MPD: Project measures / variables set: Paigen2 nonHDL

Project measures / variables set: Paigen2 nonHDL

ID, description, units	MPD:9905 nonHDL non-HDL cholesterol (plasma) [mg/dL] high-fat diet study
Measures	• baseline • after 17wks on diet • Δchange
Data set, strains	Paigen2 inbred w/CC7 42 strains sex: both age: 7-9wks
Procedure	lipid profile
Comparison	repeated measures, baseline then treated, same cohort
Ontology mappings	VT:0010474 blood non-HDL cholesterol amount MA:0002501 plasma MP:0020151 abnormal circulating non-HDL cholesterol level

Values Means Δ Means Z-scores

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Paigen2 - non-HDL cholesterol (plasma)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	7458.0016	7458.0016	1.831	0.1766
between strain	32	2120459.8741	66264.3711	16.2683	< 0.0001
between sex:strain	32	258153.7634	8067.3051	1.9806	0.0013
between Residuals	495	2016245.1596	4073.2225
within group	1	4573392.9242	4573392.9242	1177.3163	< 0.0001
within group:sex	1	5824.1808	5824.1808	1.4993	0.2214
within group:strain	32	2135674.1911	66739.8185	17.1807	< 0.0001
within group:sex:strain	32	268953.5284	8404.7978	2.1636	0.0003
within Residuals	495	1922872.7977	3884.5915

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Paigen2	9905	lipid profile	high-fat diet	non-HDL cholesterol (plasma) [mg/dL] baseline nonHDL	inbred w/CC7	42	both	7-9wks
Paigen2	9908	lipid profile	high-fat diet	non-HDL cholesterol (plasma) [mg/dL] after 17wks on diet nonHDL_fat17	inbred w/CC7	41	both	7-9wks
Paigen2	9911	lipid profile	high-fat diet	non-HDL cholesterol (plasma) [mg/dL] fold change nonHDL_chg	inbred w/CC7	41	both	7-9wks	(supplemental / summary measure)