MPD: Project measures / variables set: Crowley1 haloperidol

Project measures / variables set: Crowley1 haloperidol

ID, description, units	MPD:39403 haloperidol plasma haloperidol concentration [nM] haloperidol study
Measures	• day: • 30 • 60 • 90 • 120
Data set, strains	Crowley1 inbred w/CC8 27 strains sex: m age: 9-28wks
Procedure	drug and metabolite quantification
Comparison	timecourse, same cohort
Ontology mappings	VT:0002121 metabolism trait VT:0010487 response to xenobiotic stimulus trait MA:0002501 plasma MP:0008875 abnormal xenobiotic pharmacokinetics

Values Means Δ Means Z-scores

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Crowley1 - plasma haloperidol concentration

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between strain	25	26205.1754	1048.207	12.0195	< 0.0001
between Residuals	122	10639.5139	87.2091
within day	3	40856.2288	13618.7429	892.4468	< 0.0001
within day:strain	75	9316.2245	124.2163	8.14	< 0.0001
within Residuals	366	5585.1617	15.26

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Crowley1	39403	drug and metabolite quantification	haloperidol	plasma haloperidol concentration [nM] on day 30 haloperidol_d30	inbred w/CC8	27	m	9-28wks
Crowley1	39404	drug and metabolite quantification	haloperidol	plasma haloperidol concentration [nM] on day 60 haloperidol_d60	inbred w/CC8	27	m	9-28wks
Crowley1	39405	drug and metabolite quantification	haloperidol	plasma haloperidol concentration [nM] on day 90 haloperidol_d90	inbred w/CC8	26	m	9-28wks
Crowley1	39406	drug and metabolite quantification	haloperidol	plasma haloperidol concentration [nM] on day 120 haloperidol_d120	inbred w/CC8	26	m	9-28wks