Project measure / variable:   Berndt2   min_vent_saline

ID, description, units MPD:35101   min_vent_saline   minute ventilation   [mL/min]  saline  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - minute ventilation saline



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means60.7   mL/min 64.7   mL/min
Median of the strain means58.8   mL/min 63.5   mL/min
SD of the strain means± 15.0 ± 16.1
Coefficient of variation (CV)0.247 0.249
Min–max range of strain means35.0   –   98.3   mL/min 39.6   –   102   mL/min
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2560.1176 2560.1176 6.0311 0.0145
strain 28 103991.1137 3713.9683 8.7494 < 0.0001
sex:strain 28 11528.8993 411.7464 0.97 0.5116
Residuals 412 174886.9524 424.4829


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 46.8 10.8   8 3.8 0.23 26.1, 60.0 -0.93
129S1/SvImJ m 50.2 11.9   8 4.22 0.238 31.9, 67.8 -0.9
A/J f 62.5 10.4   8 3.67 0.166 48.2, 74.9 0.12
A/J m 67.6 16.1   8 5.69 0.238 46.8, 94.9 0.18
AKR/J f 59.4 18.5   8 6.54 0.312 38.1, 95.5 -0.09
AKR/J m 52.5 14.4   8 5.08 0.274 32.6, 75.4 -0.76
BALB/cByJ f 74.7 16.6   8 5.89 0.223 43.7, 94.2 0.93
BALB/cByJ m 84.7 23.5   8 8.3 0.277 58.4, 136.0 1.24
BALB/cJ f 98.3 44.9   10 14.2 0.457 41.3, 200.0 2.5
BALB/cJ m 95.3 26.0   10 8.21 0.272 52.1, 135.0 1.89
BTBR T+ Itpr3tf/J f 85.1 21.3   8 7.53 0.25 51.2, 124.0 1.63
BTBR T+ Itpr3tf/J m 102.0 22.0   8 7.76 0.214 77.8, 132.0 2.31
BUB/BnJ f 74.2 32.8   7 12.4 0.442 39.5, 124.0 0.9
BUB/BnJ m 69.8 17.1   8 6.06 0.246 48.9, 96.2 0.31
C3H/HeJ f 57.6 14.8   8 5.25 0.258 38.1, 87.0 -0.21
C3H/HeJ m 49.5 11.7   8 4.14 0.237 36.3, 68.1 -0.94
C57BL/10J f 77.8 35.2   8 12.5 0.453 55.4, 163.0 1.14
C57BL/10J m 82.6 24.7   7 9.35 0.3 55.6, 132.0 1.11
C57BL/6J f 70.8 26.6   7 10.0 0.375 48.8, 112.0 0.67
C57BL/6J m 86.3 36.9   13 10.2 0.428 47.1, 152.0 1.34
C57BLKS/J f 64.7 20.3   11 6.13 0.314 36.0, 102.0 0.27
C57BLKS/J m 62.9 14.7   8 5.2 0.234 44.7, 85.2 -0.11
C57BR/cdJ f 78.1 44.3   6 18.1 0.567 36.6, 161.0 1.16
C57BR/cdJ m 69.5 14.5   8 5.14 0.209 55.3, 93.7 0.29
C57L/J f 65.8 9.85   8 3.48 0.15 52.3, 77.4 0.34
C57L/J m 69.5 20.8   8 7.34 0.299 42.4, 111.0 0.29
CBA/J f 49.5 9.77   8 3.46 0.197 36.5, 61.6 -0.75
CBA/J m 62.2 16.2   8 5.71 0.26 41.2, 86.4 -0.16
CE/J f 76.9 33.5   8 11.8 0.436 36.2, 148.0 1.08
CE/J m 70.1 11.0   9 3.67 0.157 56.4, 93.1 0.33
DBA/1J f 46.5 13.3   10 4.19 0.285 21.4, 62.6 -0.95
DBA/1J m 47.3 12.3   8 4.34 0.259 30.1, 63.1 -1.08
DBA/2J f 58.8 12.1   8 4.28 0.206 47.6, 82.6 -0.13
DBA/2J m 68.8 15.4   10 4.88 0.224 47.9, 98.9 0.25
FVB/NJ f 49.1 22.6   8 7.99 0.46 31.6, 95.5 -0.77
FVB/NJ m 71.4 32.1   7 12.1 0.45 34.6, 130.0 0.41
I/LnJ f 51.8 11.9   7 4.51 0.23 36.3, 70.4 -0.59
I/LnJ m 59.1 5.54   5 2.48 0.0937 54.3, 67.3 -0.35
KK/HlJ f 75.0 30.9   8 10.9 0.413 49.0, 126.0 0.95
KK/HlJ m 63.5 13.9   6 5.69 0.219 49.7, 90.3 -0.08
LP/J f 35.0 9.01   8 3.18 0.258 21.7, 50.2 -1.71
LP/J m 54.1 16.3   8 5.77 0.302 38.6, 79.6 -0.66
NOD/ShiLtJ f 43.3 10.9   8 3.86 0.252 30.9, 64.0 -1.16
NOD/ShiLtJ m 41.9 9.11   8 3.22 0.218 31.5, 57.5 -1.42
NON/ShiLtJ f 54.4 17.3   8 6.13 0.319 29.0, 78.2 -0.42
NON/ShiLtJ m 82.4 22.5   8 7.96 0.273 59.7, 132.0 1.09
NZW/LacJ f 46.2 10.6   8 3.74 0.229 34.1, 61.7 -0.97
NZW/LacJ m 42.7 7.27   8 2.57 0.17 29.7, 51.2 -1.37
PL/J f 53.6 16.5   8 5.82 0.307 31.4, 84.9 -0.47
PL/J m 57.1 21.2   8 7.48 0.371 41.6, 105.0 -0.47
RIIIS/J f 61.5 26.7   8 9.44 0.435 38.9, 118.0 0.05
RIIIS/J m 57.5 7.97   8 2.82 0.139 44.7, 71.1 -0.45
SJL/J f 45.7 6.21   8 2.19 0.136 33.8, 52.5 -1.0
SJL/J m 39.6 12.7   8 4.48 0.32 25.7, 56.2 -1.56
SM/J f 58.3 9.8   8 3.46 0.168 45.1, 73.5 -0.16
SM/J m 73.3 26.8   8 9.49 0.366 44.3, 121.0 0.53
SWR/J f 39.1 11.0   8 3.88 0.281 28.9, 55.8 -1.44
SWR/J m 44.1 10.3   9 3.43 0.234 26.9, 57.6 -1.28


