Project measure / variable:   Schoonjans1   TbMCA_plasma_t0_CD

ID, description, units MPD:112666   TbMCA_plasma_t0_CD   plasma bile acid tauro-β-muricholic acid, glucose kinetic test, at 20 wks of age, at 0 min   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid tauro-β-muricholic acid, glucose kinetic test, at 20 wks of age, at 0 min CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means81.13   ng/mL
Median of the strain means64.27   ng/mL
SD of the strain means± 53.87
Coefficient of variation (CV)0.664
Min–max range of strain means22.463   –   250.8   ng/mL
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 460599.2795 13159.9794 2.6281 < 0.0001
Residuals 131 655966.7558 5007.3798


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 22.744 10.96   5 4.9016 0.4819 8.412, 38.941 -1.08
BXD100 m 70.66 15.974   5 7.144 0.2261 56.56, 90.36 -0.19
BXD11 m 68.57 55.08   4 27.538 0.8032 13.612, 125.7 -0.23
BXD12 m 41.992 14.21   3 8.2041 0.3384 31.832, 58.23 -0.73
BXD27 m 250.8 236.5   4 118.3 0.9432 83.89, 598.3 3.15
BXD32 m 67.97 34.506   5 15.432 0.5076 27.078, 110.0 -0.24
BXD34 m 66.0 34.76   5 15.545 0.5266 10.502, 93.01 -0.28
BXD39 m 140.2 56.94   3 32.871 0.406 83.33, 197.2 1.1
BXD40 m 50.19 29.485   4 14.743 0.5875 27.002, 92.24 -0.57
BXD43 m 45.574 20.09   7 7.5935 0.4408 14.134, 70.03 -0.66
BXD45 m 90.24 67.94   4 33.971 0.7529 25.394, 166.3 0.17
BXD48 m 28.736 18.714   5 8.3693 0.6513 14.46, 59.62 -0.97
BXD48a m 40.679 23.5   4 11.75 0.5777 14.142, 71.4 -0.75
BXD49 m 46.284 10.139   5 4.5345 0.2191 29.426, 55.67 -0.65
BXD51 m 135.3 51.85   5 23.187 0.3833 59.57, 185.4 1.01
BXD53 m 78.38 48.931   4 24.465 0.6243 48.89, 151.5 -0.05
BXD55 m 22.463 2.994   5 1.339 0.1333 19.46, 25.87 -1.09
BXD6 m 168.8 125.4   5 56.07 0.7426 39.54, 329.5 1.63
BXD62 m 139.9 60.75   5 27.168 0.4342 79.62, 207.9 1.09
BXD63 m 27.73 7.333   4 3.6665 0.2644 19.906, 37.62 -0.99
BXD64 m 164.1 49.654   5 22.206 0.3026 98.67, 224.7 1.54
BXD66 m 101.6 51.7   5 23.12 0.5086 57.51, 179.4 0.38
BXD67 m 84.25 51.19   4 25.594 0.6075 14.214, 125.7 0.06
BXD69 m 62.54 33.009   5 14.762 0.5278 30.33, 105.2 -0.35
BXD73 m 52.41 45.426   4 22.713 0.8667 11.316, 116.4 -0.53
BXD75 m 210.3 240.1   5 107.4 1.1421 44.562, 629.7 2.4
BXD77 m 53.95 26.12   5 11.681 0.4841 32.746, 95.45 -0.5
BXD79 m 104.4 49.1   5 21.958 0.4701 63.7, 181.8 0.43
BXD8 m 117.3 102.6   5 45.887 0.8745 20.928, 273.8 0.67
BXD81 m 31.157 21.873   3 12.628 0.702 7.6972, 50.99 -0.93
BXD84 m 86.33 32.881   5 14.705 0.3809 30.94, 111.1 0.1
BXD87 m 57.22 15.643   5 6.996 0.2734 34.482, 73.13 -0.44
BXD89 m 47.688 32.877   6 13.422 0.6894 18.852, 105.3 -0.62
BXD90 m 40.638 19.111   5 8.5466 0.4703 14.012, 63.57 -0.75
C57BL/6J m 45.654 7.9794   5 3.5685 0.1748 35.252, 55.41 -0.66
DBA/2J m 57.98 42.552   4 21.276 0.7339 18.96, 114.1 -0.43


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 22.7438 31.6461050224 85.3473445719 -39.8597445719
BXD100 m 70.662 31.6461050224 133.2655445719 8.0584554281
BXD11 m 68.5745 35.3814210266 138.5673906476 -1.4183906476
BXD12 m 41.992 40.8549459081 122.8128285135 -38.8288285135
BXD27 m 250.7975 35.3814210266 320.7903906476 180.8046093524
BXD32 m 67.9748 31.6461050224 130.5783445719 5.3712554281
BXD34 m 66.0024 31.6461050224 128.6059445719 3.3988554281
BXD39 m 140.2433333333 40.8549459081 221.0641618468 59.4225048198
BXD40 m 50.186 35.3814210266 120.1788906476 -19.8068906476
BXD43 m 45.574 26.7458403053 98.483652056 -7.335652056
BXD45 m 90.242 35.3814210266 160.2348906476 20.2491093524
BXD48 m 28.7356 31.6461050224 91.3391445719 -33.8679445719
BXD48a m 40.679 35.3814210266 110.6718906476 -29.3138906476
BXD49 m 46.284 31.6461050224 108.8875445719 -16.3195445719
BXD51 m 135.274 31.6461050224 197.8775445719 72.6704554281
BXD53 m 78.375 35.3814210266 148.3678906476 8.3821093524
BXD55 m 22.4628 31.6461050224 85.0663445719 -40.1407445719
BXD6 m 168.828 31.6461050224 231.4315445719 106.2244554281
BXD62 m 139.914 31.6461050224 202.5175445719 77.3104554281
BXD63 m 27.7305 35.3814210266 97.7233906476 -42.2623906476
BXD64 m 164.114 31.6461050224 226.7175445719 101.5104554281
BXD66 m 101.646 31.6461050224 164.2495445719 39.0424554281
BXD67 m 84.2535 35.3814210266 154.2463906476 14.2606093524
BXD69 m 62.5432 31.6461050224 125.1467445719 -0.0603445719
BXD73 m 52.4105 35.3814210266 122.4033906476 -17.5823906476
BXD75 m 210.2524 31.6461050224 272.8559445719 147.6488554281
BXD77 m 53.9524 31.6461050224 116.5559445719 -8.6511445719
BXD79 m 104.436 31.6461050224 167.0395445719 41.8324554281
BXD8 m 117.3316 31.6461050224 179.9351445719 54.7280554281
BXD81 m 31.1570666667 40.8549459081 111.9778951802 -49.6637618468
BXD84 m 86.334 31.6461050224 148.9375445719 23.7304554281
BXD87 m 57.2184 31.6461050224 119.8219445719 -5.3851445719
BXD89 m 47.688 28.8888092966 104.836955903 -9.460955903
BXD90 m 40.6384 31.6461050224 103.2419445719 -21.9651445719
C57BL/6J m 45.654 31.6461050224 108.2575445719 -16.9495445719
DBA/2J m 57.9835 35.3814210266 127.9763906476 -12.0093906476




  GWAS USING LINEAR MIXED MODELS