MPD: Project measures / variables set: Gould3 FC

Project measures / variables set: Gould3 FC_preCS

ID, description, units	MPD:47361 FC_preCS withdrawal study group, percent immobility in altered context chamber, pre-cue [%] nicotine study
Measures	• control • nicotine dose (mg) • 3 • 6.3 • 12
Data set, strains	Gould3 inbred 8 strains sex: m age: 8-12wks
Procedure	fear conditioning test
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0010715 fear-related behavior trait VT:0010721 response to nicotine trait VT:0010722 withdrawal response to addictive substance trait MP:0003106 abnormal fear-related response MP:0009774 abnormal behavioral withdrawal response MP:0020160 abnormal behavioral response to nicotine

Values Means Δ Means Z-scores

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Gould3 - withdrawal study group, percent immobility in altered context chamber, pre-cue

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	3	528.6436	176.2145	4.2387	0.0059
strain	7	56597.8017	8085.4002	194.4874	< 0.0001
dose:strain	21	1187.1271	56.5299	1.3598	0.1353
Residuals	336	13968.4863	41.5729

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Gould3	47361	fear conditioning test	nicotine	withdrawal study group, percent immobility in altered context chamber, pre-cue [%] control FC_preCS_0	inbred	8	m	8-12wks
Gould3	47362	fear conditioning test	nicotine	withdrawal study group, percent immobility in altered context chamber, pre-cue [%] dose: 3 mg FC_preCS_3	inbred	8	m	8-12wks
Gould3	47363	fear conditioning test	nicotine	withdrawal study group, percent immobility in altered context chamber, pre-cue [%] dose: 6.3 mg FC_preCS_6	inbred	8	m	8-12wks
Gould3	47364	fear conditioning test	nicotine	withdrawal study group, percent immobility in altered context chamber, pre-cue [%] dose: 12 mg FC_preCS_12	inbred	8	m	8-12wks