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Project measure / variable:   Cheverud1   leptin_hifat

ID, description, units MPD:17891   leptin_hifat   leptin (serum)   [pg/mL]  high-fat diet  
high-fat diet study
Data set, strains Cheverud1   LGXSM w/par   10 strains     sex: both     age: 20-30wks
Procedure hormone quantification
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  STRAIN COMPARISON PLOT
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Cheverud1 - leptin (serum) high-fat diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains10 strains
Mean of the strain means30.4   pg/mL 26.5   pg/mL
Median of the strain means29.1   pg/mL 27.9   pg/mL
SD of the strain means± 13.7 ± 8.66
Coefficient of variation (CV)0.450 0.326
Min–max range of strain means11.0   –   58.4   pg/mL 8.43   –   39.3   pg/mL
Mean sample size per strain5.6   mice 6.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1390.6998 1390.6998 12.3916 0.0007
strain 8 12731.9466 1591.4933 14.1808 < 0.0001
sex:strain 8 2233.9743 279.2468 2.4882 0.017
Residuals 94 10549.5117 112.2288


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
LGXSM10 f 38.8 9.09   5 4.06 0.234 30.8, 52.7 0.62
LGXSM10 m 23.5 14.0   9 4.66 0.595 4.5, 44.8 -0.35
LGXSM15 f 29.1 17.2   7 6.49 0.59 4.12, 47.2 -0.09
LGXSM15 m 18.7 14.9   10 4.72 0.797 1.0, 39.9 -0.9
LGXSM18 f 26.1 5.65   5 2.53 0.216 20.0, 33.4 -0.31
LGXSM18 m 33.3 7.16   6 2.92 0.215 21.2, 40.3 0.78
LGXSM19 f 38.0 9.91   6 4.05 0.261 21.9, 49.0 0.56
LGXSM19 m 31.4 3.93   7 1.48 0.125 26.7, 38.4 0.56
LGXSM22 f 58.4 12.1   10 3.83 0.208 41.3, 83.2 2.05
LGXSM22 m 39.3 8.65   9 2.88 0.22 26.5, 58.8 1.48
LGXSM23 m 29.2 9.71   7 3.67 0.333 11.6, 40.5 0.31
LGXSM33 f 29.6 6.34   7 2.4 0.214 18.1, 38.0 -0.06
LGXSM33 m 31.6 6.15   6 2.51 0.194 24.7, 40.2 0.59
LGXSM38 f 11.0 5.6   5 2.5 0.507 5.0, 18.3 -1.42
LGXSM38 m 8.43 10.8   5 4.82 1.28 1.0, 27.5 -2.09
LGXSM45 f 18.3 2.68   3 1.55 0.147 15.3, 20.5 -0.88
LGXSM45 m 26.6 12.4   3 7.16 0.466 12.4, 35.4 0.01
LGXSM5 f 24.2 9.78   4 4.89 0.404 15.2, 38.1 -0.45
LGXSM5 m 23.2 9.56   5 4.27 0.412 8.76, 30.6 -0.38


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
LGXSM10 f 38.76 4.7377 48.1668 29.3532
LGXSM10 m 23.5089 3.5313 30.5203 16.4975
LGXSM15 f 29.0914 4.0041 37.0416 21.1412
LGXSM15 m 18.728 3.3501 25.3796 12.0764
LGXSM18 f 26.14 4.7377 35.5468 16.7332
LGXSM18 m 33.2667 4.3249 41.8539 24.6795
LGXSM19 f 37.9667 4.3249 46.5539 29.3795
LGXSM19 m 31.4286 4.0041 39.3788 23.4784
LGXSM22 f 58.38 3.3501 65.0316 51.7284
LGXSM22 m 39.2778 3.5313 46.2892 32.2664
LGXSM33 f 29.6143 4.0041 37.5645 21.6641
LGXSM33 m 31.6333 4.3249 40.2205 23.0461
LGXSM38 f 11.032 4.7377 20.4388 1.6252
LGXSM38 m 8.432 4.7377 17.8388 0.0
LGXSM45 f 18.2667 6.1163 30.4108 6.1225
LGXSM45 m 26.5667 6.1163 38.7108 14.4225
LGXSM5 f 24.2 5.2969 34.7171 13.6829
LGXSM5 m 23.212 4.7377 32.6188 13.8052


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
LGXSM10 both 31.1344 2.9545 37.0006 25.2683
LGXSM15 both 23.9097 2.6103 29.0926 18.7268
LGXSM18 both 29.7033 3.2074 36.0718 23.3349
LGXSM19 both 34.6976 2.9469 40.5488 28.8464
LGXSM22 both 48.8289 2.4338 53.6612 43.9966
LGXSM33 both 30.6238 2.9469 36.475 24.7726
LGXSM38 both 9.732 3.3501 16.3836 3.0804
LGXSM45 both 22.4167 4.3249 31.0039 13.8295
LGXSM5 both 23.706 3.5533 30.7611 16.6509




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA