Project measure / variable:   GMC20   IgA_17

ID, description, units MPD:56904   IgA_17   immunoglobulin A (plasma IgA)   [µg/mL]  at age 16-17wks  
Data set, strains GMC20   inbred w/CC8   7 strains     sex: both     age: 16-17wks
Procedure immunoglobulin quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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GMC20 - immunoglobulin A (plasma IgA) at age 16-17wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested6 strains7 strains
Mean of the strain means477   µg/mL 493   µg/mL
Median of the strain means300   µg/mL 402   µg/mL
SD of the strain means± 431 ± 256
Coefficient of variation (CV)0.903 0.520
Min–max range of strain means216   –   1344   µg/mL 243   –   855   µg/mL
Mean sample size per strain3.3   mice 3.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 17313.7935 17313.7935 0.2165 0.6452
strain 4 3578006.3577 894501.5894 11.1852 < 0.0001
sex:strain 4 958219.451 239554.8628 2.9955 0.0348
Residuals 29 2319180.3606 79971.7366


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 216.0 80.9   3 46.7 0.374 125.0, 281.0 -0.61
129S1/SvImJ m 556.0 445.0   4 222.0 0.8 169.0, 1026.0 0.25
A/J f 318.0 36.7   4 18.3 0.115 264.0, 341.0 -0.37
A/J m 402.0 80.1   4 40.0 0.199 282.0, 446.0 -0.35
C57BL/6J f 432.0 117.0   4 58.4 0.27 313.0, 534.0 -0.1
C57BL/6J m 814.0 223.0   4 112.0 0.274 587.0, 1072.0 1.25
NOD/ShiLtJ f 1344.0 681.0   4 341.0 0.507 861.0, 2323.0 2.01
NOD/ShiLtJ m 855.0 89.5   4 44.8 0.105 772.0, 979.0 1.41
NZO/HlLtJ f 270.0 129.0   4 64.3 0.476 146.0, 450.0 -0.48
NZO/HlLtJ m 243.0 105.0   4 52.5 0.433 108.0, 331.0 -0.97
PWK/PhJ m 325.0 0.0   1   0.0 0.0 325.0, 325.0 -0.65
WSB/EiJ f 282.0 0.0   1   0.0 0.0 282.0, 282.0 -0.45
WSB/EiJ m 254.0 71.5   2   50.6 0.281 204.0, 305.0 -0.93


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 216.2767 163.2705 550.2023 -117.6489
129S1/SvImJ m 556.0125 141.3964 845.2006 266.8244
A/J f 317.9375 141.3964 607.1256 28.7494
A/J m 401.65 141.3964 690.8381 112.4619
C57BL/6J f 432.1375 141.3964 721.3256 142.9494
C57BL/6J m 814.0375 141.3964 1103.2256 524.8494
NOD/ShiLtJ f 1343.5425 141.3964 1632.7306 1054.3544
NOD/ShiLtJ m 855.13 141.3964 1144.3181 565.9419
NZO/HlLtJ f 270.15 141.3964 559.3381 -19.0381
NZO/HlLtJ m 242.86 141.3964 532.0481 -46.3281


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 386.1446 107.9933 607.0156 165.2736
A/J both 359.7938 99.9823 564.2806 155.3069
C57BL/6J both 623.0875 99.9823 827.5743 418.6007
NOD/ShiLtJ both 1099.3363 99.9823 1303.8231 894.8494
NZO/HlLtJ both 256.505 99.9823 460.9918 52.0182




  GWAS USING LINEAR MIXED MODELS