MPD: Data set: Sugiyama3

Sugiyama3: Blood pressure and heart rate in males of F2 progeny of BALB/cJ and CBA/CaJ (2002)

Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B. QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice. Physiol Genomics. 2002 Jul 12;10(1):5-12. PubMed 12118100

Sugiyama3 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Sugiyama3 measures:

MA:0000010 cardiovascular system
MA:0000072 heart
MP:0001259 abnormal body weight
MP:0001629 abnormal heart rate
MP:0004857 abnormal heart weight
MP:0010695 abnormal blood pressure regulation
VT:0000183 blood pressure trait
VT:0001259 body mass
VT:0007028 heart mass
VT:2000009 heart pumping trait

Investigators	Fimihiro Sugiyama University of Tsukuba, Tsukuba JAPAN Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Funding provided by NIH HL66611, HL5500; American Heart Association Grant 50564N, American Health Assistance Foundation G1999023, Japanese Ministry of Education, Science, Sport, Culture, and Technology
Project type	QTL Archive data set
MPD identifiers	Sugiyama3 MPD:125
Data changelog	No updates/corrections. Initial release date: 01/2008.

To identify genomic regions that regulate systolic blood pressure, heart rate, and heart weight, F2 progeny were generated from an intercross involving BALB/cJ and CBA/CaJ. Mice were trained on Days 1-5 on the apparatus, and testing was conducted over Days 8-10. Tests generated 20 measurements per day. The mean for the testing period is reported for blood pressure and heart rate. Body and heart weights were determined after testing. See Sugiyama et al, 2002 for detailed protocols.

QTL data set parameters:

Progenitor strains	BALB/cJ CBA/CaJ
Cross type	F2 intercross
Population size	0 ♀ 208 ♂
Age	10wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Sugiyama3	tail cuff	(none)	systolic blood pressure, training day 1 [mmHg] BP_d1 12502	QTL population	m	10wks	N=208

Sugiyama3	tail cuff	(none)	systolic blood pressure, training day 2 [mmHg] BP_d2 12503	QTL population	m	10wks	N=208

Sugiyama3	tail cuff	(none)	systolic blood pressure, training day 3 [mmHg] BP_d3 12504	QTL population	m	10wks	N=208

Sugiyama3	tail cuff	(none)	systolic blood pressure, training day 4 [mmHg] BP_d4 12505	QTL population	m	10wks	N=208

Sugiyama3	tail cuff	(none)	systolic blood pressure, training day 5 [mmHg] BP_d5 12506	QTL population	m	10wks	N=208

Sugiyama3	tail cuff	(none)	systolic blood pressure, mean for testing days 8-12 [mmHg] BP_final 12507	QTL population	m	10wks	N=208

Sugiyama3	tail cuff	(none)	heart rate, beats per minute, mean for testing days 8-12 [n/min] HR_final 12508	QTL population	m	10wks	N=208

Sugiyama3	body weight	(none)	body weight after testing [g] bw 12509	QTL population	m	10wks	N=208

Sugiyama3	body weight	(none)	body weight after testing, log transformed [log(g)] bw_log 12510	QTL population	m	10wks	N=208

Sugiyama3	organ weights	(none)	heart weight after testing [mg] heart_wt 12511	QTL population	m	10wks	N=208

Sugiyama3	organ weights	(none)	heart weight after testing, log transformed [log(mg)] heart_wt_log 12512	QTL population	m	10wks	N=208

To see more rows use the paging control at top.

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Bpq31 Bpq7 Hrq1 Hrq2 Hrq3 Hwq1

Project / data set: Sugiyama3 a.k.a. Sugiyama_2002
Excel file: Data_Description_BALBxCBA_Sugiyama2002.xlsx
CSV file: Sugiyama2002_BALBxCBA_B37_Data.csv
Readme / text file: readme_Sugiyama2002.txt