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Project measure / variable:   Berndt2   resp_flow_slope

ID, description, units MPD:35158   resp_flow_slope   respiratory flow rate   [mL/kg/s]  response index  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - respiratory flow rate response index



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means0.166   mL/kg/s 0.196   mL/kg/s
Median of the strain means0.137   mL/kg/s 0.173   mL/kg/s
SD of the strain means± 0.219 ± 0.219
Coefficient of variation (CV)1.32 1.11
Min–max range of strain means-0.252   –   0.593   mL/kg/s -0.240   –   0.541   mL/kg/s
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.1346 0.1346 1.9963 0.1584
strain 28 19.2146 0.6862 10.1768 < 0.0001
sex:strain 28 2.8456 0.1016 1.5071 0.0491
Residuals 412 27.7816 0.0674


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.555 0.343   8 0.121 0.618 -0.034, 0.918 1.78
129S1/SvImJ m 0.512 0.329   8 0.116 0.644 0.081, 0.939 1.44
A/J f -0.251 0.13   8 0.0461 -0.521 -0.408, -0.055 -1.91
A/J m -0.24 0.122   8 0.0432 -0.509 -0.43, -0.018 -1.99
AKR/J f 0.167 0.131   8 0.0464 0.785 -0.044, 0.397 0.0
AKR/J m 0.541 0.24   8 0.0847 0.443 0.096, 0.827 1.57
BALB/cByJ f 0.102 0.178   8 0.0629 1.74 -0.111, 0.446 -0.29
BALB/cByJ m 0.135 0.119   8 0.0419 0.876 -0.052, 0.293 -0.28
BALB/cJ f -0.0045 0.12   10 0.0381 -26.8 -0.231, 0.175 -0.78
BALB/cJ m 0.0327 0.176   10 0.0556 5.38 -0.335, 0.3 -0.75
BTBR T+ Itpr3tf/J f 0.0798 0.311   8 0.11 3.9 -0.284, 0.72 -0.4
BTBR T+ Itpr3tf/J m -0.192 0.132   8 0.0467 -0.688 -0.355, 0.042 -1.77
BUB/BnJ f 0.194 0.282   7 0.106 1.45 -0.148, 0.704 0.13
BUB/BnJ m 0.219 0.281   8 0.0994 1.28 -0.098, 0.53 0.1
C3H/HeJ f 0.112 0.317   8 0.112 2.83 -0.336, 0.454 -0.25
C3H/HeJ m 0.0624 0.309   8 0.109 4.95 -0.319, 0.547 -0.61
C57BL/10J f 0.326 0.155   8 0.0546 0.474 0.117, 0.514 0.73
C57BL/10J m 0.309 0.127   7 0.048 0.411 0.078, 0.484 0.51
C57BL/6J f 0.408 0.212   7 0.0802 0.521 0.116, 0.671 1.11
C57BL/6J m 0.539 0.262   13 0.0727 0.486 0.239, 1.0 1.56
C57BLKS/J f 0.375 0.329   11 0.0992 0.877 -0.167, 0.904 0.95
C57BLKS/J m 0.436 0.304   8 0.107 0.697 0.022, 0.959 1.09
C57BR/cdJ f 0.377 0.393   6 0.16 1.04 -0.316, 0.718 0.96
C57BR/cdJ m 0.408 0.248   8 0.0876 0.607 0.032, 0.704 0.97
C57L/J f 0.377 0.0462   8 0.0163 0.122 0.323, 0.447 0.96
C57L/J m 0.383 0.142   8 0.0502 0.371 0.098, 0.55 0.85
CBA/J f 0.466 0.137   8 0.0484 0.293 0.274, 0.694 1.37
CBA/J m 0.477 0.151   8 0.0534 0.316 0.245, 0.629 1.28
CE/J f 0.137 0.377   8 0.133 2.74 -0.181, 0.967 -0.13
CE/J m 0.0372 0.138   9 0.046 3.7 -0.163, 0.255 -0.73
DBA/1J f 0.277 0.172   10 0.0545 0.621 -0.033, 0.526 0.51
DBA/1J m -0.032 0.137   8 0.0483 -4.27 -0.219, 0.125 -1.04
DBA/2J f 0.174 0.179   8 0.0632 1.03 -0.021, 0.527 0.04
DBA/2J m 0.226 0.234   10 0.0739 1.04 0.024, 0.742 0.14
FVB/NJ f 0.101 0.486   8 0.172 4.81 -0.617, 0.729 -0.3
FVB/NJ m 0.345 0.388   7 0.147 1.13 -0.192, 0.747 0.68
I/LnJ f 0.0629 0.256   7 0.0966 4.07 -0.241, 0.379 -0.47
I/LnJ m 0.161 0.432   5 0.193 2.68 -0.372, 0.585 -0.16
KK/HlJ f 0.333 0.154   8 0.0546 0.464 0.128, 0.524 0.76
KK/HlJ m 0.373 0.244   6 0.0997 0.654 0.096, 0.775 0.81
LP/J f -0.123 0.413   8 0.146 -3.36 -0.94, 0.481 -1.32
LP/J m 0.173 0.285   8 0.101 1.65 -0.25, 0.743 -0.11
NOD/ShiLtJ f 0.593 0.221   8 0.0783 0.374 0.203, 0.894 1.95
NOD/ShiLtJ m 0.395 0.404   8 0.143 1.02 -0.359, 0.734 0.91
NON/ShiLtJ f -0.0876 0.272   8 0.0962 -3.1 -0.547, 0.391 -1.16
NON/ShiLtJ m -0.098 0.215   8 0.0759 -2.19 -0.365, 0.323 -1.34
NZW/LacJ f 0.032 0.139   8 0.0493 4.36 -0.213, 0.262 -0.61
NZW/LacJ m 0.119 0.196   8 0.0692 1.64 -0.18, 0.387 -0.35
PL/J f -0.252 0.248   8 0.0878 -0.985 -0.57, 0.099 -1.91
PL/J m -0.0619 0.434   8 0.153 -7.01 -0.514, 0.753 -1.18
RIIIS/J f 0.234 0.0997   8 0.0353 0.425 0.087, 0.366 0.31
RIIIS/J m 0.0279 0.165   8 0.0584 5.93 -0.168, 0.273 -0.77
SJL/J f -0.0191 0.444   8 0.157 -23.2 -0.565, 0.579 -0.85
SJL/J m 0.0764 0.378   8 0.134 4.95 -0.51, 0.58 -0.55
SM/J f 0.116 0.175   8 0.0619 1.51 -0.087, 0.371 -0.23
SM/J m 0.0924 0.274   8 0.097 2.97 -0.443, 0.47 -0.47
SWR/J f -0.0398 0.293   8 0.104 -7.37 -0.424, 0.392 -0.94
SWR/J m 0.239 0.137   9 0.0457 0.573 0.001, 0.454 0.19


