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Project measure / variable:   HMDPpheno7   NAD

ID, description, units MPD:50231   NAD   liver nicotinamide adenine dinucleotide (NAD+) (16h fast), relative abundance    
Data set, strains HMDPpheno7   HMDP   106 strains     sex: m     age: 16wks
Procedure metabolite quantification
Ontology mappings


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  STRAIN COMPARISON PLOT
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HMDPpheno7 - liver nicotinamide adenine dinucleotide (NAD+) (16h fast), relative abundance



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested106 strains
Mean of the strain means396485   None
Median of the strain means394422   None
SD of the strain means± 56964
Coefficient of variation (CV)0.144
Min–max range of strain means228611   –   509822   None
Mean sample size per strain1.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 21 131892997791.13 6280618942.4348 2.7324 0.0044
Residuals 34 78151704063.8901 2298579531.2909


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129X1/SvJ m 389150.0 0.0   1   0.0 0.0 389150.0, 389150.0 -0.13
A/J m 375055.0 36816.0   2   26033.0 0.0982 349023.0, 401088.0 -0.38
AKR/J m 388909.0 0.0   1   0.0 0.0 388909.0, 388909.0 -0.13
AXB10/PgnJ m 459774.0 0.0   1   0.0 0.0 459774.0, 459774.0 1.11
AXB12/PgnJ m 385774.0 0.0   1   0.0 0.0 385774.0, 385774.0 -0.19
AXB13/PgnJ m 448284.0 0.0   1   0.0 0.0 448284.0, 448284.0 0.91
AXB15/PgnJ m 376622.0 0.0   1   0.0 0.0 376622.0, 376622.0 -0.35
AXB19a/PgnJ m 447212.0 0.0   1   0.0 0.0 447212.0, 447212.0 0.89
AXB19b/PgnJ m 460455.0 50202.0   2   35498.0 0.109 424956.0, 495953.0 1.12
AXB19/PgnJ m 421757.0 0.0   1   0.0 0.0 421757.0, 421757.0 0.44
AXB1/PgnJ m 387655.0 0.0   1   0.0 0.0 387655.0, 387655.0 -0.16
AXB23/PgnJ m 447239.0 0.0   1   0.0 0.0 447239.0, 447239.0 0.89
AXB24/PgnJ m 321911.0 64009.0   2   45261.0 0.199 276650.0, 367172.0 -1.31
AXB2/PgnJ m 369756.0 0.0   1   0.0 0.0 369756.0, 369756.0 -0.47
AXB4/PgnJ m 481299.0 0.0   1   0.0 0.0 481299.0, 481299.0 1.49
AXB5/PgnJ m 348807.0 0.0   1   0.0 0.0 348807.0, 348807.0 -0.84
AXB6/PgnJ m 430498.0 0.0   1   0.0 0.0 430498.0, 430498.0 0.6
AXB8/PgnJ m 408430.0 0.0   1   0.0 0.0 408430.0, 408430.0 0.21
BALB/cJ m 417886.0 19050.0   3 10999.0 0.0456 396787.0, 433823.0 0.38
BTBR T+ Itpr3tf/J m 364780.0 0.0   1   0.0 0.0 364780.0, 364780.0 -0.56
BUB/BnJ m 387798.0 0.0   1   0.0 0.0 387798.0, 387798.0 -0.15
BXA11/PgnJ m 421048.0 0.0   1   0.0 0.0 421048.0, 421048.0 0.43
BXA12/PgnJ m 287798.0 0.0   1   0.0 0.0 287798.0, 287798.0 -1.91
BXA13/PgnJ m 485568.0 0.0   1   0.0 0.0 485568.0, 485568.0 1.56
BXA14/PgnJ m 228611.0 0.0   1   0.0 0.0 228611.0, 228611.0 -2.95
BXA16/PgnJ m 420300.0 12979.0   2   9178.0 0.0309 411123.0, 429478.0 0.42
BXA1/PgnJ m 454850.0 0.0   1   0.0 0.0 454850.0, 454850.0 1.02
BXA24/PgnJ m 387098.0 0.0   1   0.0 0.0 387098.0, 387098.0 -0.16
BXA25/PgnJ m 347200.0 0.0   1   0.0 0.0 347200.0, 347200.0 -0.87
BXA26/PgnJ m 392337.0 0.0   1   0.0 0.0 392337.0, 392337.0 -0.07
BXA2/PgnJ m 328118.0 0.0   1   0.0 0.0 328118.0, 328118.0 -1.2
BXA4/PgnJ m 249155.0 0.0   1   0.0 0.0 249155.0, 249155.0 -2.59
BXA7/PgnJ m 344737.0 0.0   1   0.0 0.0 344737.0, 344737.0 -0.91
BXA8/PgnJ m 454474.0 0.0   1   0.0 0.0 454474.0, 454474.0 1.02
BXD11/TyJ m 387362.0 0.0   1   0.0 0.0 387362.0, 387362.0 -0.16
BXD12/TyJ m 379460.0 0.0   1   0.0 0.0 379460.0, 379460.0 -0.3
BXD13/TyJ m 366120.0 0.0   1   0.0 0.0 366120.0, 366120.0 -0.53
BXD14/TyJ m 509822.0 0.0   1   0.0 0.0 509822.0, 509822.0 1.99
BXD15/TyJ m 439738.0 0.0   1   0.0 0.0 439738.0, 439738.0 0.76
BXD18/TyJ m 321590.0 0.0   1   0.0 0.0 321590.0, 321590.0 -1.31
BXD19/TyJ m 445018.0 612.0   2   432.0 0.00137 444585.0, 445450.0 0.85
BXD1/TyJ m 489445.0 0.0   1   0.0 0.0 489445.0, 489445.0 1.63
BXD20/TyJ m 332649.0 0.0   1   0.0 0.0 332649.0, 332649.0 -1.12
BXD21/TyJ m 358929.0 0.0   1   0.0 0.0 358929.0, 358929.0 -0.66
BXD22/TyJ m 384228.0 0.0   1   0.0 0.0 384228.0, 384228.0 -0.22
