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Project measure / variable:   Schoonjans1   wMCA_plasma_t30_CD

ID, description, units MPD:112716   wMCA_plasma_t30_CD   plasma bile acid ω-muricholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid ω-muricholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means78.73   ng/mL
Median of the strain means65.11   ng/mL
SD of the strain means± 50.71
Coefficient of variation (CV)0.6442
Min–max range of strain means16.151   –   225.4   ng/mL
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 401892.6312 11482.6466 2.3124 0.0004
Residuals 130 645551.1554 4965.7781


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 46.973 34.328   5 15.352 0.7308 21.934, 107.1 -0.63
BXD100 m 40.072 14.505   5 6.487 0.362 25.104, 57.8 -0.76
BXD11 m 51.33 21.688   4 10.844 0.4225 30.498, 74.24 -0.54
BXD12 m 80.41 78.18   3 45.139 0.9722 21.864, 169.2 0.03
BXD27 m 53.45 18.392   4 9.1959 0.3441 39.564, 78.72 -0.5
BXD32 m 138.7 185.8   5 83.11 1.3399 10.324, 463.5 1.18
BXD34 m 66.94 41.527   5 18.571 0.6203 30.754, 136.5 -0.23
BXD39 m 54.72 57.96   3 33.463 1.0593 19.228, 121.6 -0.47
BXD40 m 225.4 139.6   4 69.79 0.6192 117.7, 430.3 2.89
BXD43 m 27.08 14.055   7 5.3123 0.519 12.886, 54.22 -1.02
BXD45 m 104.0 57.7   4 28.852 0.555 36.998, 172.8 0.5
BXD48 m 89.65 31.514   5 14.094 0.3515 42.74, 119.4 0.22
BXD48a m 63.28 26.562   4 13.281 0.4198 38.164, 96.16 -0.3
BXD49 m 71.67 28.102   5 12.567 0.3921 23.776, 93.23 -0.14
BXD51 m 27.428 19.558   5 8.7465 0.7131 8.802, 58.5 -1.01
BXD53 m 116.2 51.71   4 25.853 0.4449 62.26, 178.4 0.74
BXD55 m 80.47 73.68   5 32.953 0.9157 15.196, 165.4 0.03
BXD6 m 212.3 159.2   5 71.19 0.7498 75.22, 444.9 2.63
BXD62 m 92.73 35.963   5 16.083 0.3878 48.472, 132.9 0.28
BXD63 m 29.758 11.607   4 5.8035 0.3901 21.476, 46.746 -0.97
BXD64 m 53.44 13.512   5 6.0425 0.2528 37.898, 73.71 -0.5
BXD66 m 58.51 22.851   5 10.219 0.3906 28.842, 82.8 -0.4
BXD67 m 67.77 27.554   4 13.777 0.4066 30.934, 96.88 -0.22
BXD69 m 26.857 8.4905   5 3.7971 0.3161 19.356, 39.04 -1.02
BXD73 m 122.1 176.7   4 88.33 1.4464 0.044, 384.4 0.86
BXD75 m 109.6 15.834   5 7.0811 0.1444 90.7, 129.6 0.61
BXD77 m 141.9 78.55   5 35.131 0.5536 59.17, 268.4 1.25
BXD79 m 91.41 66.71   5 29.836 0.7298 40.234, 201.1 0.25
BXD8 m 46.931 11.418   5 5.1064 0.2433 37.806, 65.72 -0.63
BXD81 m 179.5 217.1   3 125.4 1.2094 35.882, 429.3 1.99
BXD84 m 42.65 15.578   5 6.9668 0.3653 16.442, 55.1 -0.71
BXD87 m 82.91 57.59   5 25.754 0.6946 34.226, 180.3 0.08
BXD89 m 27.514 26.276   5 11.751 0.955 9.222, 71.83 -1.01
BXD90 m 16.151 5.7588   5 2.5754 0.3566 8.79, 23.166 -1.23
C57BL/6J m 58.16 21.77   5 9.736 0.3743 32.512, 86.57 -0.41
DBA/2J m 36.147 8.15   4 4.075 0.2255 29.358, 47.48 -0.84


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 46.9732 31.5143717004 109.320615462 -15.374215462
BXD100 m 40.0724 31.5143717004 102.419815462 -22.275015462
BXD11 m 51.3335 35.2341386951 121.0400295972 -18.3730295972
BXD12 m 80.4146666667 40.6848789206 160.9048339211 -0.0755005878
BXD27 m 53.4505 35.2341386951 123.1570295972 -16.2560295972
BXD32 m 138.6976 31.5143717004 201.045015462 76.350184538
BXD34 m 66.944 31.5143717004 129.291415462 4.596584538
BXD39 m 54.7153333333 40.6848789206 135.2055005878 -25.7748339211
BXD40 m 225.425 35.2341386951 295.1315295972 155.7184704028
BXD43 m 27.0798571429 26.6345053277 79.7730405919 -25.6133263062
BXD45 m 103.972 35.2341386951 173.6785295972 34.2654704028
BXD48 m 89.652 31.5143717004 151.999415462 27.304584538
BXD48a m 63.2785 35.2341386951 132.9850295972 -6.4280295972
BXD49 m 71.6732 31.5143717004 134.020615462 9.325784538
BXD51 m 27.4276 31.5143717004 89.775015462 -34.919815462
BXD53 m 116.2225 35.2341386951 185.9290295972 46.5159704028
BXD55 m 80.4668 31.5143717004 142.814215462 18.119384538
BXD6 m 212.304 31.5143717004 274.651415462 149.956584538
BXD62 m 92.7284 31.5143717004 155.075815462 30.380984538
BXD63 m 29.7575 35.2341386951 99.4640295972 -39.9490295972
BXD64 m 53.4376 31.5143717004 115.785015462 -8.909815462
BXD66 m 58.5072 31.5143717004 120.854615462 -3.840215462
BXD67 m 67.7685 35.2341386951 137.4750295972 -1.9380295972
BXD69 m 26.8572 31.5143717004 89.204615462 -35.490215462
BXD73 m 122.1325 35.2341386951 191.8390295972 52.4259704028
BXD75 m 109.618 31.5143717004 171.965415462 47.270584538
BXD77 m 141.894 31.5143717004 204.241415462 79.546584538
BXD79 m 91.4148 31.5143717004 153.762215462 29.067384538
BXD8 m 46.9312 31.5143717004 109.278615462 -15.416215462
BXD81 m 179.524 40.6848789206 260.0141672544 99.0338327456
BXD84 m 42.65 31.5143717004 104.997415462 -19.697415462
BXD87 m 82.9092 31.5143717004 145.256615462 20.561784538
BXD89 m 27.5144 31.5143717004 89.861815462 -34.833015462
BXD90 m 16.1508 31.5143717004 78.498215462 -46.196615462
C57BL/6J m 58.1556 31.5143717004 120.503015462 -4.191815462
DBA/2J m 36.147 35.2341386951 105.8535295972 -33.5595295972




  GWAS USING LINEAR MIXED MODELS