MPD: Data set: GMC01

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14. PubMed 32060626 FullText

GMC01 downloads
• Download GMC01 project data set animal data, as uploaded
• Download GMC01 animal data matrix with factor-related expansion applied as necessary
• Download GMC01 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to GMC01 measures:

MP:0001259 abnormal body weight
MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0013189 abnormal exploration in a new environment
VT:0001259 body mass
VT:0001392 locomotor behavior trait
VT:0010471 exploratory behavior trait
VT:0010716 anxiety-related behavior trait

Institutional authorship	German Mouse Clinic and Department of Infection Genetics, HZI Lab web site
Investigators	GMC Management Team German Mouse Clinic, Neuherberg GERMANY
Participants	Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Garrett L, Hölter-Koch S, Wurst W, Lengger C, Kollmus H, Schughart K
Contact	GMC Management Team coregmc@helmholtz-muenchen.de Lab web site
Affiliated Center	German Mouse Clinic (GMC)
Acknowledgements	Funding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type	Phenotype strain survey data set
MPD identifiers	GMC01 MPD:550
Data changelog	No updates/corrections. Initial release date: 02/2020.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

The open field test is used to assess anxiety-related and exploratory behaviors. It is based on the natural tendency of an animal to explore and to protect itself which, in this test, translates to spending more time in the periphery of the open field arena than in the center.

Experimental groups in this study:
• None • None • None • None • None

Procedures conducted:

• open field test

Locomotor, exploratory, and anxiety-related behavior. 20 min test some at 5 min intervals.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
GMC01:1	GMC01	body weight	(none)	body weight [g] bw 55001	inbred w/CC8	8	both	8-9wks	N=17

GMC01:11	GMC01	open field test	(none)	distance traveled, successive 5 min intervals [cm] distance 55011 1st 5min 2nd 5min 3rd 5min 4th 5min	inbred w/CC8	8	both	8-9wks	N=17

GMC01:15	GMC01	open field test	(none)	distance traveled total, 20 min test [cm] distance_total 55015	inbred w/CC8	8	both	8-9wks	N=17

GMC01:21	GMC01	open field test	(none)	number of rears, successive 5 min intervals [n] rears 55021 1st 5min 2nd 5min 3rd 5min 4th 5min	inbred w/CC8	8	both	8-9wks	N=17

GMC01:25	GMC01	open field test	(none)	number of rears total, 20 min test [n] rears_total 55025	inbred w/CC8	8	both	8-9wks	N=17

GMC01:31	GMC01	open field test	(none)	resting time in whole arena, 20 min test [s] whole_rest 55031	inbred w/CC8	8	both	8-9wks	N=17

GMC01:32	GMC01	open field test	(none)	average speed in whole arena, 20 min test [cm/s] whole_speed 55032	inbred w/CC8	8	both	8-9wks	N=17

GMC01:41	GMC01	open field test	(none)	distance traveled in center of arena, 20 min test [cm] center_distance 55041	inbred w/CC8	8	both	8-9wks	N=17

GMC01:42	GMC01	open field test	(none)	resting time in center of arena, 20 min test [s] center_rest 55042	inbred w/CC8	8	both	8-9wks	N=17

GMC01:43	GMC01	open field test	(none)	permanence time in center of arena, 20 min test [s] center_permanence 55043	inbred w/CC8	8	both	8-9wks	N=17

GMC01:44	GMC01	open field test	(none)	average speed in center of arena, 20 min test [cm/s] center_speed 55044	inbred w/CC8	8	both	8-9wks	N=17

GMC01:45	GMC01	open field test	(none)	latency to enter in center of arena, 20 min test [s] center_latency 55045	inbred w/CC8	8	both	8-9wks	N=17

GMC01:46	GMC01	open field test	(none)	number of entries in center of arena, 20 min test [n] center_entries 55046	inbred w/CC8	8	both	8-9wks	N=17

GMC01:51	GMC01	open field test	(none)	center distance, successive 5 min intervals [%] center_distance_series 55051 1st 5min 2nd 5min 3rd 5min 4th 5min	inbred w/CC8	8	both	8-9wks	N=17

GMC01:55	GMC01	open field test	(none)	percentage of total distance in center, 20 min test [%] center_distance_total 55055	inbred w/CC8	8	both	8-9wks	N=17

GMC01:61	GMC01	open field test	(none)	center time, successive 5 min intervals [%] center_time 55061 1st 5min 2nd 5min 3rd 5min 4th 5min	inbred w/CC8	8	both	8-9wks	N=17

GMC01:65	GMC01	open field test	(none)	percentage of total time spent in center, 20 min test [%] center_time_total 55065	inbred w/CC8	8	both	8-9wks	N=17

GMC01:71	GMC01	open field test	(none)	distance traveled in periphery, 20 min test [cm] periphery_distance 55071	inbred w/CC8	8	both	8-9wks	N=17

GMC01:72	GMC01	open field test	(none)	resting time in periphery, 20 min test [s] periphery_rest 55072	inbred w/CC8	8	both	8-9wks	N=17

GMC01:73	GMC01	open field test	(none)	permanence time in periphery, 20 min test [s] periphery_permanence 55073	inbred w/CC8	8	both	8-9wks	N=17

GMC01:74	GMC01	open field test	(none)	average speed in periphery, 20 min test [cm/s] periphery_speed 55074	inbred w/CC8	8	both	8-9wks	N=17

GMC01: Locomotor activity and exploratory and anxiety-related behaviors assessed by the open field test in 8 inbred founder strains of the Collaborative Cross (2020)