BXD24/TyJ m 438593.0 0.0   1   0.0 0.0 438593.0, 438593.0 0.74
BXD24/TyJ-Cep290rd16/J m 415736.0 0.0   1   0.0 0.0 415736.0, 415736.0 0.34
BXD28/TyJ m 340837.0 257.0   2   182.0 0.000755 340655.0, 341019.0 -0.98
BXD29-Tlr4lps-2J/J m 474022.0 0.0   1   0.0 0.0 474022.0, 474022.0 1.36
BXD2/TyJ m 404478.0 0.0   1   0.0 0.0 404478.0, 404478.0 0.14
BXD32/TyJ m 413682.0 0.0   1   0.0 0.0 413682.0, 413682.0 0.3
BXD33/TyJ m 475541.0 0.0   1   0.0 0.0 475541.0, 475541.0 1.39
BXD34/TyJ m 365908.0 0.0   1   0.0 0.0 365908.0, 365908.0 -0.54
BXD36/TyJ m 506284.0 0.0   1   0.0 0.0 506284.0, 506284.0 1.93
BXD38/TyJ m 367665.0 0.0   1   0.0 0.0 367665.0, 367665.0 -0.51
BXD39/TyJ m 301688.0 0.0   1   0.0 0.0 301688.0, 301688.0 -1.66
BXD40/TyJ m 424918.0 0.0   1   0.0 0.0 424918.0, 424918.0 0.5
BXD42/TyJ m 323869.0 0.0   1   0.0 0.0 323869.0, 323869.0 -1.27
BXD5/TyJ m 396507.0 0.0   1   0.0 0.0 396507.0, 396507.0 0.0
BXD6/TyJ m 366621.0 0.0   1   0.0 0.0 366621.0, 366621.0 -0.52
BXD8/TyJ m 322255.0 0.0   1   0.0 0.0 322255.0, 322255.0 -1.3
BXD9/TyJ m 426774.0 0.0   1   0.0 0.0 426774.0, 426774.0 0.53
BXH10/TyJ m 491540.0 0.0   1   0.0 0.0 491540.0, 491540.0 1.67
BXH19/TyJ m 325778.0 0.0   1   0.0 0.0 325778.0, 325778.0 -1.24
BXH20/KccJ m 425598.0 0.0   1   0.0 0.0 425598.0, 425598.0 0.51
BXH22/KccJ m 439281.0 0.0   1   0.0 0.0 439281.0, 439281.0 0.75
BXH2/TyJ m 377107.0 0.0   1   0.0 0.0 377107.0, 377107.0 -0.34
BXH4/TyJ m 367401.0 59150.0   2   41825.0 0.161 325576.0, 409226.0 -0.51
BXH6/TyJ m 444812.0 0.0   1   0.0 0.0 444812.0, 444812.0 0.85
BXH7/TyJ m 369906.0 0.0   1   0.0 0.0 369906.0, 369906.0 -0.47
BXH8/TyJ m 336464.0 0.0   1   0.0 0.0 336464.0, 336464.0 -1.05
BXH9/TyJ m 401368.0 0.0   1   0.0 0.0 401368.0, 401368.0 0.09
C3H/HeJ m 447565.0 15362.0   2   10862.0 0.0343 436702.0, 458427.0 0.9
C57BL/6J m 363846.0 28644.0   5 12810.0 0.0787 332377.0, 403192.0 -0.57
C57L/J m 427929.0 0.0   1   0.0 0.0 427929.0, 427929.0 0.55
C58/J m 371246.0 0.0   1   0.0 0.0 371246.0, 371246.0 -0.44
CAST/EiJ m 392141.0 0.0   1   0.0 0.0 392141.0, 392141.0 -0.08
CBA/J m 375926.0 0.0   1   0.0 0.0 375926.0, 375926.0 -0.36
CE/J m 360638.0 0.0   1   0.0 0.0 360638.0, 360638.0 -0.63
CXB11/HiAJ m 472294.0 129044.0   2   91248.0 0.273 381046.0, 563542.0 1.33
CXB12/HiAJ m 360921.0 10385.0   2   7344.0 0.0288 353577.0, 368264.0 -0.62
CXB13/HiAJ m 468269.0 104836.0   3 60527.0 0.224 356094.0, 563766.0 1.26
CXB1/ByJ m 483239.0 87763.0   3 50670.0 0.182 429753.0, 584526.0 1.52
CXB2/ByJ m 437508.0 18600.0   3 10739.0 0.0425 424315.0, 458782.0 0.72
CXB3/ByJ m 320591.0 13263.0   2   9378.0 0.0414 311212.0, 329969.0 -1.33
CXB4/ByJ m 404399.0 15559.0   2   11002.0 0.0385 393397.0, 415401.0 0.14
CXB6/ByJ m 334703.0 16354.0   3 9442.0 0.0489 315871.0, 345322.0 -1.08
CXB7/ByJ m 374965.0 43237.0   2   30573.0 0.115 344391.0, 405538.0 -0.38
CXB8/HiAJ m 404660.0 4539.0   3 2621.0 0.0112 401780.0, 409893.0 0.14
CXB9/HiAJ m 358037.0 37622.0   3 21721.0 0.105 334197.0, 401408.0 -0.67
DBA/2J m 412057.0 24051.0   4 12025.0 0.0584 393709.0, 445063.0 0.27
FVB/NJ m 334091.0 0.0   1   0.0 0.0 334091.0, 334091.0 -1.1
I/LnJ m 480954.0 0.0   1   0.0 0.0 480954.0, 480954.0 1.48
KK/HlJ m 349808.0 0.0   1   0.0 0.0 349808.0, 349808.0 -0.82
LG/J m 478297.0 0.0   1   0.0 0.0 478297.0, 478297.0 1.44
LP/J m 417590.0 0.0   1   0.0 0.0 417590.0, 417590.0 0.37
MA/MyJ m 439643.0 0.0   1   0.0 0.0 439643.0, 439643.0 0.76
NOD/ShiLtJ m 366353.0 0.0   1   0.0 0.0 366353.0, 366353.0 -0.53
NON/ShiLtJ m 412391.0 0.0   1   0.0 0.0 412391.0, 412391.0 0.28
NZW/LacJ m 306020.0 0.0   1   0.0 0.0 306020.0, 306020.0 -1.59
PL/J m 440033.0 0.0   1   0.0 0.0 440033.0, 440033.0 0.76
RIIIS/J m 459545.0 0.0   1   0.0 0.0 459545.0, 459545.0 1.11
SEA/GnJ m 414452.0 0.0   1   0.0 0.0 414452.0, 414452.0 0.32
SJL/J m 250453.0 0.0   1   0.0 0.0 250453.0, 250453.0 -2.56
SM/J m 419101.0 0.0   1   0.0 0.0 419101.0, 419101.0 0.4
SWR/J m 408402.0 0.0   1   0.0 0.0 408402.0, 408402.0 0.21


