MPD: Data set: Yuan5

Yuan5: QTL analysis of circulating adhesion molecules in apoE-/- mice (2008)

Yuan Z, Su Z, Miyoshi T, Rowlan JS, Shi W. Quantitative trait locus analysis of circulating adhesion molecules in hyperlipidemic apolipoprotein E-deficient mice. Mol Genet Genomics. 2008 Nov;280(5):375-83. Epub 2008 Aug 13. PubMed 18704499 FullText

Circulating soluble adhesion molecules are useful markers to predict several clinical conditions. To determine genetic factors influencing plasma levels of VCAM-1 and P-selectin, authors performed QTL analysis on an intercross between B6 and C3H strains deficient in apolipoprotein E. 234 female F2 mice were selected to do the experiments, and the analysis results indicate VCAM-1 and P-selectin levels are complex traits regulated by multiple genes, at least partially, by acting on body weight and lipid metabolism in hyperlipidemic apoE-/- mice.

Note on studied population: apoE-/-

Procedures conducted:

• study archive

Plasma levels of P-selectin and soluble vascular cell adhesion molecule-1.

Yuan5 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Yuan5 measures:

Investigators	Z Yuan Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Su Z, Miyoshi T, Rowlan JS, Shi W
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Grant: The current study was supported by the National Institutes of Health grant HL75433 and by the NHLBI Mammalian Genotyping Service (contract HV48141) for the genotyping.
Project type	QTL Archive data set
MPD identifiers	Yuan5 MPD:211
Data changelog	No updates/corrections. Initial release date: 03/2011.

QTL data set parameters:

Progenitor strains	B5.apoE^-/- C3H.apoE^-/-
Cross direction notation	(B6xC3H) F1 x (B6xC3H) F1
Cross type	F2 intercross
Population size	234 ♀ 0 ♂
Age	18wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Yuan5	biomarker quantification	(none)	plasma levels of P-selectin [ng/mL] P-selectin 21101	QTL population	f	18wks	N=234

Yuan5	biomarker quantification	(none)	plasma levels of soluble vascular cell adhesion molecule-1 [ng/mL] VCAM1 21102	QTL population	f	18wks	N=234

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Ppsl Pvacm1l

Project / data set: Yuan5 a.k.a. Yuan_2008
Excel file: Data_Description_B6xC3H_Yuan2008.xlsx
CSV file: Yuan2008_B6xC3H_B37_Data.csv
Readme / text file: readme_Yuan2008.txt