Project measure / variable:   Crowley1   haloperidol_d120

ID, description, units MPD:39406   haloperidol_d120   plasma haloperidol concentration   [nM]  on day 120  
haloperidol study
Data set, strains Crowley1   inbred w/CC8   26 strains     sex: m     age: 9-28wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Crowley1 - plasma haloperidol concentration on day 120



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested26 strains
Mean of the strain means5.56   nM
Median of the strain means5.22   nM
SD of the strain means± 1.96
Coefficient of variation (CV)0.352
Min–max range of strain means2.65   –   10.4   nM
Mean sample size per strain5.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 25 503.1895 20.1276 3.9064 < 0.0001
Residuals 122 628.6034 5.1525


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 6.28 2.19   8 0.775 0.35 1.8, 9.1 0.37
A/J m 6.3 1.4   5 0.626 0.222 4.9, 8.5 0.38
AKR/J m 2.66 0.555   5 0.248 0.209 2.0, 3.4 -1.48
BALB/cByJ m 2.65 1.27   4 0.636 0.48 1.6, 4.5 -1.49
BTBR T+ Itpr3tf/J m 6.21 3.75   8 1.33 0.604 1.8, 12.3 0.33
C3H/HeJ m 4.77 0.538   4 0.269 0.113 4.1, 5.3 -0.4
C57BL/6J m 3.44 1.11   5 0.495 0.321 2.3, 4.8 -1.08
C57BLKS/J m 5.4 0.995   5 0.445 0.184 4.2, 6.9 -0.08
CAST/EiJ m 3.54 1.24   5 0.556 0.351 1.8, 5.2 -1.03
CBA/J m 5.46 0.873   5 0.391 0.16 4.1, 6.3 -0.05
DBA/2J m 4.98 1.96   9 0.654 0.394 1.6, 8.6 -0.29
DDY/JclSidSeyFrkJ m 7.44 3.49   7 1.32 0.468 1.0, 12.4 0.96
FVB/NJ m 7.94 2.11   5 0.943 0.265 4.7, 9.6 1.22
KK/HlJ m 7.01 2.09   7 0.79 0.298 4.8, 9.8 0.74
MA/MyJ m 3.92 1.42   6 0.579 0.362 2.2, 6.4 -0.84
MOLF/EiJ m 4.68 1.63   5 0.727 0.347 2.6, 6.7 -0.45
MRL/MpJ m 3.82 1.96   5 0.878 0.514 2.5, 7.3 -0.89
MSM/MsJ m 5.98 1.35   5 0.605 0.226 4.1, 7.2 0.22
NOD/ShiLtJ m 4.98 1.34   5 0.6 0.27 3.8, 7.0 -0.29
NON/ShiLtJ m 4.27 1.93   7 0.731 0.453 1.8, 7.4 -0.66
NZL/LtJ m 9.87 5.72   7 2.16 0.58 2.7, 17.0 2.21
NZO/HlLtJ m 10.4 1.52   4 0.758 0.145 8.3, 11.8 2.48
NZW/LacJ m 4.2 0.632   5 0.283 0.151 3.3, 4.9 -0.69
PWK/PhJ m 5.74 1.53   5 0.682 0.266 3.4, 7.2 0.09
SJL/J m 7.45 0.79   4 0.395 0.106 6.8, 8.6 0.97
SM/J m 5.05 1.95   8 0.688 0.386 2.3, 7.3 -0.26


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 6.275 0.8025 7.8637 4.6863
A/J m 6.3 1.0151 8.3096 4.2904
AKR/J m 2.66 1.0151 4.6696 0.6504
BALB/cByJ m 2.65 1.135 4.8968 0.4032
BTBR T+ Itpr3tf/J m 6.2125 0.8025 7.8012 4.6238
C3H/HeJ m 4.775 1.135 7.0218 2.5282
C57BL/6J m 3.44 1.0151 5.4496 1.4304
C57BLKS/J m 5.4 1.0151 7.4096 3.3904
CAST/EiJ m 3.54 1.0151 5.5496 1.5304
CBA/J m 5.46 1.0151 7.4696 3.4504
DBA/2J m 4.9778 0.7566 6.4756 3.4799
DDY/JclSidSeyFrkJ m 7.4429 0.8579 9.1412 5.7445
FVB/NJ m 7.94 1.0151 9.9496 5.9304
KK/HlJ m 7.0143 0.8579 8.7127 5.3159
MA/MyJ m 3.9167 0.9267 5.7511 2.0822
MOLF/EiJ m 4.68 1.0151 6.6896 2.6704
MRL/MpJ m 3.82 1.0151 5.8296 1.8104
MSM/MsJ m 5.98 1.0151 7.9896 3.9704
NOD/ShiLtJ m 4.98 1.0151 6.9896 2.9704
NON/ShiLtJ m 4.2714 0.8579 5.9698 2.573
NZL/LtJ m 9.8714 0.8579 11.5698 8.173
NZO/HlLtJ m 10.45 1.135 12.6968 8.2032
NZW/LacJ m 4.2 1.0151 6.2096 2.1904
PWK/PhJ m 5.74 1.0151 7.7496 3.7304
SJL/J m 7.45 1.135 9.6968 5.2032
SM/J m 5.05 0.8025 6.6387 3.4613




  GWAS USING LINEAR MIXED MODELS