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Project1061: Nicotine withdrawal deficits in BXD strains (2021) [Pending]

Goldberg LR, Kutlu MG, Zeid D, Seemiller LR, Gould TJ. Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning. Genes Brain Behav. doi: 10.1111/gbb.12734.   PubMed 33797169  


         
Project1061 downloads
• Download Project1061 project data set     animal data, as uploaded
• Download Project1061 animal data matrix     with factor-related expansion applied as necessary
• Download Project1061 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Thomas J Gould       Pennsylvania State University,  University Park, PA
Lisa Goldberg       Pennsylvania State University,  University Park, PA
ContactThomas J Gould
Funding Provided ByNational Institute of General Medical Sciences, Grant/Award Number: T32GM108563; National Institute on Drug Abuse, Grant/Award Number: 1U01DA041632; Pennsylvania State University, Grant/Award Number: Jean Phillips Shibley Endowment
Project type Phenotype strain survey data set
MPD identifiersProject1061     MPD:1061
Data changelog This project has not yet been released.
Formatted citation
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[No procedure abstracts have been defined yet]
Cognitive deficits, such as disrupted learning, are a major symptom of nicotine withdrawal. These deficits are heritable, yet their genetic basis is largely unknown. Our lab has developed a mouse model of nicotine withdrawal deficits in learning, using chronic nicotine exposure via osmotic minipumps and fear conditioning. Here, we utilized the BXD genetic reference panel to identify genetic variants underlying nicotine withdrawal deficits in learning. Male and female mice (n = 6-11 per sex per strain, 31 strains) received either chronic saline or nicotine (6.3 mg/kg per day for 12 days), and were then tested for hippocampus-dependent learning deficits using contextual fear conditioning.

Experimental groups in this study:
• saline     • nicotine    

Mice: BXD w/par   31 strains   ♀♂   age 6-20 wks   2 experimental groups