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.5553 0.0918 0.7357 0.3748
129S1/SvImJ m 0.5116 0.0918 0.6921 0.3312
A/J f -0.2505 0.0918 -0.07 -0.431
A/J m -0.2399 0.0918 -0.0594 -0.4203
AKR/J f 0.1672 0.0918 0.3477 -0.0132
AKR/J m 0.541 0.0918 0.7215 0.3605
BALB/cByJ f 0.1024 0.0918 0.2828 -0.0781
BALB/cByJ m 0.1355 0.0918 0.316 -0.045
BALB/cJ f -0.0045 0.0821 0.1569 -0.1659
BALB/cJ m 0.0327 0.0821 0.1941 -0.1287
BTBR T+ Itpr3tf/J f 0.0798 0.0918 0.2602 -0.1007
BTBR T+ Itpr3tf/J m -0.1919 0.0918 -0.0114 -0.3723
BUB/BnJ f 0.1943 0.0981 0.3872 0.0014
BUB/BnJ m 0.2193 0.0918 0.3997 0.0388
C3H/HeJ f 0.112 0.0918 0.2925 -0.0685
C3H/HeJ m 0.0624 0.0918 0.2428 -0.1181
C57BL/10J f 0.3258 0.0918 0.5062 0.1453
C57BL/10J m 0.3094 0.0981 0.5024 0.1165
C57BL/6J f 0.4077 0.0981 0.6006 0.2148
C57BL/6J m 0.5388 0.072 0.6803 0.3972
C57BLKS/J f 0.3749 0.0783 0.5288 0.221
C57BLKS/J m 0.4356 0.0918 0.6161 0.2552
C57BR/cdJ f 0.3773 0.106 0.5857 0.1689
C57BR/cdJ m 0.4078 0.0918 0.5882 0.2273
C57L/J f 0.3774 0.0918 0.5578 0.1969
C57L/J m 0.3833 0.0918 0.5637 0.2028
CBA/J f 0.4664 0.0918 0.6468 0.2859
CBA/J m 0.4771 0.0918 0.6576 0.2967
CE/J f 0.1374 0.0918 0.3178 -0.0431
CE/J m 0.0372 0.0866 0.2074 -0.1329
DBA/1J f 0.2774 0.0821 0.4388 0.116
DBA/1J m -0.032 0.0918 0.1485 -0.2125
DBA/2J f 0.1735 0.0918 0.354 -0.007
DBA/2J m 0.2256 0.0821 0.387 0.0642
FVB/NJ f 0.1011 0.0918 0.2816 -0.0793
FVB/NJ m 0.3447 0.0981 0.5376 0.1518
I/LnJ f 0.0629 0.0981 0.2558 -0.1301
I/LnJ m 0.161 0.1161 0.3893 -0.0673
KK/HlJ f 0.333 0.0918 0.5135 0.1525
KK/HlJ m 0.3735 0.106 0.5819 0.1651
LP/J f -0.1228 0.0918 0.0577 -0.3032
LP/J m 0.1729 0.0918 0.3533 -0.0076
NOD/ShiLtJ f 0.5926 0.0918 0.7731 0.4122
NOD/ShiLtJ m 0.3946 0.0918 0.5751 0.2142
NON/ShiLtJ f -0.0876 0.0918 0.0928 -0.2681
NON/ShiLtJ m -0.098 0.0918 0.0825 -0.2785
NZW/LacJ f 0.032 0.0918 0.2125 -0.1485
NZW/LacJ m 0.1193 0.0918 0.2997 -0.0612
PL/J f -0.2521 0.0918 -0.0717 -0.4326
PL/J m -0.0619 0.0918 0.1186 -0.2423
RIIIS/J f 0.2344 0.0918 0.4148 0.0539
RIIIS/J m 0.0279 0.0918 0.2083 -0.1526
SJL/J f -0.0191 0.0918 0.1613 -0.1996
SJL/J m 0.0764 0.0918 0.2568 -0.1041
SM/J f 0.1161 0.0918 0.2966 -0.0643
SM/J m 0.0924 0.0918 0.2728 -0.0881
SWR/J f -0.0398 0.0918 0.1407 -0.2202
SWR/J m 0.2392 0.0866 0.4094 0.0691


