MPD: Data set: Mrug1

Mrug1: Identification of polycystic kidney disease modifier candidate in cpk mutant mice (2005)

Mrug M, Li R, Cui X, Schoeb TR, Churchill GA, Guay-Woodford LM. Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse. J Am Soc Nephrol. 2005 Apr;16(4):905-16. Epub 2005 Feb 23. PubMed 15728779

Mrug1 downloads
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Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Mrug1 measures:

MA:0000358 liver
MA:0000368 kidney
MP:0001259 abnormal body weight
MP:0001845 abnormal inflammatory response
MP:0002135 abnormal kidney morphology
MP:0002706 abnormal kidney size
MP:0002707 abnormal kidney weight
MP:0009494 abnormal biliary ductule morphology
VT:0001259 body mass
VT:0002706 kidney size trait
VT:0002707 kidney mass
VT:0005083 biliary tract morphology trait
VT:0010139 immune response trait

Investigators	M Mrug Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Li R, Cui X, Schoeb TR, Guay-Woodford LM
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	This work was supported by a Polycystic Kidney Disease Foundation Fellowship Award (M.M.), a Clinical Scientist Award in Translational Research from the Burroughs-Wellcome Foundation (L.M.G.-W.), and the National Institutes of Health (G.A.C.).
Project type	QTL Archive data set
MPD identifiers	Mrug1 MPD:175
Data changelog	No updates/corrections. Initial release date: 08/2011.

The cpk mutant mouse is the most characterized model of autosomal recessive polycystic kidney disease. To identify the modifier that modulates disease severity, an intercross between B6-+/cpk (heterozygous for the Cys1^cpk mutation) and CAST was generated and 461 F2 cpk homozygous mice were examined for renal phenotypes. A major contributed QTL is mapped on chromosome 4 and gene Kif12 is found in this region. This gene is proposed as a cpk modifier gene of renal disease. For detailed protocols see Mrug et al 2005.

QTL data set parameters:

Progenitor strains	C57BL/6J-+/cpk CAST/EiJ
Cross type	F2 intercross
Population size	209 ♀ 251 ♂
Notes	the sex information of 1 mouse is missing

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Mrug1	histopathology	(none)	mean of biliary duct number [n] mean_BDN 17501	QTL population	both	10d	N=230

Mrug1	histopathology	(none)	mean of log(biliary duct number) [log(n)] mean_logBDN 17502	QTL population	both	1wk	N=230

Mrug1	histopathology	(none)	cholangitis severity (score 0-4, increasing severity) 0 = no/minimal inflammation, 4=severe and extensive cholangiohepatitis [score] Cholangitis 17503	QTL population	both	10d	N=230

Mrug1	organ dimensions	(none)	kidney length [mm] Klength 17504	QTL population	both	10d	N=230

Mrug1	organ dimensions	(none)	kidney length, square root [sqrt(mm)] sqrtKL 17505	QTL population	both	10d	N=230

Mrug1	organ dimensions	(none)	crown to rump length of kidney [mm] CRLength 17506	QTL population	both	10d	N=230

Mrug1	organ dimensions	(none)	kidney weight/crown to rump length KL-CRL-Ratio 17507	QTL population	both	10d	N=230

Mrug1	organ dimensions	(none)	kidney weight/crown to rump length, log transformed logKL-CRL-Ratio 17508	QTL population	both	10d	N=230

Mrug1	organ weights	(none)	kidney weight [g] KW 17509	QTL population	both	10d	N=230

Mrug1	organ weights	(none)	kidney weight, square root [sqrt(g)] sqrtKW 17510	QTL population	both	10d	N=230

Mrug1	body weight	(none)	mouse body weight [g] BodyWeight 17511	QTL population	both	10d	N=230

Mrug1	organ weights	(none)	kidney weight/body weight KW-BW-Ratio 17512	QTL population	both	10d	N=230

Mrug1	organ weights	(none)	kidney weight/body weight, log transformed logKW-BW-ratio 17513	QTL population	both	10d	N=230

Mrug1	organ dimensions	(none)	kidney volume [ml] KVolume 17514	QTL population	both	10d	N=230

Mrug1	organ dimensions	(none)	kidney volume, square root [sqrt(ml)] sqrtKV 17515	QTL population	both	10d	N=230

Mrug1	organ dimensions	(none)	renal principal component of kidney length, weight and volume Prin1 17516	QTL population	both	10d	N=230

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Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Mpdk1 Mpdk2 Mpdk3 Mpdk4 Mpdk5 Mpdk6 Mpdk7 Mpdk8

Project / data set: Mrug1 a.k.a. Mrug_2005
Excel file: Data_Description_B6xCAST_Mrug2005.xlsx
CSV file: Mrug2005_B6xCAST_B37_Data.csv
Readme / text file: readme_Mrug2005.txt
QC plots, figures, etc.: QCReport_Mrug2005.pdf