Project measure / variable:   Schoonjans1   TCA_liver_HFD

ID, description, units MPD:112840   TCA_liver_HFD   bile acid taurocholic acid amount in liver, at 29 wks   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 29wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid taurocholic acid amount in liver, at 29 wks HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means25.7   ng/mL
Median of the strain means20.815   ng/mL
SD of the strain means± 14.071
Coefficient of variation (CV)0.5475
Min–max range of strain means8.0604   –   77.95   ng/mL
Mean sample size per strain4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 33563.2138 958.949 6.609 < 0.0001
Residuals 141 20458.8347 145.0981


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 62.33 25.155   5 11.25 0.4036 43.294, 94.62 2.6
BXD100 m 21.362 7.8668   7 2.9734 0.3683 10.396, 32.998 -0.31
BXD11 m 8.0604 2.8433   3 1.6416 0.3528 5.5204, 11.132 -1.25
BXD12 m 18.459 8.6969   4 4.3484 0.4712 8.8592, 29.828 -0.51
BXD27 m 30.423 12.044   5 5.3861 0.3959 18.562, 49.187 0.34
BXD32 m 25.871 7.4239   4 3.7119 0.287 16.601, 33.528 0.01
BXD34 m 47.898 26.978   4 13.489 0.5632 31.0, 87.67 1.58
BXD39 m 25.066 5.6066   5 2.5074 0.2237 19.503, 33.616 -0.05
BXD40 m 15.946 4.5015   5 2.0131 0.2823 11.561, 22.021 -0.69
BXD43 m 21.919 12.355   5 5.5253 0.5637 11.613, 43.275 -0.27
BXD45 m 20.447 5.8946   5 2.6361 0.2883 12.427, 28.414 -0.37
BXD48 m 24.2 7.2151   5 3.2267 0.2981 12.786, 32.841 -0.11
BXD48a m 36.214 17.013   5 7.6085 0.4698 20.799, 61.8 0.75
BXD49 m 24.681 10.823   5 4.8402 0.4385 12.894, 36.871 -0.07
BXD51 m 42.27 8.1298   5 3.6357 0.1923 33.472, 54.32 1.18
BXD53 m 27.09 6.5489   5 2.9287 0.2417 19.573, 37.176 0.1
BXD55 m 15.734 7.0002   5 3.1306 0.4449 8.3999, 24.343 -0.71
BXD6 m 13.545 1.5268   5 0.68279 0.1127 11.042, 14.825 -0.86
BXD62 m 16.269 5.5398   5 2.4775 0.3405 11.344, 24.032 -0.67
BXD63 m 20.829 4.7462   5 2.1226 0.2279 15.666, 26.663 -0.35
BXD64 m 24.476 10.695   5 4.7831 0.437 15.46, 41.639 -0.09
BXD66 m 16.433 7.6067   9 2.5356 0.4629 7.4211, 31.441 -0.66
BXD67 m 18.071 3.9098   5 1.7485 0.2164 14.469, 24.334 -0.54
BXD69 m 26.043 20.071   5 8.9762 0.7707 8.9296, 60.87 0.02
BXD73 m 13.278 1.7898   5 0.80041 0.1348 11.411, 14.971 -0.88
BXD75 m 39.07 15.11   4 7.5549 0.3867 26.888, 58.68 0.95
BXD77 m 18.081 5.732   5 2.5635 0.317 10.623, 24.74 -0.54
BXD79 m 17.388 10.456   5 4.6759 0.6013 7.6423, 32.98 -0.59
BXD8 m 18.406 7.9284   4 3.9642 0.4308 9.4165, 27.632 -0.52
BXD81 m 18.555 4.301   5 1.9234 0.2318 12.49, 24.313 -0.51
BXD84 m 20.801 11.272   5 5.041 0.5419 13.061, 39.972 -0.35
BXD87 m 40.253 21.115   5 9.4428 0.5246 14.345, 67.63 1.03
BXD89 m 18.168 5.5653   5 2.4889 0.3063 13.242, 26.883 -0.54
BXD90 m 20.198 6.7622   3 3.9042 0.3348 15.946, 27.996 -0.39
C57BL/6J m 77.95 31.608   5 14.136 0.4055 34.236, 120.2 3.71
DBA/2J m 19.405 5.3418   5 2.3889 0.2753 13.532, 26.664 -0.45


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 62.3308 5.3869865124 72.9805032653 51.6810967347
BXD100 m 21.362 4.5528345711 30.3626420262 12.3613579738
BXD11 m 8.0604 6.954569683 21.8091077961 -5.6883077961
BXD12 m 18.45855 6.0228340178 30.3652802207 6.5518197793
BXD27 m 30.4234 5.3869865124 41.0731032653 19.7736967347
BXD32 m 25.8715 6.0228340178 37.7782302207 13.9647697793
BXD34 m 47.89775 6.0228340178 59.8044802207 35.9910197793
BXD39 m 25.0664 5.3869865124 35.7161032653 14.4166967347
BXD40 m 15.9464 5.3869865124 26.5961032653 5.2966967347
BXD43 m 21.9192 5.3869865124 32.5689032653 11.2694967347
BXD45 m 20.4472 5.3869865124 31.0969032653 9.7974967347
BXD48 m 24.2004 5.3869865124 34.8501032653 13.5506967347
BXD48a m 36.2136 5.3869865124 46.8633032653 25.5638967347
BXD49 m 24.681 5.3869865124 35.3307032653 14.0312967347
BXD51 m 42.2698 5.3869865124 52.9195032653 31.6200967347
BXD53 m 27.0898 5.3869865124 37.7395032653 16.4400967347
BXD55 m 15.73378 5.3869865124 26.3834832653 5.0840767347
BXD6 m 13.5446 5.3869865124 24.1943032653 2.8948967347
BXD62 m 16.2686 5.3869865124 26.9183032653 5.6188967347
BXD63 m 20.8292 5.3869865124 31.4789032653 10.1794967347
BXD64 m 24.4762 5.3869865124 35.1259032653 13.8264967347
BXD66 m 16.4333444444 4.0152226786 24.3711645916 8.4955242973
BXD67 m 18.0708 5.3869865124 28.7205032653 7.4210967347
BXD69 m 26.04272 5.3869865124 36.6924232653 15.3930167347
BXD73 m 13.2782 5.3869865124 23.9279032653 2.6284967347
BXD75 m 39.07025 6.0228340178 50.9769802207 27.1635197793
BXD77 m 18.0808 5.3869865124 28.7305032653 7.4310967347
BXD79 m 17.38832 5.3869865124 28.0380232653 6.7386167347
BXD8 m 18.405625 6.0228340178 30.3123552207 6.4988947793
BXD81 m 18.5554 5.3869865124 29.2051032653 7.9056967347
BXD84 m 20.8014 5.3869865124 31.4511032653 10.1516967347
BXD87 m 40.2532 5.3869865124 50.9029032653 29.6034967347
BXD89 m 18.1684 5.3869865124 28.8181032653 7.5186967347
BXD90 m 20.1983333333 6.954569683 33.9470411295 6.4496255372
C57BL/6J m 77.9452 5.3869865124 88.5949032653 67.2954967347
DBA/2J m 19.4054 5.3869865124 30.0551032653 8.7556967347




  GWAS USING LINEAR MIXED MODELS