MPD: Data set: Vanderlinden1

Vanderlinden1: Drinking in the dark alcohol consumption in 43 ILSXISS recombinant inbred strains of mice (2015)

Vanderlinden LA, Saba LM, Bennett B, Hoffman PL, Tabakoff . Influence of sex on genetic regulation of 'drinking in the dark' alcohol consumption. Mamm Genome. 2015 Feb;26(1-2):43-56. doi: 10.1007/s00335-014-9553-8. Epub 2015 Jan 6. PubMed 25559016 FullText

Vanderlinden1 downloads
• Download Vanderlinden1 project data set animal data, as uploaded
• Download Vanderlinden1 animal data matrix with factor-related expansion applied as necessary
• Download Vanderlinden1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Vanderlinden1 measures:

Investigators	Lauren A Vanderlinden University of Colorado, Aurora, CO Laura Saba University of Colorado Denver School of Medicine, Aurora, CO Beth Bennett University of Colorado Denver School of Medicine, Aurora, CO Paula A Hoffman University of Colorado Denver School of Medicine, Aurora, CO Boris Tabakoff University of Colorado Denver School of Medicine, Aurora, CO
Contact	Lauren A Vanderlinden lauren.vanderlinden@ucdenver.edu
Acknowledgements	Funding provided by NIH AA013162, AA16649; Banbury Fund
Project type	Phenotype strain survey data set
MPD identifiers	Vanderlinden1 MPD:543
Data changelog	No updates/corrections. Initial release date: 04/2016.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

ILSXISS recombinant inbred mice were used to investigate genetic influences of alcohol consumption in the "drinking in the dark" model. Mice were given access to 20% ethanol during the early phase of their circadian dark cycle for four consecutive days. Alcohol-preferring strains of mice consume an amount of alcohol during this time that produces blood ethanol levels that are comparable to the levels that define binge drinking in humans.

Procedures conducted:

• body weight
• intake monitoring		Ethanol consumed during 2h availability during dark phase. 4 days/trials with variations.

Mice: ILSXISS 43 strains ♀♂ age 8-23wks 1 experimental group

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Vanderlinden1:1	Vanderlinden1	body weight	(none)	body weight at start of experiment on day 1 [g] bw 54301	ILSXISS	43	both	8-23wks	N=8

Vanderlinden1:11	Vanderlinden1	intake monitoring	(none)	ethanol consumed 'drinking in the dark' [g] EtOH 54311 day2 day3 day4	ILSXISS	43	both	8-23wks	N=8

Vanderlinden1:21	Vanderlinden1	intake monitoring	(none)	ethanol consumed 'drinking in the dark', log transformed [log(g)] EtOH_log 54321 day2 day3 day4	ILSXISS	43	both	8-23wks	N=8

Vanderlinden1:31	Vanderlinden1	intake monitoring	(none)	first principal component on log transformed 'drinking in the dark' measurements (days 2, 3, 4) PC1 54331	ILSXISS	43	both	8-23wks	N=8