MPD: Data set: Pitman1

Pitman1: Plasma HDL cholesterol regulation in backcross progeny involving NZB/BlNJ and SM/J (2002)

Pitman WA, Korstanje R, Churchill GA, Nicodeme E, Albers JJ, Cheung MC, Staton MA, Sampson SS, Harris S, Paigen B. Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice. Physiol Genomics. 2002;9(2):93-102. PubMed 12006675

A backcross involving NZB/BlNJ and SM/J inbred mouse strains was generated to identify QTLs involved in plasma HDL cholesterol concentrations. Blood lipids were measured in backcross progeny administered a high-fat (15%) diet at 6-8 wks of age. The diet was maintained for 18 wks; mice were tested at regular intervals. Plasma was obtained from fasted mice (4 hr). For detailed protocols see Pitman et al 2002.

Note on studied population: NZB/BlNJ x SM/J backcross progeny

Procedures conducted:

• study archive

Cholesterol (plasma) after high-fat diet (several timepoints).

Pitman1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Pitman1 measures:

Investigators	W A Pitman Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Korstanje R, Nicodeme E, Albers JJ, Cheung MC, Staton MA, Sampson SS, Harris S, Paigen B
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Funding provided by NIH HL32087, HL30086, CA34196; and GlaxoWellcome
Project type	QTL Archive data set
MPD identifiers	Pitman1 MPD:123
Data changelog	No updates/corrections. Initial release date: 01/2008.

QTL data set parameters:

Progenitor strains	NZB/BlNJ SM/J
Cross direction notation	(SM x NZB) x NZB
Cross type	Backcross
Population size	89 ♀ 0 ♂

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Pitman1	lipid profile	(none)	HDL cholesterol (plasma), chow [mg/dL] HDL_chow 12301	QTL population	f	6-8wks	N=89

Pitman1	lipid profile	high-fat diet	HDL cholesterol (plasma), high-fat diet 4 wks [mg/dL] HDL_fat4 12302	QTL population	f	10-12wks	N=89

Pitman1	lipid profile	high-fat diet	HDL cholesterol (plasma), high-fat diet 8 wks [mg/dL] HDL_fat8 12303	QTL population	f	14-16wks	N=89

Pitman1	lipid profile	high-fat diet	HDL cholesterol (plasma), high-fat diet 18 wks [mg/dL] HDL_fat18 12304	QTL population	f	24-26wks	N=89

Pitman1	lipid profile	(none)	total cholesterol (plasma), chow [mg/dL] chol_chow 12305	QTL population	f	6-8wks	N=89

Pitman1	lipid profile	high-fat diet	total cholesterol (plasma), high-fat diet 4 wks [mg/dL] chol_fat4 12306	QTL population	f	10-12wks	N=89

Pitman1	lipid profile	high-fat diet	total cholesterol (plasma), high-fat diet 8 wks [mg/dL] chol_fat8 12307	QTL population	f	14-16wks	N=89

Pitman1	lipid profile	high-fat diet	total cholesterol (plasma), high-fat diet 18 wks [mg/dL] chol_fat18 12308	QTL population	f	24-26wks	N=89

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Hdlq2 Hdlq3 Hdlq4

Project / data set: Pitman1 a.k.a. Pitman_2002
Excel file: Data_Description_SMxNZB_Pitman2002.xlsx
CSV file: Pitman2002_SMxNZB_B37_Data.csv
Readme / text file: readme_Pitman2002.txt
QC plots, figures, etc.: QCReport_Pitman2002.pdf