MPD: Data set: Zaytseva1

Krištić J, Zaytseva OO, Ram R, Nguyen Q, Novokmet M, Vučković F, Vilaj M, Trbojević-Akmačić I, Pezer M, Davern KM, Morahan G, Lauc G. Profiling and genetic control of the murine immunoglobulin G glycome. Nat Chem Biol. 2018 May;14(5):516-524. doi: 10.1038/s41589-018-0034-3. Epub 2018 Apr 9. PubMed 29632412

Zaytseva1 downloads
• Download Zaytseva1 project data set animal data, as uploaded
• Download Zaytseva1 project data set animal data, as uploaded
• Download Zaytseva1 animal data matrix with factor-related expansion applied as necessary
• Download Zaytseva1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Zaytseva1 measures:

Investigators	Olga O Zaytseva Glycoscience Research Laboratory, Genos Ltd, Zagreb CROATIA Jasminka Krištić Glycoscience Research Laboratory, Genos Ltd, Zagreb CROATIA Grant Morahan Harry Perkins Institute of Medical Research, Nedlands, Western Australia AUSTRALIA Gordan Lauc University of Zagreb, Zagreb CROATIA
Participants	Ram R, Nguyen Q, Novokmet M, Vučković F, Vilaj M, Trbojević-Akmačić I, Pezer M, Davern KM
Contact	Gordan Lauc glauc@pharma.hr Lab web site
Acknowledgements	Funding provided by WA Diabetes Research Foundation, Program 1037321; National Health and Medical Research Council of Australia, Project 1069173; European Commission FP7 grants MIMOmics, contract 305280, H2020 projects GlySign contract 722095, IMforFuture contract 721815; European Structural and Investment Funds IRI grant KK.01.2.1.01.0003; Croatian National Centre of Research Excellence in Personalized Healthcare grant KK.01.1.1.01.0010.
Project type	Phenotype strain survey data set
MPD identifiers	Zaytseva1 MPD:651
Data changelog	No updates/corrections. Initial release date: 10/2019.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

The immunoglobulin IgG glycome was characterized in Collaborative Cross strains originating at Geniad. This project contains data for glycan levels in 111 CC strains and Zaytseva2 contains data for N-glycan profiles of IgG subclasses in 95 CC strains.

Procedures conducted:

• glycosylation profile

IgG glycan peaks, relative abundance

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Zaytseva1:1	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 1, core fucose with 1 GlcNAc antenna (relative abundance) [%] gp1 110006	CC	111	both	4-140wks	N=3

Zaytseva1:2	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 2, composition not determined (relative abundance) [%] gp2 110007	CC	111	both	4-140wks	N=3

Zaytseva1:3	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 3, composition not determined (relative abundance) [%] gp3 110008	CC	111	both	4-140wks	N=3

Zaytseva1:4	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 4, core fucose with 2 GlcNAc antennae (relative abundance) [%] gp4 110009	CC	111	both	4-140wks	N=3

Zaytseva1:5	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 5, composition not determined (relative abundance) [%] gp5 110010	CC	111	both	4-140wks	N=3

Zaytseva1:6	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 6, core fucose with bisecting GlcNAc and 2 GlcNAc antennae (relative abundance) [%] gp6 110011	CC	111	both	4-140wks	N=3

Zaytseva1:7	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 7, composition not determined (relative abundance) [%] gp7 110012	CC	111	both	4-140wks	N=3

Zaytseva1:8	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 8, core fucose with 2 GlcNAc antennae, 1 galactose linked to alpha1,6-linked core mannose (relative abundance) [%] gp8 110013	CC	111	both	4-140wks	N=3

Zaytseva1:9	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 9, core fucose with 2 GlcNAc antennae, 1 galactose linked to alpha1,3-linked core mannose (relative abundance) [%] gp9 110014	CC	111	both	4-140wks	N=3

Zaytseva1:10	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 10, core fucose with bisecting GlcNAc and 2 GlcNAc antennae, 1 galactose linked to alpha1,6-linked core mannose (relative abundance) [%] gp10 110015	CC	111	both	4-140wks	N=3

Zaytseva1:11	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 11, composition not determined (relative abundance) [%] gp11 110016	CC	111	both	4-140wks	N=3

Zaytseva1:12	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 12, composition not determined (relative abundance) [%] gp12 110017	CC	111	both	4-140wks	N=3

Zaytseva1:13	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 13, composition not determined (relative abundance) [%] gp13 110018	CC	111	both	4-140wks	N=3

Zaytseva1:14	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 14, core fucose with 2 GlcNAc antennae, 2 galactoses (relative abundance) [%] gp14 110019	CC	111	both	4-140wks	N=3

Zaytseva1:15	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 15, composition not determined (relative abundance) [%] gp15 110020	CC	111	both	4-140wks	N=3

Zaytseva1:16	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 16, composition not determined (relative abundance) [%] gp16 110021	CC	111	both	4-140wks	N=3

Zaytseva1:17	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 17a, core fucose with 2 GlcNAc antennae, 1 galactose linked to alpha1,6-linked core mannose, 1 sialic acid (relative abundance) [%] gp17a 110022	CC	111	both	4-140wks	N=3

Zaytseva1:18	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 17b, core fucose with 2 GlcNAc antennae, 1 galactose linked to alpha1,3-linked core mannose, 1 sialic acid (relative abundance) [%] gp17b 110023	CC	111	both	4-140wks	N=3

Zaytseva1:19	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 18, composition not determined (relative abundance) [%] gp18 110024	CC	111	both	4-140wks	N=3

Zaytseva1:20	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 19, composition not determined (relative abundance) [%] gp19 110025	CC	111	both	4-140wks	N=3

Zaytseva1:21	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 20, core fucose with 2 GlcNAc antennae, 2 galactoses, 1 sialic acid (relative abundance) [%] gp20 110026	CC	111	both	4-140wks	N=3

Zaytseva1:22	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 21, composition not determined (relative abundance) [%] gp21 110027	CC	111	both	4-140wks	N=3

Zaytseva1:23	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 22, composition not determined (relative abundance) [%] gp22 110028	CC	111	both	4-140wks	N=3

Zaytseva1:24	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 23, core fucose with 2 GlcNAc antennae, 3 galactoses, 1 sialic acid (relative abundance) [%] gp23 110029	CC	111	both	4-140wks	N=3

Zaytseva1:25	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 24, composition not determined (relative abundance) [%] gp24 110030	CC	111	both	4-140wks	N=3

Zaytseva1:26	Zaytseva1	glycosylation profile	(none)	IgG glycan peak 25, core fucose with 2 GlcNAc antennae, 2 galactoses, 2 sialic acids (relative abundance) [%] gp25 110031	CC	111	both	4-140wks	N=3

Zaytseva1: IgG glycome: Glycan levels in 111 Collaborative Cross strains of mice (2018)