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 46.7875 7.2843 61.1064 32.4686
129S1/SvImJ m 50.175 7.2843 64.4939 35.8561
A/J f 62.5375 7.2843 76.8564 48.2186
A/J m 67.5625 7.2843 81.8814 53.2436
AKR/J f 59.4125 7.2843 73.7314 45.0936
AKR/J m 52.5125 7.2843 66.8314 38.1936
BALB/cByJ f 74.675 7.2843 88.9939 60.3561
BALB/cByJ m 84.7125 7.2843 99.0314 70.3936
BALB/cJ f 98.3 6.5152 111.1072 85.4928
BALB/cJ m 95.35 6.5152 108.1572 82.5428
BTBR T+ Itpr3tf/J f 85.05 7.2843 99.3689 70.7311
BTBR T+ Itpr3tf/J m 102.5 7.2843 116.8189 88.1811
BUB/BnJ f 74.2143 7.7872 89.5219 58.9067
BUB/BnJ m 69.8375 7.2843 84.1564 55.5186
C3H/HeJ f 57.5875 7.2843 71.9064 43.2686
C3H/HeJ m 49.475 7.2843 63.7939 35.1561
C57BL/10J f 77.8125 7.2843 92.1314 63.4936
C57BL/10J m 82.5571 7.7872 97.8647 67.2496
C57BL/6J f 70.8429 7.7872 86.1504 55.5353
C57BL/6J m 86.2846 5.7142 97.5173 75.0519
C57BLKS/J f 64.6909 6.212 76.9021 52.4797
C57BLKS/J m 62.9 7.2843 77.2189 48.5811
C57BR/cdJ f 78.1167 8.4111 94.6508 61.5826
C57BR/cdJ m 69.55 7.2843 83.8689 55.2311
C57L/J f 65.7875 7.2843 80.1064 51.4686
C57L/J m 69.475 7.2843 83.7939 55.1561
CBA/J f 49.55 7.2843 63.8689 35.2311
CBA/J m 62.175 7.2843 76.4939 47.8561
CE/J f 76.8625 7.2843 91.1814 62.5436
CE/J m 70.0889 6.8677 83.5889 56.5889
DBA/1J f 46.47 6.5152 59.2772 33.6628
DBA/1J m 47.3 7.2843 61.6189 32.9811
DBA/2J f 58.825 7.2843 73.1439 44.5061
DBA/2J m 68.77 6.5152 81.5772 55.9628
FVB/NJ f 49.1125 7.2843 63.4314 34.7936
FVB/NJ m 71.3857 7.7872 86.6933 56.0781
I/LnJ f 51.8429 7.7872 67.1504 36.5353
I/LnJ m 59.12 9.2139 77.2322 41.0078
KK/HlJ f 74.9625 7.2843 89.2814 60.6436
KK/HlJ m 63.5333 8.4111 80.0674 46.9992
LP/J f 34.975 7.2843 49.2939 20.6561
LP/J m 54.05 7.2843 68.3689 39.7311
NOD/ShiLtJ f 43.325 7.2843 57.6439 29.0061
NOD/ShiLtJ m 41.8625 7.2843 56.1814 27.5436
NON/ShiLtJ f 54.425 7.2843 68.7439 40.1061
NON/ShiLtJ m 82.375 7.2843 96.6939 68.0561
NZW/LacJ f 46.25 7.2843 60.5689 31.9311
NZW/LacJ m 42.6625 7.2843 56.9814 28.3436
PL/J f 53.6375 7.2843 67.9564 39.3186
PL/J m 57.075 7.2843 71.3939 42.7561
RIIIS/J f 61.4625 7.2843 75.7814 47.1436
RIIIS/J m 57.45 7.2843 71.7689 43.1311
SJL/J f 45.6875 7.2843 60.0064 31.3686
SJL/J m 39.65 7.2843 53.9689 25.3311
SM/J f 58.2625 7.2843 72.5814 43.9436
SM/J m 73.3375 7.2843 87.6564 59.0186
SWR/J f 39.05 7.2843 53.3689 24.7311
SWR/J m 44.0556 6.8677 57.5556 30.5555


