Petryshen1: Prepulse inhibition in C57BL/6J-Chr#A/J/NaJ mouse chromosome substitution panel (males) (2009)

Leussis MP, Frayne ML, Saito M, Berry EM, Aldinger KA, Rockwell GN, Hammer RP Jr, Baskin-Hill AE, Singer JB, Nadeau JH, Sklar P, Petryshen TL. Genomic survey of prepulse inhibition in mouse chromosome substitution strains. Genes Brain Behav. 2009 Nov;8(8):806-16. Epub 2009 Jul 21.   PubMed 19694817  


           
Notes
[MPD curation comment]: Since acoustic startle response is highly dependant on hearing ability, it is noteworthy that C57BL/6J strain is homozygous for Cdh23ahl (cadherin 23, otocadherin) on mouse chromosome 10. The age related hearing loss 1 (ahl) mutation, on this background results in progressive hearing loss with onset after 10 mo of age. Additionally, A/J is also homozygous for Cdh23ahl which on A/J background results in progressive hearing loss with onset between 3 and 5 mo of age. While it is possible that mice from the B6.A-Chr10 strain have the least ASR performance due to one of these hearing loss loci, mice were tested prior to the known onset of hearing loss for these loci.

Petryshen1 downloads
• Download Petryshen1 project data set     animal data, as uploaded
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• Download Petryshen1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Tracey L Petryshen       Harvard Medical School,  Boston, MA
Melanie P Leussis       Harvard Medical School,  Boston, MA
Participants Frayne ML, Saito M, Berry EM, Aldinger KA, Rockwell GN, Hammer RP Jr, Baskin-Hill AE, Singer JB, Nadeau JH, Sklar P
ContactTracey L Petryshen     petryshen@chgr.mgh.harvard.edu     Lab web site
AcknowledgementsFunding provided by NIH MH071673, RR12305, MH0703930; Stanley Medical Research Institute, National Alliance for Research on Schizophrenia and Depression, Canadian Institutes of Health of Research
Project type Phenotype strain survey data set
MPD identifiersPetryshen1     MPD:347
Data changelog 1 update/correction.       Initial release date: 10/2010.
Formatted citation
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An investigation of QTLs for prepulse inhibition and acoustic startle response. Acoustic startle was measured for various stimuli: a 120 dB pulse alone, or a pulse preceded by different prepulse intensities (70, 75, 80, 85 dB). Prepulse inhibition was calculated from the pulse alone and prepulse-pulse startle data. Animals were evaluated using the Kinder Scientific startle reflex measurement system.

Procedures conducted:
• acoustic startle test  Acoustic startle response, prepulse inhibition.

Mice: B6.A consomic   22 strains   ♂   age 7-9wks   1 experimental group