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J m 375055.35 33901.1765 443950.8297 306159.8703
AXB19b/PgnJ m 460454.6 33901.1765 529350.0797 391559.1203
AXB24/PgnJ m 321911.35 33901.1765 390806.8297 253015.8703
BALB/cJ m 417886.4 27680.1947 474139.3236 361633.4764
BXA16/PgnJ m 420300.45 33901.1765 489195.9297 351404.9703
BXD19/TyJ m 445017.7 33901.1765 513913.1797 376122.2203
BXD28/TyJ m 340837.05 33901.1765 409732.5297 271941.5703
BXH4/TyJ m 367401.35 33901.1765 436296.8297 298505.8703
C3H/HeJ m 447564.8 33901.1765 516460.2797 378669.3203
C57BL/6J m 363845.7 21440.9866 407419.0273 320272.3727
CXB11/HiAJ m 472293.95 33901.1765 541189.4297 403398.4703
CXB12/HiAJ m 360920.55 33901.1765 429816.0297 292025.0703
CXB13/HiAJ m 468268.7333 27680.1947 524521.657 412015.8097
CXB1/ByJ m 483238.9667 27680.1947 539491.8903 426986.043
CXB2/ByJ m 437507.8333 27680.1947 493760.757 381254.9097
CXB3/ByJ m 320590.6 33901.1765 389486.0797 251695.1203
CXB4/ByJ m 404398.9 33901.1765 473294.3797 335503.4203
CXB6/ByJ m 334703.3333 27680.1947 390956.257 278450.4097
CXB7/ByJ m 374964.55 33901.1765 443860.0297 306069.0703
CXB8/HiAJ m 404660.3333 27680.1947 460913.257 348407.4097
CXB9/HiAJ m 358036.9667 27680.1947 414289.8903 301784.043
DBA/2J m 412057.45 23971.7518 460773.9109 363340.9891




  GWAS USING LINEAR MIXED MODELS