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Investigators	Gillian Beamer       Texas Biomedical Research Institute,  San Antonio, TX Daniel M Gatti       The Jackson Laboratory,  Bar Harbor, ME
Contact	Gillian Beamer     GBeamer@txbiomed.org
Affiliated Center	Tufts University
Project type	Phenotype strain survey data set
MPD identifiers	Project1132     MPD:1132
Data changelog	This project has not yet been released.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

The number of humans who develop tuberculosis (TB) due to Mycobacterium tuberculosis is staggering: Each year, 8-9 million new cases are diagnosed, and 1-2 million patients die of TB. Fundamental research questions remain unanswered, including how host genetics contributes to susceptibility. Here, we address the genetic basis of TB using the Diversity Outbred (DO) mouse population to model human genotypic and phenotypic heterogeneity. We also infect with a realistic, low dose of aerosolized, virulent M. tuberculosis bacilli to recapitulate the natural exposure route and infectious dose for humans. Following infection with M. tuberculosis, DO mice show highly variable responses to M. tuberculosis, that are not observed in inbred mouse strain

Experimental groups in this study:
• 0 CFU M.tb     • 14 CFU M.tb     • 15 CFU M.tb     • 16 CFU M.tb     • 20 CFU M.tb     • 28 CFU M.tb     • 34 CFU M.tb     • 86 CFU M.tb     • 127 CFU M.tb