phospholipid amount
VT:0010482 body fat mass
VT:0015078 blood homeostasis trait
VT:0015088 glucose metabolism trait

Investigators	Gustav Schonfeld Washington University School of Medicine, St. Louis, MO
Participants	Lin X, Yue P, and Chen Z
Contact	Gustav Schonfeld gschonfe@wustl.edu
Acknowledgements	Funding provided by NIH HL42446, HL59515, HL52139, RR00036, DK20579, DK56341, DK52574 Support from the following sources: Alan and Edith Wolf Charitable Fund
Project type	Phenotype strain survey data set
MPD identifiers	Schonfeld1 MPD:323
Data changelog	1 update/correction. Initial release date: 12/2009.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

An investigation of liver triglyceride (TG) levels and development of fatty liver following fasting. Animals were surveyed for blood glucose/insulin metabolism and tolerance, blood and liver lipid metabolism, liver and body weights, and overall fat composition. An analysis (3 strains) of the effect of different fasting times (0h, 6h, 14h) for BHB, FFA, and hTG is available here.

Procedures conducted:

• body weight
• glucose tolerance		0 to 120 min after 10% glucose i.p. 5h fast.
• insulin tolerance		0 to 120 min after insulin i.p. 5h fast.
• lipid profile		Cholesterol, triglycerides, free fatty acids, phospholipids. 5h fast, plasma. Hepatic triglycerides.
• metabolic panel		Glucose, beta-hydroxybutyrate (plasma). No fast.
• organ weights		Liver weight.
• DXA		Fat mass.
• hormone quantification		Insulin level, 30 min post-injection in glucose tolerance test. 10% glucose. 5h fast.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Schonfeld1:1	Schonfeld1	metabolic panel	(none)	glucose (plasma GLU, no fast) [mg/dL] GLU 32301	inbred	11	both	9-13wks	N=6

Schonfeld1:2	Schonfeld1	glucose tolerance	(none)	glucose levels during glucose tolerance test(10% glucose i.p., 5h fast) [mg/dL] GTT 32303 0 min 30 min 60 min 120 min	inbred	10	both	9-13wks	N=5

Schonfeld1:6	Schonfeld1	glucose tolerance	(none)	glucose levels, area under curve, glucose tolerance test (10% glucose i.p., 5h fast) [AUC] AUC_GTT 32308 0 to 60 min 0 to 120 min	inbred	10	both	9-13wks	N=5

Schonfeld1:8	Schonfeld1	hormone quantification	(none)	insulin level (plasma), 30 min post injection in glucose tolerance test (10% glucose i.p., 5h fast) [ng/mL] Insulin 32311	inbred	10	both	9-13wks	N=5

Schonfeld1:9	Schonfeld1	insulin tolerance	(none)	glucose levels as percent of baseline, insulin tolerance test (human insulin 0.75 U/kg bw i.p., 5h fast) [%] pct_ITT 32313 0 min 30 min 60 min 120 min	inbred	10	both	9-13wks	N=5

Schonfeld1:13	Schonfeld1	insulin tolerance	(none)	glucose levels, area under curve, insulin tolerance test (human insulin 0.75 U/kg bw i.p., 5h fast) [AUC] AUC_ITT 32318 0 to 60 min 0 to 120 min	inbred	10	both	9-13wks	N=5

Schonfeld1:15	Schonfeld1	lipid profile	(none)	total cholesterol (plasma CHOL) [mg/dL] TC 32331	inbred	11	both	9-13wks	N=6

Schonfeld1:16	Schonfeld1	lipid profile	(none)	free cholesterol (plasma) [mg/dL] FC 32332	inbred	10	both	9-13wks	N=6

Schonfeld1:17	Schonfeld1	lipid profile	(none)	cholesterol ester (plasma) [mg/dL] CE 32333	inbred	10	both	9-13wks	N=6

Schonfeld1:18	Schonfeld1	lipid profile	(none)	free fatty acids (plasma FFA) [mol/m³] FFA 32334	inbred	10	both	9-13wks	N=5

Schonfeld1:19	Schonfeld1	lipid profile	(none)	phospholipids (plasma) [mg/dL] PL 32335	inbred	10	both	9-13wks	N=6

Schonfeld1:20	Schonfeld1	metabolic panel	(none)	beta-hydroxybutyrate (plasma BHB) [mM] BHB 32340	inbred	10	both	9-13wks	N=6

Schonfeld1:21	Schonfeld1	lipid profile	(none)	triglycerides (plasma TG, 5h fast) [mg/dL] TG 32343	inbred	11	both	9-13wks	N=6

Schonfeld1:22	Schonfeld1	lipid profile	(none)	hepatic triglycerides (5h fast) [mg/g] hTG 32348	inbred	11	both	9-13wks	N=6

Schonfeld1:23	Schonfeld1	DXA	(none)	percent fat, head excluded [%] pct_fat 32351	inbred	10	both	9-13wks	N=6

Schonfeld1:24	Schonfeld1	body weight	(none)	body weight [g] BW 32354	inbred	11	both	9-13wks	N=6

Schonfeld1:25	Schonfeld1	organ weights	(none)	liver weight [g] LW 32361	inbred	11	both	9-13wks	N=6

Schonfeld1:26	Schonfeld1	organ weights	(none)	liver weight as a percent of body weight [%] LW_BW 32362	inbred	11	both	9-13wks	N=6

Schonfeld1:27	Schonfeld1	colony observation	(none)	age at testing (local parameter) [wks] age 32380	inbred	11	both		N=6

Schonfeld1: Strain survey of liver and plasma lipids and blood glucose levels in 11 inbred strains of mice (2005)

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