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 48.4812 5.1507 58.6063 38.3562
A/J both 65.05 5.1507 75.175 54.925
AKR/J both 55.9625 5.1507 66.0875 45.8375
BALB/cByJ both 79.6937 5.1507 89.8188 69.5687
BALB/cJ both 96.825 4.607 105.8811 87.7689
BTBR T+ Itpr3tf/J both 93.775 5.1507 103.9 83.65
BUB/BnJ both 72.0259 5.3315 82.5063 61.5455
C3H/HeJ both 53.5312 5.1507 63.6563 43.4062
C57BL/10J both 80.1848 5.3315 90.6652 69.7044
C57BL/6J both 78.5637 4.8294 88.0571 69.0704
C57BLKS/J both 63.7955 4.7867 73.2048 54.3861
C57BR/cdJ both 73.8333 5.5634 84.7696 62.8971
C57L/J both 67.6312 5.1507 77.7563 57.5062
CBA/J both 55.8625 5.1507 65.9875 45.7375
CE/J both 73.4757 5.0056 83.3154 63.6359
DBA/1J both 46.885 4.8864 56.4904 37.2796
DBA/2J both 63.7975 4.8864 73.4029 54.1921
FVB/NJ both 60.2491 5.3315 70.7295 49.7687
I/LnJ both 55.4814 6.0319 67.3386 43.6242
KK/HlJ both 69.2479 5.5634 80.1842 58.3116
LP/J both 44.5125 5.1507 54.6375 34.3875
NOD/ShiLtJ both 42.5937 5.1507 52.7188 32.4687
NON/ShiLtJ both 68.4 5.1507 78.525 58.275
NZW/LacJ both 44.4562 5.1507 54.5813 34.3312
PL/J both 55.3563 5.1507 65.4813 45.2312
RIIIS/J both 59.4562 5.1507 69.5813 49.3312
SJL/J both 42.6687 5.1507 52.7938 32.5437
SM/J both 65.8 5.1507 75.925 55.675
SWR/J both 41.5528 5.0056 51.3925 31.713




  GWAS USING LINEAR MIXED MODELS