Project measure / variable:   Threadgill2   APAP_Glc_50_3

ID, description, units MPD:39626   APAP_Glc_50_3   serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]  3h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen 3h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means6.01   µg/mL
Median of the strain means3.86   µg/mL
SD of the strain means± 3.61
Coefficient of variation (CV)0.601
Min–max range of strain means3.05   –   10.4   µg/mL
Mean sample size per strain4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 215.6041 53.901 0.9079 0.4814
Residuals 17 1009.2245 59.3661


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 9.47 14.9   5 6.68 1.58 0.75, 36.0 0.96
C57BL/6J m 10.4 5.74   3 3.32 0.553 6.06, 16.9 1.22
DBA/2J m 3.05 2.66   5 1.19 0.872 0.74, 7.24 -0.82
LP/J m 3.26 1.99   5 0.89 0.611 0.92, 5.19 -0.76
NZW/LacJ m 3.86 1.63   4 0.814 0.422 1.43, 4.88 -0.59


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 9.472 3.4458 16.7419 2.2021
C57BL/6J m 10.3833 4.4485 19.7687 0.9979
DBA/2J m 3.046 3.4458 10.3159 0.0
LP/J m 3.256 3.4458 10.5259 0.0
NZW/LacJ m 3.8575 3.8525 11.9855 0.0




  GWAS USING LINEAR MIXED MODELS