Project measure / variable:   Schoonjans1   aMCA_feces_HFD

ID, description, units MPD:112761   aMCA_feces_HFD   bile acid α-muricholic acid amount in feces, at 24 wks   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 24wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid α-muricholic acid amount in feces, at 24 wks HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means16.831   ng/mL
Median of the strain means14.41   ng/mL
SD of the strain means± 11.058
Coefficient of variation (CV)0.657
Min–max range of strain means2.8889   –   49.16   ng/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 21037.3417 601.0669 6.6829 < 0.0001
Residuals 136 12232.0623 89.9416


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 19.923 4.972   5 2.2236 0.2496 12.846, 25.555 0.28
BXD100 m 5.5938 2.9168   4 1.4584 0.5214 2.1163, 8.4065 -1.02
BXD11 m 6.4498 4.1011   3 2.3678 0.6359 3.5997, 11.15 -0.94
BXD12 m 6.5943 3.6815   4 1.8407 0.5583 1.526, 10.114 -0.93
BXD27 m 34.758 31.399   6 12.819 0.9034 8.0433, 94.4 1.62
BXD32 m 20.615 7.1313   4 3.5657 0.3459 11.922, 29.382 0.34
BXD34 m 19.041 5.6539   4 2.827 0.2969 13.917, 24.696 0.2
BXD39 m 6.6857 2.2905   5 1.0244 0.3426 4.1665, 9.4834 -0.92
BXD40 m 7.48 4.0683   5 1.8194 0.5439 3.1181, 13.615 -0.85
BXD43 m 9.4922 2.3668   5 1.0585 0.2493 7.1453, 12.483 -0.66
BXD45 m 13.028 6.8316   5 3.0552 0.5244 5.1513, 23.374 -0.34
BXD48 m 49.16 14.157   5 6.3313 0.288 32.353, 63.19 2.92
BXD48a m 20.451 6.0883   5 2.7228 0.2977 13.908, 26.764 0.33
BXD49 m 7.5379 4.7879   5 2.1412 0.6352 3.5568, 15.377 -0.84
BXD51 m 30.033 7.0123   5 3.136 0.2335 23.023, 41.242 1.19
BXD53 m 7.1792 4.0767   5 1.8231 0.5678 0.81464, 11.555 -0.87
BXD55 m 19.006 3.6279   5 1.6225 0.1909 13.067, 22.11 0.2
BXD6 m 2.8889 1.5191   5 0.67937 0.5258 1.3249, 5.2648 -1.26
BXD62 m 14.848 8.4323   5 3.7711 0.5679 4.9088, 26.895 -0.18
BXD63 m 14.622 4.9999   5 2.236 0.3419 9.6703, 20.053 -0.2
BXD64 m 8.7423 3.0154   5 1.3485 0.3449 3.777, 11.594 -0.73
BXD66 m 13.828 7.0982   5 3.1744 0.5133 9.3079, 26.308 -0.27
BXD67 m 10.632 4.6597   5 2.0839 0.4383 4.4024, 14.913 -0.56
BXD69 m 18.209 5.286   5 2.364 0.2903 11.956, 25.801 0.12
BXD73 m 11.057 4.399   5 1.9673 0.3978 5.0404, 15.42 -0.52
BXD75 m 36.104 19.417   5 8.6833 0.5378 11.387, 54.17 1.74
BXD77 m 39.897 15.819   5 7.0743 0.3965 21.457, 54.67 2.09
BXD79 m 8.4147 4.0   5 1.7889 0.4754 2.5043, 13.35 -0.76
BXD8 m 4.862 2.3513   4 1.1756 0.4836 1.9661, 7.4571 -1.08
BXD81 m 19.213 5.336   5 2.3863 0.2777 15.638, 28.527 0.22
BXD84 m 12.33 7.1829   3 4.1471 0.5825 7.9731, 20.621 -0.41
BXD87 m 14.199 8.9134   5 3.9862 0.6277 6.0713, 27.968 -0.24
BXD89 m 15.052 2.0288   5 0.90732 0.1348 13.527, 18.085 -0.16
BXD90 m 36.223 13.394   5 5.9898 0.3698 26.932, 59.59 1.75
C57BL/6J m 21.753 6.9644   5 3.1146 0.3202 14.071, 30.362 0.45
DBA/2J m 20.002 7.7724   5 3.4759 0.3886 8.4338, 29.935 0.29


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 19.9228 4.2412647722 28.3101588565 11.5354411435
BXD100 m 5.593825 4.7418781706 14.9711772774 -3.7835272774
BXD11 m 6.4497666667 5.4754492765 17.2778003899 -4.3782670566
BXD12 m 6.59425 4.7418781706 15.9716022774 -2.7831022774
BXD27 m 34.7578833333 3.8717273135 42.414459406 27.1013072607
BXD32 m 20.615 4.7418781706 29.9923522774 11.2376477226
BXD34 m 19.0405 4.7418781706 28.4178522774 9.6631477226
BXD39 m 6.6857 4.2412647722 15.0730588565 -1.7016588565
BXD40 m 7.48 4.2412647722 15.8673588565 -0.9073588565
BXD43 m 9.4922 4.2412647722 17.8795588565 1.1048411435
BXD45 m 13.02824 4.2412647722 21.4155988565 4.6408811435
BXD48 m 49.1596 4.2412647722 57.5469588565 40.7722411435
BXD48a m 20.4512 4.2412647722 28.8385588565 12.0638411435
BXD49 m 7.5379 4.2412647722 15.9252588565 -0.8494588565
BXD51 m 30.0332 4.2412647722 38.4205588565 21.6458411435
BXD53 m 7.179228 4.2412647722 15.5665868565 -1.2081308565
BXD55 m 19.006 4.2412647722 27.3933588565 10.6186411435
BXD6 m 2.8889 4.2412647722 11.2762588565 -5.4984588565
BXD62 m 14.84836 4.2412647722 23.2357188565 6.4610011435
BXD63 m 14.62226 4.2412647722 23.0096188565 6.2349011435
BXD64 m 8.74228 4.2412647722 17.1296388565 0.3549211435
BXD66 m 13.82762 4.2412647722 22.2149788565 5.4402611435
BXD67 m 10.63196 4.2412647722 19.0193188565 2.2446011435
BXD69 m 18.2092 4.2412647722 26.5965588565 9.8218411435
BXD73 m 11.05702 4.2412647722 19.4443788565 2.6696611435
BXD75 m 36.1036 4.2412647722 44.4909588565 27.7162411435
BXD77 m 39.8968 4.2412647722 48.2841588565 31.5094411435
BXD79 m 8.41472 4.2412647722 16.8020788565 0.0273611435
BXD8 m 4.862025 4.7418781706 14.2393772774 -4.5153272774
BXD81 m 19.2126 4.2412647722 27.5999588565 10.8252411435
BXD84 m 12.3304666667 5.4754492765 23.1585003899 1.5024329434
BXD87 m 14.19948 4.2412647722 22.5868388565 5.8121211435
BXD89 m 15.0518 4.2412647722 23.4391588565 6.6644411435
BXD90 m 36.2232 4.2412647722 44.6105588565 27.8358411435
C57BL/6J m 21.7532 4.2412647722 30.1405588565 13.3658411435
DBA/2J m 20.00176 4.2412647722 28.3891188565 11.6144011435




  GWAS USING LINEAR MIXED MODELS