MPD: Project measures / variables set: Threadgill1 GSHratio

Project measures / variables set: Threadgill1 GSHratio

ID, description, units	MPD:19420 GSHratio ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] acetaminophen study
Measures	• control • post-Rx 300mg/kg
Data set, strains	Threadgill1 inbred w/CC7 36 strains sex: m age: 8-17wks
Procedure	metabolite quantification
Comparison	control group vs. treated group
Ontology mappings	VT:0000609 liver physiology trait VT:0010487 response to xenobiotic stimulus trait VT:0010516 blood glutathione amount MA:0000358 liver MP:0008872 abnormal physiological response to xenobiotic MP:0011601 abnormal glutathione peroxidase activity

Values Means Δ Means Z-scores

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Threadgill1 - ratio of reduced (GSH) to oxidized (GSSG) glutathione

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	33.446	33.446	0.0377	0.8463
strain	30	55731.1398	1857.7047	2.0967	0.0026
group:strain	30	19300.9269	643.3642	0.7262	0.8441
Residuals	122	108091.1163	885.9928

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill1	19420	metabolite quantification	acetaminophen	ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] control GSHratio_ctrl	inbred w/CC7	35	m	8-17wks
Threadgill1	19481	metabolite quantification	acetaminophen	ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] post-Rx 300mg/kg GSHratio_Rx300	inbred w/CC7	36	m	8-17wks