GMC10: Body composition assessed by NMR at two ages in 8 inbred founder strains of the Collaborative Cross (2020)

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14.   PubMed 32060626     FullText


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GMC10 downloads
• Download GMC10 project data set     animal data, as uploaded
• Download GMC10 animal data matrix     with factor-related expansion applied as necessary
• Download GMC10 strain means, SD, N, etc.     one row per strain/sex/measure
Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Rozman J, Klingenspor M, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     coregmc@helmholtz-muenchen.de     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC10     MPD:559
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
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Most energy metabolism parameters are related to body mass and body composition. For an accurate evaluation of energy expenditure it is, therefore, of advantage to gain precise knowledge about body composition. Time Domain Nuclear Magnetic Resonance (TD-NMR) provides a precise method for the measurement of lean tissue and body fat in live mice without anesthesia. It uses TD-NMR signals from all protons in the entire sample volume and can provide data on lean and fat mass.

Experimental groups in this study:
• None     • None     • None     • None     • None    

Procedures conducted:
• NMR  Body mass, fat and lean tissue mass.

Mice: inbred w/CC8   8 strains   ♀♂   age 12-13, 18-19wks   5 experimental groups