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.5334 0.0649 0.6611 0.4058
A/J both -0.2452 0.0649 -0.1176 -0.3728
AKR/J both 0.3541 0.0649 0.4817 0.2265
BALB/cByJ both 0.1189 0.0649 0.2466 -0.0087
BALB/cJ both 0.0141 0.0581 0.1282 -0.1
BTBR T+ Itpr3tf/J both -0.0561 0.0649 0.0716 -0.1837
BUB/BnJ both 0.2068 0.0672 0.3389 0.0747
C3H/HeJ both 0.0872 0.0649 0.2148 -0.0404
C57BL/10J both 0.3176 0.0672 0.4497 0.1855
C57BL/6J both 0.4732 0.0609 0.5929 0.3536
C57BLKS/J both 0.4053 0.0603 0.5239 0.2867
C57BR/cdJ both 0.3925 0.0701 0.5304 0.2547
C57L/J both 0.3803 0.0649 0.5079 0.2527
CBA/J both 0.4717 0.0649 0.5994 0.3441
CE/J both 0.0873 0.0631 0.2113 -0.0367
DBA/1J both 0.1227 0.0616 0.2438 0.0016
DBA/2J both 0.1996 0.0616 0.3206 0.0785
FVB/NJ both 0.2229 0.0672 0.355 0.0908
I/LnJ both 0.1119 0.076 0.2614 -0.0375
KK/HlJ both 0.3532 0.0701 0.4911 0.2154
LP/J both 0.0251 0.0649 0.1527 -0.1026
NOD/ShiLtJ both 0.4936 0.0649 0.6212 0.366
NON/ShiLtJ both -0.0928 0.0649 0.0348 -0.2204
NZW/LacJ both 0.0756 0.0649 0.2032 -0.052
PL/J both -0.157 0.0649 -0.0294 -0.2846
RIIIS/J both 0.1311 0.0649 0.2587 0.0035
SJL/J both 0.0286 0.0649 0.1562 -0.099
SM/J both 0.1043 0.0649 0.2319 -0.0234
SWR/J both 0.0997 0.0631 0.2238 -0.0243




  GWAS USING LINEAR MIXED MODELS