ITP: ITP2018: Interventions Testing Program: Lifespan effects in UM-HET3 mice treated with fisetin and SG1002 (2024)

Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. Geroscience. 2024 Feb;46(1):795-816. doi: 10.1007/s11357-023-01011-0. Epub 2023 Dec 2.   PubMed 38041783     FullText


         
The Interventions Testing Program (ITP, National Institute on Aging) is a multi-institutional study investigating treatments with the potential to extend lifespan and delay disease and dysfunction in heterogeneous populations of UM-HET3 mice. Such treatments include pharmaceuticals, nutraceuticals, foods, diets, dietary supplements, plant extracts, hormones, peptides, amino acids, chelators, redox agents, and other agents or mixtures of agents.

Experimental groups in this study:
• Control     • Fisetin     • SG1002    

Ontology terms mapped to ITP2018 measures:
  MP:0010768   mortality/aging
  VT:0005372   life span trait

Investigators Richard A Miller       University of Michigan,  Ann Arbor, MI
Randy Strong       University of Texas Health Science Center,  San Antonio, TX
Ron Korstanje       The Jackson Laboratory,  Bar Harbor, ME
David E Harrison       The Jackson Laboratory,  Bar Harbor, ME
Nadia A Rosenthal       The Jackson Laboratory,  Bar Harbor, ME
ContactRichard A Miller     millerr@umich.edu     Lab web site
Affiliated CenterNational Institute on Aging Interventions Testing Program (ITP)
AcknowledgementsFunding provided by NIH AG022303, AG022307, AG022308, AG066346
Project type Phenotype strain survey data set
MPD identifiersITP2018     MPD:1224
Data changelog No updates/corrections.       Initial release date: 03/2025.
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Mice: UM-HET3 population   ♀♂   age various   3 experimental groups

Study results by compound and year

Compound name and (abbreviation) Year
cohort		 Dose in food Age at initiation Compound's
effect on lifespan*		 Other phenotypes
fisetin (Fis) C2018 600 ppm 20 mo (3 days on/11 days off) and 20 mo (continuous) View survival analysis   New
SG1002 (SG1002) C2018 240 ppm 18 mo View survival analysis   New

* Log-rank test p-value on treated vs. control, shown when p ≤ 0.05 for each sex separately. Statistical definitions