Project measure / variable:   Schoonjans1   TbMCA_plasma_t60_HFD

ID, description, units MPD:112739   TbMCA_plasma_t60_HFD   plasma bile acid tauro-β-muricholic acid amount, glucose kinetic test, at 20 wks of age, after 60 min   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid tauro-β-muricholic acid amount, glucose kinetic test, at 20 wks of age, after 60 min HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means296.6   ng/mL
Median of the strain means265.4   ng/mL
SD of the strain means± 158.1
Coefficient of variation (CV)0.5328
Min–max range of strain means37.129   –   713.7   ng/mL
Mean sample size per strain4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 3850060.7384 110001.7354 1.7987 0.0103
Residuals 121 7400100.7389 61157.8573


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 118.4 46.25   5 20.684 0.3907 73.3, 181.7 -1.13
BXD100 m 185.9 130.1   9 43.354 0.6996 22.504, 389.4 -0.7
BXD11 m 269.4 31.579   3 18.232 0.1172 233.2, 291.1 -0.17
BXD12 m 713.7 1002.0   4 501.1 1.4043 91.02, 2211.0 2.64
BXD27 m 394.0 202.3   5 90.48 0.5135 263.9, 748.5 0.62
BXD32 m 183.5 104.5   4 52.25 0.5694 75.79, 313.7 -0.72
BXD34 m 382.7 272.2   4 136.1 0.7113 154.5, 776.0 0.54
BXD39 m 183.9 126.8   3 73.19 0.6892 60.4, 313.7 -0.71
BXD40 m 443.5 30.667   4 15.333 0.0691 399.1, 467.2 0.93
BXD43 m 378.2 159.7   5 71.43 0.4223 244.0, 654.9 0.52
BXD45 m 362.5 179.0   5 80.06 0.4939 209.7, 595.9 0.42
BXD48 m 261.4 178.3   5 79.74 0.682 96.01, 463.2 -0.22
BXD48a m 374.0 265.7   4 132.9 0.7106 144.6, 730.2 0.49
BXD49 m 592.5 215.4   5 96.32 0.3635 382.3, 879.0 1.87
BXD51 m 367.7 161.3   3 93.15 0.4388 270.3, 553.9 0.45
BXD53 m 212.6 175.0   5 78.26 0.8232 70.37, 485.3 -0.53
BXD55 m 189.6 30.708   5 13.733 0.162 143.7, 218.1 -0.68
BXD6 m 491.5 353.6   5 158.2 0.7195 115.0, 967.7 1.23
BXD62 m 383.2 78.15   4 39.074 0.2039 314.3, 462.7 0.55
BXD63 m 102.9 33.152   5 14.826 0.3222 71.31, 152.7 -1.23
BXD64 m 143.6 173.7   5 77.67 1.2092 46.784, 453.1 -0.97
BXD66 m 135.7 71.77   3 41.438 0.5287 85.84, 218.0 -1.02
BXD67 m 37.129 12.816   5 5.7313 0.3452 23.11, 56.62 -1.64
BXD69 m 423.2 168.0   4 83.98 0.3968 283.5, 641.7 0.8
BXD73 m 365.5 214.4   3 123.8 0.5865 146.6, 575.1 0.44
BXD75 m 425.0 408.0   4 204.0 0.9599 116.6, 984.2 0.81
BXD77 m 193.8 147.0   5 65.75 0.7589 70.65, 410.1 -0.65
BXD79 m 543.2 476.0   5 212.9 0.8764 130.1, 1246.0 1.56
BXD8 m 439.8 256.5   3 148.1 0.5833 198.4, 709.1 0.91
BXD81 m 227.1 192.5   5 86.07 0.8476 31.768, 494.3 -0.44
BXD84 m 167.0 184.9   5 82.68 1.107 46.37, 490.5 -0.82
BXD87 m 226.4 85.11   4 42.555 0.376 125.2, 322.7 -0.44
BXD89 m 146.7 30.518   5 13.648 0.208 119.8, 191.4 -0.95
BXD90 m 154.5 49.856   4 24.928 0.3226 110.1, 226.0 -0.9
C57BL/6J m 396.2 265.4   2   187.6 0.6697 208.6, 583.9 0.63
DBA/2J m 63.24 73.75   3 42.578 1.1662 13.786, 148.0 -1.48


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 118.382 110.5964351564 337.3368145849 -100.5728145849
BXD100 m 185.8982222222 82.4337156929 349.0975053598 22.6989390847
BXD11 m 269.4333333333 142.7793838369 552.1027834864 -13.2361168197
BXD12 m 713.705 123.6505735394 958.5039247063 468.9060752937
BXD27 m 393.96 110.5964351564 612.9148145849 175.0051854151
BXD32 m 183.5225 123.6505735394 428.3214247063 -61.2764247063
BXD34 m 382.7 123.6505735394 627.4989247063 137.9010752937
BXD39 m 183.9333333333 142.7793838369 466.6027834864 -98.7361168197
BXD40 m 443.525 123.6505735394 688.3239247063 198.7260752937
BXD43 m 378.2 110.5964351564 597.1548145849 159.2451854151
BXD45 m 362.46 110.5964351564 581.4148145849 143.5051854151
BXD48 m 261.422 110.5964351564 480.3768145849 42.4671854151
BXD48a m 373.95 123.6505735394 618.7489247063 129.1510752937
BXD49 m 592.48 110.5964351564 811.4348145849 373.5251854151
BXD51 m 367.6666666667 142.7793838369 650.3361168197 84.9972165136
BXD53 m 212.574 110.5964351564 431.5288145849 -6.3808145849
BXD55 m 189.56 110.5964351564 408.5148145849 -29.3948145849
BXD6 m 491.48 110.5964351564 710.4348145849 272.5251854151
BXD62 m 383.25 123.6505735394 628.0489247063 138.4510752937
BXD63 m 102.894 110.5964351564 321.8488145849 -116.0608145849
BXD64 m 143.6148 110.5964351564 362.5696145849 -75.3400145849
BXD66 m 135.7466666667 142.7793838369 418.4161168197 -146.9227834864
BXD67 m 37.1292 110.5964351564 256.0840145849 -181.8256145849
BXD69 m 423.25 123.6505735394 668.0489247063 178.4510752937
BXD73 m 365.5333333333 142.7793838369 648.2027834864 82.8638831803
BXD75 m 425.025 123.6505735394 669.8239247063 180.2260752937
BXD77 m 193.75 110.5964351564 412.7048145849 -25.2048145849
BXD79 m 543.16 110.5964351564 762.1148145849 324.2051854151
BXD8 m 439.7666666667 142.7793838369 722.4361168197 157.0972165136
BXD81 m 227.0736 110.5964351564 446.0284145849 8.1187854151
BXD84 m 167.0132 110.5964351564 385.9680145849 -51.9416145849
BXD87 m 226.375 123.6505735394 471.1739247063 -18.4239247063
BXD89 m 146.7 110.5964351564 365.6548145849 -72.2548145849
BXD90 m 154.525 123.6505735394 399.3239247063 -90.2739247063
C57BL/6J m 396.25 174.8683180946 742.447959374 50.052040626
DBA/2J m 63.2366666667 142.7793838369 345.9061168197 -219.4327834864




  GWAS USING LINEAR MIXED MODELS