MPD: Project measures / variables set: Threadgill1 GSH

Project measures / variables set: Threadgill1 GSH

ID, description, units	MPD:19414 GSH reduced glutathione (GSH) [µmol/g] acetaminophen study
Measures	• control • post-Rx 300mg/kg
Data set, strains	Threadgill1 inbred w/CC7 36 strains sex: m age: 8-17wks
Procedure	metabolite quantification
Comparison	control group vs. treated group
Ontology mappings	VT:0000609 liver physiology trait VT:0010487 response to xenobiotic stimulus trait VT:0010516 blood glutathione amount MA:0000358 liver MP:0008872 abnormal physiological response to xenobiotic MP:0011601 abnormal glutathione peroxidase activity

Values Means Δ Means Z-scores

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Threadgill1 - reduced glutathione (GSH)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	233.6991	233.6991	137.192	< 0.0001
strain	30	186.9351	6.2312	3.658	< 0.0001
group:strain	30	75.6772	2.5226	1.4809	0.0709
Residuals	123	209.5238	1.7034

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill1	19414	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/g] control GSH_ctrl	inbred w/CC7	35	m	8-17wks
Threadgill1	19475	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/g] post-Rx 300mg/kg GSH_Rx300	inbred w/CC7	36	m	8-17wks